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Educational Tools for the Improvement of Early Advance Care Planning in Adolescents and Young Adults With Advanced Solid Tumors and High-Grade Brain Tumors

NCT ID: NCT07174661

Last Updated: 2025-12-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-09-02

Study Completion Date

2027-06-30

Brief Summary

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This clinical trial studies whether educational tools work to improve early advance care planning (ACP) in adolescents and young adults (AYAs) with solid tumors that may have spread from where they first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) and high-grade brain tumors. The incidence of AYA cancers is on the rise with approximately 90,000 new diagnoses yearly in the United States. Cancer remains the leading cause of disease-related death among AYAs, which could be due to patients having more advanced disease at presentation. It is recommended that AYAs begin ACP conversations at the start of treatment. ACP includes clarifying goals of care, discussions about end-of-life preferences, and completing a legal document that states the treatment or care a person wishes to receive or not receive if they become unable to make medical decisions (advance directive). The educational tools in this study include an early ACP educational video featuring AYAs with cancer and an ACP appointment geared for AYAs. Patients can access and watch the educational video at home prior to their scheduled ACP appointment. During the ACP appointment, a tailored ACP guide made specifically for AYAs is reviewed and questions regarding ACP are answered. This may help to introduce the importance of key ACP concepts, which may improve early ACP in AYAs with advanced solid tumors and high-grade brain tumors.

Detailed Description

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Conditions

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Advanced Malignant Solid Neoplasm Malignant Brain Neoplasm Recurrent Advanced Malignant Solid Neoplasm

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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Supportive care (early ACP)

Patients watch a brief, on-demand early ACP educational video at baseline and then one month later attend an ACP appointment with either an AYA social worker or AYA palliative medicine physician assistant over 1 hour.

Group Type EXPERIMENTAL

Advance Care Planning

Intervention Type BEHAVIORAL

Attend ACP appointment

Educational Intervention

Intervention Type OTHER

Watch on-demand early ACP educational video

Electronic Health Record Review

Intervention Type OTHER

Ancillary studies

Survey Administration

Intervention Type OTHER

Ancillary studies

Interventions

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Advance Care Planning

Attend ACP appointment

Intervention Type BEHAVIORAL

Educational Intervention

Watch on-demand early ACP educational video

Intervention Type OTHER

Electronic Health Record Review

Ancillary studies

Intervention Type OTHER

Survey Administration

Ancillary studies

Intervention Type OTHER

Other Intervention Names

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Education for Intervention Intervention by Education Intervention through Education Intervention, Educational

Eligibility Criteria

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Inclusion Criteria

* Age 18-39 at initial cancer diagnosis

* Patient \<18 years of age are not included in this pilot as Mayo Clinic in Arizona (MCA) does not treat pediatric patients
* Recently diagnosed (defined as 12 months or less from initial diagnosis or advance stage relapse) with either a stage III/IV solid malignancy or high-grade brain tumor. This includes patients who have stage III/IV recurrence of previously stage I/II solid malignancy
* Actively receiving primary oncologic care at Mayo Clinic Arizona
* Able to read, understand, and speak English
* Those who have completed prior advance directive documents are still eligible to participate.

Exclusion Criteria

* Age \< 18 or \> 39 at initial cancer diagnosis
* Diagnosed with stage I/II solid malignancy, low-grade brain tumor, or hematologic malignancy
* Not receiving primary oncologic care at Mayo Clinic Arizona
* Unable to read, understand, and speak English
* Patients \> 12 months from initial diagnosis or advanced stage relapses, in survivorship or on hospice
* No internet or computer/smart phone access
Minimum Eligible Age

18 Years

Maximum Eligible Age

39 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Mayo Clinic

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Allison C. Rosenthal, DO

Role: PRINCIPAL_INVESTIGATOR

Mayo Clinic

Locations

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Mayo Clinic in Arizona

Scottsdale, Arizona, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Sey Oloyede

Role: CONTACT

Phone: 507-538-6811

Email: [email protected]

Clinical Trials Referral Office

Role: CONTACT

Phone: 855-776-0015

Email: [email protected]

Facility Contacts

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Sey Oloyede

Role: primary

Clinical Trials Referral Office

Role: backup

Related Links

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https://www.mayo.edu/research/clinical-trials

Mayo Clinic Clinical Trials

Other Identifiers

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NCI-2025-06307

Identifier Type: REGISTRY

Identifier Source: secondary_id

25-007280

Identifier Type: OTHER

Identifier Source: secondary_id

25-007280

Identifier Type: -

Identifier Source: org_study_id