Perioperative Outcomes and Survival of Inflatable Video-Assisted Mediastinoscopic Transhiatal Esophagectomy for Selected Esophageal Cancer

NCT ID: NCT07182266

Last Updated: 2025-09-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1661 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-01-04

Study Completion Date

2025-09-01

Brief Summary

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Perioperative and oncologic benefits of inflatable video-assisted mediastinoscopic transhiatal esophagectomy (IVMTE) are unclear. This retrospective study aimed to compare the differences in perioperative outcomes and survival between IVMTE and video-assisted McKeown esophagectomy (VME).

Detailed Description

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Conditions

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Esophageal Carcinoma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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IVMTE

The patient was positioned supine. A 5-cm cervical incision was made along the anterior border of the left sternocleidomastoid muscle as the main surgical route. The skin and subcutaneous tissues were carefully incised in layers. The left recurrent laryngeal nerve (RLN) was identified and traced, followed by mobilization of the cervical esophagus. A lap protector was inserted into the left incision to create a closed cavity, and the mediastinum was insufflated with carbon dioxide at 8 mmHg. Three 5-mm trocars were used for the specialized retractor, LigaSure Maryland jaw sealer, and mediastinoscope. Then, the esophagus was dissected up to the level of the carina or the inferior pulmonary vein. During this process, mediastinal lymph nodes were also removed, including bilateral RLN, paraesophageal, tracheobronchial, and subcarinal nodes. If necessary, the incision was then extended to the right neck to facilitate the dissection of the right cervical lymph nodes.

No interventions assigned to this group

VME

traditional video-assisted McKeown esophagectomy

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

(I) primary esophageal cancer confirmed by endoscopic biopsy and (II) diagnosed resectable tumors based on positron emission tomography-computed tomography (PET-CT) according to the International Union Against Cancer Tumor, Node, Metastasis (TNM) Classification (8th edition)

Exclusion Criteria

(I) presence of other advanced malignancies, (II) insufficient clinical data, or (III) postoperative follow-up of less than 12 months.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Shanghai Zhongshan Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Zhongshan Hospital, Fudan University

Shanghai, Shanghai Municipality, China

Site Status

Countries

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China

Other Identifiers

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20ZR1411600

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

SHDC2020CR4039

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

B2024-122R

Identifier Type: -

Identifier Source: org_study_id

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