Evolving Diagnostic Approaches to Undocumented Lymphocytic Meningitis and Meningoencephalitis
NCT ID: NCT07186881
Last Updated: 2025-09-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ENROLLING_BY_INVITATION
200 participants
OBSERVATIONAL
2022-08-15
2026-08-15
Brief Summary
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Detailed Description
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According to initial data collected by Santé publique France, eastern France is the most affected region, with over half of the reported cases occurring in the Rhône-Alpes and Alsace regions. However, this infection remains relatively unfamiliar to many clinicians and is infrequently investigated during routine diagnostic procedures.
Across France, numerous cases of lymphocytic meningitis remain without a definitive diagnosis, notably at the Nancy University Hospital, where approximately 150 such cases are recorded annually. It is plausible that a proportion of these cases are secondary to TBE infection.
The hypothesis underlying this study is based on these observations. Diagnostic practices at the Nancy University Hospital are currently evolving. The infectious diseases team is actively working to increase clinicians' awareness of TBE, encouraging them to consider this diagnosis when presented with compatible clinical scenarios. Specifically, in cases suggestive of TBE, the infectious diseases team now routinely recommends testing for this pathogen.
This change in practice may lead to an increased rate of documented TBE cases and potentially improve patient management.
The primary objective of this study is to assess the impact of this change in diagnostic practice on the work-up of undocumented lymphocytic meningitis and meningoencephalitis at Nancy University Hospital.
Conditions
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Study Design
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OTHER
RETROSPECTIVE
Study Groups
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Period before the change of practice
We are examining a change in clinical practice within our institution. Prior to this change, testing for tick-borne encephalitis (TBE) was not routinely performed in cases of meningitis and meningoencephalitis. Following the implementation of the new protocol, our infectious diseases team now recommends that all clinicians managing patients with compatible clinical presentations conduct TBE serology.
The patient cohort described here corresponds to the period preceding this change in practice.
No interventions assigned to this group
Period after the change of practice
We are examining a change in clinical practice within our institution. Prior to this change, testing for tick-borne encephalitis (TBE) was not routinely performed in cases of meningitis and meningoencephalitis. Following the implementation of the new protocol, our infectious diseases team now recommends that all clinicians managing patients with compatible clinical presentations conduct TBE serology.
The patient cohort described here corresponds to the period following this change in practice.
Recommendation from the infectious diseases team
No commercial product was evaluated in this study. We are assessing the benefits and consequences of a change in clinical practice implemented at the hospital level. At our institution, it is now recommended that TBE serology be performed in all cases of undocumented meningitis or meningoencephalitis.
The infectious diseases team at our hospital simply advises the clinicians responsible for patient care to perform this test.
Interventions
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Recommendation from the infectious diseases team
No commercial product was evaluated in this study. We are assessing the benefits and consequences of a change in clinical practice implemented at the hospital level. At our institution, it is now recommended that TBE serology be performed in all cases of undocumented meningitis or meningoencephalitis.
The infectious diseases team at our hospital simply advises the clinicians responsible for patient care to perform this test.
Eligibility Criteria
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Inclusion Criteria
* Adults or children
* Hospitalised in a department of Nancy University Hospital with a diagnosis of lymphocytic meningitis or meningoencephalitis
* Cerebrospinal fluid showing more than 5 cells/mm³, with either a negative FilmArray result or no FilmArray performed
Exclusion Criteria
* Patients with documented lymphocytic meningitis or meningoencephalitis of a known cause (excluding TBE) prior to the date the advisory was issued
* Patients who have expressed opposition to the use of their data for this study
ALL
No
Sponsors
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Central Hospital, Nancy, France
OTHER
Responsible Party
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LEFEVRE Benjamin
Doctor (MD PhD)
Locations
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University Hospital of Nancy, Brabois Hospital
Vandœuvre-lès-Nancy, Lorraine, France
Countries
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Other Identifiers
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CHAN-MEE
Identifier Type: -
Identifier Source: org_study_id
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