The Effect of Video Game-Based Exercise Training in Patients With Interstitial Lung Disease
NCT ID: NCT07167238
Last Updated: 2025-12-17
Study Results
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Basic Information
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NOT_YET_RECRUITING
NA
42 participants
INTERVENTIONAL
2026-01-25
2026-11-25
Brief Summary
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The main questions it aims to answer are:
Does video game-based rehabilitation improve respiratory function parameters in individuals with ILD?
Does video game-based rehabilitation reduce dyspnea and exercise intolerance, thereby improving functional exercise capacity?
Does video game-based rehabilitation increase participation and completion rates in pulmonary rehabilitation programs? Study Design: A total of 42 participants diagnosed with mild-to-moderate ILD will be recruited. Participants will be randomized into two groups (21 in the intervention group, 21 in the control group) using stratified randomization to ensure homogeneity by age, sex, and ILD type.
Arms: 2 (Intervention group and Control group)
Intervention:
Intervention group: Structured video game-based exercise training sessions as part of a pulmonary rehabilitation program.
Control group: Conventional pulmonary rehabilitation program.
Assessments: Respiratory function, functional exercise capacity, and symptom levels will be measured before and after the intervention.
Inclusion criteria:
Diagnosis of mild-to-moderate ILD
Aged 20-70 years
Referral by a treating physician
Willingness and ability to participate
No physical or cognitive barriers to exercise training
Exclusion criteria:
Cardiovascular disease (e.g., acute heart failure, unstable angina, recent myocardial infarction)
Cognitive impairment
History of cerebrovascular event
History of cancer
Withdrawal criteria:
Development of clinical hemodynamic instability
Major surgical complication during the study
Missing ≥ 3 consecutive training sessions in the intervention group
Withdrawal of consent
Detailed Description
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Technology-assisted rehabilitation, particularly video game-based training (exergaming), has emerged as a promising strategy to enhance motivation and adherence while preserving the physiological benefits of exercise. Exergaming provides real-time feedback, goal-oriented tasks, and progressive challenges that may improve enjoyment, engagement, and consistency of participation. In respiratory rehabilitation, game-guided breathing exercises may reinforce techniques such as pursed-lip breathing, diaphragmatic breathing, and thoracic expansion, which optimize ventilatory mechanics and potentially reduce dyspnea. Additionally, whole-body functional games can promote aerobic capacity, coordination, and peripheral muscle endurance.
This randomized controlled trial is designed to compare the effects of video game-based rehabilitation combined with conventional physiotherapy versus conventional physiotherapy alone in individuals with mild-to-moderate ILD. A total of 42 participants will be randomized into two parallel arms (intervention and control). The intervention arm will receive supervised video game-based exercise sessions in addition to standard pulmonary rehabilitation, while the control arm will perform conventional home-based physiotherapy and rehabilitation only.
Primary outcomes include changes in respiratory function parameters, functional exercise capacity, and symptom perception before and after the 8-week intervention. The study also aims to examine whether video game-based rehabilitation increases adherence and completion rates compared to conventional programs.
The expected impact of this study is to provide scientific evidence regarding the feasibility, safety, and effectiveness of integrating video game-based rehabilitation into pulmonary rehabilitation for ILD. If successful, this approach may help overcome barriers to participation, improve functional outcomes, and support broader implementation of engaging, patient-centered rehabilitation strategies.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Video game-based exercise training
In addition to the unsupervised conventional pulmonary rehabilitation program, they will participate in a supervised video game-based exercise protocol twice a week.
The conventional physiotherapy and rehabilitation program will include posture exercises combined with breathing exercises three times a day, every weekday, and a walking program twice a week, along with breathing exercises. The supervised video game-based exercise program will include five different five-minute breathing labs and breathing games, two days a week, and 40 minutes of Nintendo Wii Fit games, which include lower extremity, upper extremity, and balance exercises.
Virtual reality exercises
Program Duration: 8 weeks Implementation: The conventional program plus supervised video game-based training sessions.
Additional Protocol: Video Game-Based Exercises
1. Breathing Labs - Breathing Games (Slovenia) Frequency: 3 days per week, on non-walking days, supervised at the hospital. Structure: 5 mini-games per session, performed sequentially.
Exercises:
Balloon: Weeks 1-4: Level 1; Weeks 5-8: Level 2. Focus on sustained controlled exhalation.
Plane: Weeks 1-4: \~6 sec breath cycle; Weeks 5-8: \~8 sec breath cycle. Wolf: Weeks 1-4: Easy; Weeks 5-8: Medium. Flowers: Weeks 1-4: Sunflower module; Weeks 5-8: Rose module. Pluto: Weeks 1-4: Easy; Weeks 5-8: Medium. Intensity: Target MBS 4-6/10 for dyspnea and fatigue.
