Association of Biomarkers and Gastric Antral Motility Index With Feeding Intolerance in Critically Ill Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Total Enrollment

160 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-10-20

Study Completion Date

2026-12-31

Brief Summary

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When the subjects are admitted to the department, the researchers will monitor potential biomarkers of gastrointestinal injury before administering enteral nutrition (a small amount of blood is drawn, serum is separated by centrifugation, and the serum sample is frozen for final centralized biomarker detection), and measure the antral movement index under ultrasound (300ml of warm water is injected into the stomach before measurement, and then the antral movement is observed for 6 minutes) Then, monitor whether the patient has developed feeding intolerance within 7 days of the ICU

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Detailed Description

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Conditions

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Critically Ill Patients Who Are Not Allowed to Eat Orally But Can Initiate Enteral Nutrition Within 48 Hours of ICU

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Critically ill patients who initiated enteral nutrition early

Not applicable- observational study

Intervention Type OTHER

This is a prospective observational study and does not involve any intervention measures

Interventions

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Not applicable- observational study

This is a prospective observational study and does not involve any intervention measures

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age ≥18 years
* Presence of one or more organ system failures within 24 hours of ICU admission (SOFA score ≥2)
* Expected ICU stay \>48 hours
* Inability to take oral nutrition
* No contraindications to enteral nutrition (EN)

Exclusion Criteria

* Patients who have already received enteral nutrition prior to gastric antral motility measurement or biomarker collection
* Receiving palliative care with expected death within 48 hours
* Pregnancy
* Participation in another clinical trial

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No