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The Acute Effect of Different Resistance Exercise Loads on Irisin and Brain-derived Neurotrophic Factor in Blood Serum and Plasma

NCT ID: NCT07189130

Last Updated: 2025-12-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-05-12

Study Completion Date

2026-09-30

Brief Summary

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The aim of this study is to investigate different resistance training loads on BNDF and irisin levels in platelets, blood serum and plasma.

Detailed Description

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In this study, the investigators will examine how three resistance training protocols acutely affect BDNF levels (in serum, plasma, platelet count, and BDNF per platelet) and irisin levels in blood (plasma). The resistance training protocols will differ in intensity, rest intervals between sets and repetition execution. Blood samples will be collected from participants at four time points: before the start of the protocol, 5 minutes after completion of the final set, 1 hour after completion of the final set, and 3 hours after completion of the final set. In addition, blood lactate levels will be monitored at the same time points. Heart rate will also be recorded (immediately before the start of the protocol and 30 seconds after completion of the final set). A control protocol will also be implemented, in which blood will be collected at the same time points. Data will be collected across five visits to the kinesiology laboratory at the University of Ljubljana, Faculty of Sport. Each visit will last approximately 4 hours, except for the first visit where 1RM will be measured.

Conditions

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BDNF Irisin Resistance Exercise Stroop Test Lactate Healthy Young Adult

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Intervention: participants going through exercising or control

All participants will do 1 control protocol and 3 resistance exercises protocols. Order of protocols will be randomized.

Group Type EXPERIMENTAL

Exercise: 80% 1 RM with 2 minutes break

Intervention Type OTHER

Participant will do resistance exercise at 80% 1RM with 2 minutes break, 4 sets of each exercise. Included exercises are lat pull, bench press and leg press.

Exercise: 80% 1RM with1 minute break

Intervention Type OTHER

Participant will do resistance exercise at 80% 1RM with 1 minutes break, 4 sets of each exercise. Included exercises are lat pull, bench press and leg press.

Exercise: accenuated eccentric exercise

Intervention Type OTHER

Participant will do accenuated eccentric resistance exercise at 80% 1RM in concetric part of movement and 110% 1RM in eccentric part of movement with 2 minutes break, 4 sets of each exercise. Included exercises are lat pull, bench press and leg press.

Control

Intervention Type OTHER

Timeline of events will be same as in exercise protocol (blood withdrawal and Stroop test), except participants will not do any kind of exercise protocol, instead they will be seating.

Interventions

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Exercise: 80% 1 RM with 2 minutes break

Participant will do resistance exercise at 80% 1RM with 2 minutes break, 4 sets of each exercise. Included exercises are lat pull, bench press and leg press.

Intervention Type OTHER

Exercise: 80% 1RM with1 minute break

Participant will do resistance exercise at 80% 1RM with 1 minutes break, 4 sets of each exercise. Included exercises are lat pull, bench press and leg press.

Intervention Type OTHER

Exercise: accenuated eccentric exercise

Participant will do accenuated eccentric resistance exercise at 80% 1RM in concetric part of movement and 110% 1RM in eccentric part of movement with 2 minutes break, 4 sets of each exercise. Included exercises are lat pull, bench press and leg press.

Intervention Type OTHER

Control

Timeline of events will be same as in exercise protocol (blood withdrawal and Stroop test), except participants will not do any kind of exercise protocol, instead they will be seating.

Intervention Type OTHER

Other Intervention Names

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resistance exercise resistance exercise

Eligibility Criteria

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Inclusion Criteria

* males between 18 and 30 years
* moderate level of physical activity assessed with IPAQ

Exclusion Criteria

* injuries
* cardiovascular diseases
* respiratory diseases
* psychiatric diseases
* metabolic diseases
* other neurodegenerative diseases
Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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University of Ljubljana

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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University of Ljubljana, Faculty of Sport

Ljubljana, , Slovenia

Site Status

Countries

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Slovenia

Other Identifiers

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0120-222/2024-2711-3

Identifier Type: -

Identifier Source: org_study_id