2. Nintendo Wii / Wii Fit - Functional Training Duration: \~5 minutes per game, 30-40 minutes total per session.
Games and targets:
Lower limb/aerobic: Basic Run, Basic Step, Obstacle Course, Island Cycling. Upper limb: Boxing, Canoe. Balance: Rhythm Parade.
Conventional Pulmonary Rehabilitation
Only the unsupervised conventional pulmonary rehabilitation (PR) program will be applied on this group. The conventional PR program will include posture exercises combined with breathing exercises three times a day, every weekday, and a walking program twice a week, along with breathing exercises
Conventional PR program including:
Breathing exercises (pursed-lip breathing, thoracic expansion, diaphragmatic breathing, breathing control) Postural exercises combined with breathing Walking program (30 min, 2×/week at Borg scale 4-6)
Home exercises
Program Duration: 8 weeks Implementation: Home-based, instructed face-to-face at baseline by a physiotherapist, supported with video materials, and monitored with regular feedback.
A) Posture + Breathing Exercises Frequency: 3 sessions per day (morning, noon, evening)
Content:
Shoulder girdle mobilization: Scapular elevation-depression, abduction-adduction (3 sets × 3 repetitions).
Stretching exercises: Shoulder, cervical, and trunk muscles; 5-second hold at end range.
Combined with breathing: Inspiration during concentric phase, expiration during eccentric phase.
B) Breathing Exercises Frequency: 3 sessions per day; 10 repetitions of each exercise per session
Content:
Pursed-Lip Breathing, Thoracic Expansion Exercises, Diaphragmatic Breathing, Breathing Control C) Walking Program Frequency: 2 days per week Duration: 30 minutes (5 min warm-up, 20 min walking, 5 min cool-down) Intensity: Self-selected pace targeting Modified Borg Scale (MBS) 4-6/10 for dyspnea.
Interventions
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Virtual reality exercises
Program Duration: 8 weeks Implementation: The conventional program plus supervised video game-based training sessions.
Additional Protocol: Video Game-Based Exercises
1. Breathing Labs - Breathing Games (Slovenia) Frequency: 3 days per week, on non-walking days, supervised at the hospital. Structure: 5 mini-games per session, performed sequentially.
Exercises:
Balloon: Weeks 1-4: Level 1; Weeks 5-8: Level 2. Focus on sustained controlled exhalation.
Plane: Weeks 1-4: \~6 sec breath cycle; Weeks 5-8: \~8 sec breath cycle. Wolf: Weeks 1-4: Easy; Weeks 5-8: Medium. Flowers: Weeks 1-4: Sunflower module; Weeks 5-8: Rose module. Pluto: Weeks 1-4: Easy; Weeks 5-8: Medium. Intensity: Target MBS 4-6/10 for dyspnea and fatigue.
2. Nintendo Wii / Wii Fit - Functional Training Duration: \~5 minutes per game, 30-40 minutes total per session.
Games and targets:
Lower limb/aerobic: Basic Run, Basic Step, Obstacle Course, Island Cycling. Upper limb: Boxing, Canoe. Balance: Rhythm Parade.
Home exercises
Program Duration: 8 weeks Implementation: Home-based, instructed face-to-face at baseline by a physiotherapist, supported with video materials, and monitored with regular feedback.
A) Posture + Breathing Exercises Frequency: 3 sessions per day (morning, noon, evening)
Content:
Shoulder girdle mobilization: Scapular elevation-depression, abduction-adduction (3 sets × 3 repetitions).
Stretching exercises: Shoulder, cervical, and trunk muscles; 5-second hold at end range.
Combined with breathing: Inspiration during concentric phase, expiration during eccentric phase.
B) Breathing Exercises Frequency: 3 sessions per day; 10 repetitions of each exercise per session
Content:
Pursed-Lip Breathing, Thoracic Expansion Exercises, Diaphragmatic Breathing, Breathing Control C) Walking Program Frequency: 2 days per week Duration: 30 minutes (5 min warm-up, 20 min walking, 5 min cool-down) Intensity: Self-selected pace targeting Modified Borg Scale (MBS) 4-6/10 for dyspnea.
Eligibility Criteria
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Inclusion Criteria
* Being between the ages of 20 and 70
* Being referred to the study by their physician
* Being willing and able to participate
* Having no physical or cognitive disability that would prevent them from participating in exercise training
Exclusion Criteria
* Presence of cognitive impairment that prevents participation in exercise training
* Presence of a history of cerebrovascular accident
* Presence of a history of cancer
20 Years
70 Years
ALL
No
Sponsors
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Istinye University
OTHER
Responsible Party
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Zeynep Kaçar Akkoç
Principal Investigator
Other Identifiers
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2025/353
Identifier Type: -
Identifier Source: org_study_id