Ketamine in Central Sensitization

NCT ID: NCT07182032

Last Updated: 2025-11-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

PHASE4

Total Enrollment

126 participants

Study Classification

INTERVENTIONAL

Study Start Date

2026-02-01

Study Completion Date

2028-06-30

Brief Summary

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The purpose of this research study is to see if ketamine infusion during surgery can decrease pain after surgery. Ketamine is a medication commonly used as part of anesthesia during surgery and is approved by the US FDA.

Patients will be randomized to either receive standard anesthesia with OR without ketamine. The surgical procedure will be the same regardless of which group patients are randomized to. After surgery, patients will be asked to rate their pain in the post-operative observation unit and at their two-week post-operative visit. No additional visits are required for participation in this study. The investigators estimate the surveys will take approximately 10 minutes to complete.

Detailed Description

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Conditions

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Endometriosis Chronic Pelvic Pain

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Control

standard general anesthesia without ketamine

Group Type NO_INTERVENTION

No interventions assigned to this group

Ketamine

standard general anesthesia with ketamine

Group Type EXPERIMENTAL

ketamine

Intervention Type DRUG

Participants will receive general anesthesia with protocoled ketamine infusion

Interventions

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ketamine

Participants will receive general anesthesia with protocoled ketamine infusion

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* age range 18-89
* ASA classification I-III
* outpatient elective laparoscopy for endometriosis

Exclusion Criteria

* known allergy or contraindication to ketamine
* History of substance use disorder, including alcohol or marijuana use, both current and remote
* History of severe psychiatric illness, including schizoaffective disorder, bipolar disorder, psychosis, or decompensated psychiatric condition , excluding anxiety and depression
* Current Intraoperative complications
Minimum Eligible Age

18 Years

Maximum Eligible Age

89 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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University Hospitals Cleveland Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Adi Cosic

Physician

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Adi Cosic, DO

Role: PRINCIPAL_INVESTIGATOR

University Hospitals

Morgan Cheeks, MD

Role: PRINCIPAL_INVESTIGATOR

University Hosptials

Locations

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University Hospitals Cleveland Medical Center

Cleveland, Ohio, United States

Site Status

Countries

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United States

Central Contacts

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Adi Cosic, MD

Role: CONTACT

216-844-2273

Facility Contacts

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Adi Cosic, DO

Role: primary

216-844-2273

Other Identifiers

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STUDY20250700

Identifier Type: -

Identifier Source: org_study_id

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