Oct-A and Perimetry in Multiple Sclerosis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

32 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-09-30

Study Completion Date

2026-10-31

Brief Summary

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This study aims to assess retinal vascular density using OCT-A and correlate these parameters with visual field changes in MS patients with and without a history of ON

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Detailed Description

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The aim of this work is to investigate the correlation between visual field parameters and optical coherence tomography angiography (OCT-A) findings in patients with multiple sclerosis (MS). MS is a chronic autoimmune demyelinating disease that frequently involves the visual pathway, often presenting with optic neuritis (ON) and subsequent neurodegeneration. OCT-A, a non-invasive imaging modality, enables detailed visualization and quantification of retinal microvasculature, particularly the superficial and deep capillary plexuses, which supply the retinal ganglion cells and nerve fiber layers. Previous studies have demonstrated reduced retinal vessel density and thinning of retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) in MS patients, reflecting neuro-axonal damage and microvascular impairment. However, the relationship between these structural and vascular changes and functional visual outcomes, such as visual field loss, remains to be fully elucidated.

This study aims to assess retinal vascular density using OCT-A and correlate these parameters with visual field indices in MS patients with and without a history of ON. By analyzing inter-eye differences and comparing with MS patients, the research seeks to clarify whether OCT-A metrics can serve as reliable biomarkers for visual dysfunction and disease progression in MS. Understanding this correlation could improve early detection of neuroretinal damage, guide monitoring of disease activity, and potentially inform therapeutic strategies.

Conditions

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Multiple Sclerosis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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patients with multiple sclerosis

optical coherence tomography angiography

Intervention Type DEVICE

correlation between OctA and Visual field changes in Multiple Sclerosis

Visual Field Perimetry

Intervention Type DEVICE

Correlation between OctA and Visual field changes in Multiple sclerosis

healthy control

optical coherence tomography angiography

Intervention Type DEVICE

correlation between OctA and Visual field changes in Multiple Sclerosis

Visual Field Perimetry

Intervention Type DEVICE

Correlation between OctA and Visual field changes in Multiple sclerosis

Interventions

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optical coherence tomography angiography

correlation between OctA and Visual field changes in Multiple Sclerosis

Intervention Type DEVICE

Visual Field Perimetry

Correlation between OctA and Visual field changes in Multiple sclerosis

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of relapsing-remitting multiple sclerosis (RR-MS) or other MS subtypes confirmed by established neurological criteria. .Ability to undergo OCTA imaging and visual field testing. .Visual acuity sufficient to perform reliable visual field testing.
* Absence of other ocular diseases affecting the retina or optic nerve (e.g., diabetic retinopathy, glaucoma)

Exclusion Criteria

.History of ocular diseases unrelated to MS that could confound OCTA or visual field results.

.Recent optic neuritis episode within a defined period (often 3-6 months) to avoid acute inflammation effects.

.Media opacities preventing quality OCTA imaging. .Systemic diseases that may affect retinal vasculature (e.g., uncontrolled hypertension, diabetes).

.Poor cooperation or inability to complete visual field testing reliably

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes