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NCT07148908

Animal and Microbial-based Dietary Protein Efficiency in Adults

NCT ID: NCT07148908

Last Updated: 2025-08-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

13 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-07-01

Study Completion Date

2025-12-31

Brief Summary

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Given the relatively high carbon footprint and sustainability of animal-based proteins, there is a growing interest in determining the nutritional quality non-animal-based protein sources. The overall objective of this investigation is to examine the impact of different animal and microbial-based protein sources to support whole body protein synthesis in adults. To do this, investigators will employ a 'breath test' method developed in our laboratory as well as urine sampling. The results of this study will allow us to better understand the impact of dietary protein quality for maintaining health and body protein mass in adults.

Detailed Description

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Conditions

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Protein Metabolism

Keywords

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Protein quality protein metabolism stable isotopes protein oxidation indicator amino acid oxidation protein synthesis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Single-blind randomized, counterbalanced design

Thirteen healthy young (18-45 years of age, at least 6 females and 6 males) will be subjected to a non-invasive 13CO2 breath-test based on the indicator amino acid oxidation method and urine collections following hourly ingestion of protein test beverages (whey, yeast, and collagen randomized by trials).

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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Yeast Protein Supplement

Participants will be consuming test beverage composed of yeast protein and their whole-body protein metabolism will be determined over the subsequent 8 hours.

Group Type EXPERIMENTAL

Yeast Protein Supplement

Intervention Type DIETARY_SUPPLEMENT

Each protein will be consumed at 0.9g/kg/d in n=8 hourly drinks

Whey Protein Isolate Supplement

Participants will be consuming test beverage composed of whey protein isolate and their whole-body protein metabolism will be determined over the subsequent 8 hours.

Group Type ACTIVE_COMPARATOR

Whey Protein Isolate Supplement

Intervention Type DIETARY_SUPPLEMENT

Each protein will be consumed at 0.9g/kg/d in n=8 hourly drinks

Collagen Hydrolysate Supplement

Participants will be consuming test beverage composed of collagen protein and their whole-body protein metabolism will be determined over the subsequent 8 hours.

Group Type ACTIVE_COMPARATOR

Collagen Hydrolysate Supplement

Intervention Type DIETARY_SUPPLEMENT

Each protein will be consumed at 0.9g/kg/d in n=8 hourly drinks

Interventions

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Yeast Protein Supplement

Each protein will be consumed at 0.9g/kg/d in n=8 hourly drinks

Intervention Type DIETARY_SUPPLEMENT

Whey Protein Isolate Supplement

Each protein will be consumed at 0.9g/kg/d in n=8 hourly drinks

Intervention Type DIETARY_SUPPLEMENT

Collagen Hydrolysate Supplement

Each protein will be consumed at 0.9g/kg/d in n=8 hourly drinks

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Healthy, male and female, recreationally-active participants.
* Healthy will be defined as screened by the PAR-Q+ (Appendix B) and The Physical Activity Readiness Questionnaire (Appendix C).
* Participants will be aged 18-45 years old.
* Participants are willing to abide by the compliance rules of this study.
* Self-reported regular menstrual cycle (25-35d) within the last 3 months (female participants).
* Use of monophasic combined oral contraceptives (COC) containing 21 active pills (e.g., Yaz, Marvelon, Cyclen, etc.; the brand of COC will be recorded) (female participants).

Exclusion Criteria

* Inability to adhere to any of the compliance rules judged by principal investigator (e.g. dairy protein or yeast allergy).
* Self-reported regular tobacco use.
* Self-reported illicit drug use (e.g., growth hormone, testosterone, etc.).
* Individuals who have participated in studies within the past year involving any of the stable isotopes in the study.
* Use of multiphasic COCs due to the difficulty of controlling for hormonal fluctuations in such formulations (female participants).
* Use of COCs containing \>21 active pills per cycle due to potential differences in their effect on metabolism (female participants).
* Use of other forms of hormonal contraception (e.g., progestin-only pill, hormonal IUD, intravaginal ring) (female participants).
* Not currently or previously (in the past 6 months) on a vegan diet

Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Lesaffre International

INDUSTRY

Sponsor Role collaborator

Daniel Moore

OTHER

Sponsor Role lead

Responsible Party

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Daniel Moore

Principal Investigator

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Kinesiology & Physical Education

Toronto, Ontario, Canada

Site Status RECRUITING

Countries

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Canada

Central Contacts

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Daniel R. Moore, Ph.D.

Role: CONTACT

Phone: 416-946-4088

Email: [email protected]

Facility Contacts

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Sabrina T. Barsky, Ph.D.

Role: primary

Other Identifiers

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REB00048239

Identifier Type: -

Identifier Source: org_study_id