Stimulating Percutaneous Array for Urinary Reflex Control (SPARC)

NCT ID: NCT07149103

Last Updated: 2025-08-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-08-29

Study Completion Date

2026-01-30

Brief Summary

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The Confidanz Smart Patch System consists of a Smart Patch containing one transcutaneous gel electrode and one percutaneous microneedle array electrode that sits directly superficial to the posterior tibial nerve. An applicator is used by the patient to deploy the microneedles into the skin. A Capital Stimulation Unit (CSU) is magnetically aligned with the Smart Patch and generates biphasic current wave form to the posterior tibial nerve through the patch. The CSU is connected to a mobile application via Bluetooth, allowing control over the stimulation intensity parameters.

Primary Objective: To investigate the safety of the Confidanz Smart Patch System for adults diagnosed with idiopathic overactive bladder.

Secondary Objective: To measure the reduction from baseline in average incontinence events (IE) per day at 6- and 12-weeks.

Primary Hypothesis: The use of the Confidanz Smart Patch System is safe for use in adults with idiopathic overactive bladder.

Detailed Description

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The Clinical Trial is a Randomised, single-blinded, sham-controlled study designed to assess the safety and performance of the Confidanz Smart Patch System for home-based intermittent use under clinical supervision, in patients with overactive bladder systems. Participant screening will occur at least 3-days prior to the baseline visit in the clinic. Participants who meet all the inclusion criteria and none of the exclusion criteria will be enrolled. Up to 40 participants will be enrolled in this clinical investigation. A computer-generated sequence will be created using a block randomisation method, participants will be randomised in a 3:1 fashion.

At the baseline visit, the investigator or study staff member will train the participant on the correct use of the device. At-home weekly treatments will be conducted for 12 weeks, here the patient will apply the Smart Patch and initiate a 30-minute stimulation session through the mobile application. The treatment arm will receive stimulation, whereas the control arm will not. Symptom tracking and adverse events will be recorded.

A maximum total of 12 weekly treatments will be conducted. At baseline, 6 and 12 weeks, a 3-day bladder diary, International Consultation on Incontinence Questionnaire (ICIQ), the Overactive Bladder Symptom Score (OABSS), Short Form Survey SF-12, Patient Global Impression of Change (PGI-C), VAS pain scale, and participant decision-making and feedback questionnaire will be administered in the clinic.

Conditions

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Over Active Bladder

Keywords

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Over active bladder Incontinence Ideopathic Over active bladder Percutaneous Tibial Nerve Stimulation (PTNS)

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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Treatment Arm

The treatment arm will undergo the experimental treatment

Group Type EXPERIMENTAL

Percutaneous Tibial Nerve Stimulation

Intervention Type OTHER

By wearing the Confidanz Smart Patch, the Tibial Nerve will be stimulated

SHAM ARM

The sham arm will undergo the same procedure as the treatment group but the therapy will not be switched on

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type OTHER

No active stimulation will be provided

Interventions

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Percutaneous Tibial Nerve Stimulation

By wearing the Confidanz Smart Patch, the Tibial Nerve will be stimulated

Intervention Type OTHER

Placebo

No active stimulation will be provided

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Willing and able to give informed consent for participation in the investigation
2. Is aged 18 years or older
3. Has been diagnosed with idiopathic overactive bladder (OAB) by a qualified urologist (FRACS) or gynaecologist (FRANZCOG)
4. Eligibility is based on meeting the criteria for an OAB, defined by the International Continence Society as an average urinary frequency: ≥8 voids and ≥1 urgency episode (with or without incontinence) per 24 hours
5. Clinically acceptable laboratory results within 30 days of enrolment Urinalysis: Dipstick (Leukocytes \& Nitrites)
6. In the Investigator's opinion, participant is able and willing to comply with all trial requirements
7. Willing to allow their general practitioner and/or other specialists to be aware of their participation in the trial.

Exclusion Criteria

1. Presence of urinary tract infection based on a positive dipstick AND positive mid-stream urine (MSU) test within 4 weeks prior to therapy commencement.
2. Female participant who is pregnant, lactating or planning pregnancy during the trial.
3. History of bladder augmentation/cystoplasty
4. Morbid obesity (BMI greater than 35)
5. Poorly controlled diabetes mellitus (HbA1c \> 7.5% (based on diabetic study)
6. Intravesical injection of botulinum toxin within 12 months of study enrolment.
7. Patients who have failed intravesical Botox therapy.
8. Patients with neurogenic lower urinary tract dysfunction or relevant neurological disease
9. A treatment within the previous year of neuromodulation (TNS or sacral neuromodulation) for OAB.
10. Participant with pacemakers or implantable defibrillators, or other active implantable devices (e.g., spinal cord stimulators, bladder neurostimulators)
11. Participant who have participated in another research trial involving an investigational product in the past 12 weeks.
12. Participant on medication therapy for OAB who have not gone through a two-week washout period during which time medications were discontinued.
13. Participant is in the investigators opinion, unable to comply with trial requirements.
14. Participant has inflamed, infected or otherwise compromised skin in the treatment area.
15. Participant with a bleeding disorder e.g., haemophilia
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Australis Scientific PTY LTD

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Vincent Tse Pty Ltd

Chatswood, New South Wales, Australia

Site Status

AndroUrology Centre

Spring Hill, Queensland, Australia

Site Status

Countries

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Australia

Central Contacts

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Nigel D'Silva

Role: CONTACT

Phone: +61466411877

Email: [email protected]

Facility Contacts

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Wing Ming Vincent TSE, PROFESSOR

Role: primary

Eric Chung, PROFESSOR

Role: primary

Other Identifiers

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CP-001

Identifier Type: -

Identifier Source: org_study_id