Tedizolid Neuropathies

NCT ID: NCT07143240

Last Updated: 2025-08-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

5 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-03-01

Study Completion Date

2025-05-01

Brief Summary

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Tedizolid is a new oxazolidinone, related to linezolid. It has obtained marketing authorization for the treatment of skin and soft tissue infections. Its potential interest compared to linezolid lies mainly in its better tolerance in the context of more prolonged treatments required in chronic Gram-positive cocci infections such as osteoarticular infections. Indeed, linezolid has hematological toxicity, appearing beyond 10 days of treatment. Due to a lower dosage and lower mitochondrial toxicity, the hematological tolerance of tedizolid is better, even allowing it to be used as a relay from linezolid after the occurrence of hematotoxicity. Another side effect of the oxazolidinone class is the occurrence of optic and peripheral neuropathies observed under linezolid. The pharmacological properties of tedizolid and in vitro and in vivo data suggested a lower risk of neurotoxicity, although a few cases have been published..

Detailed Description

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Conditions

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Adult Patients Developing Optic or Peripheral Neuropathy While Receiving Tedizolid Therapy Between July 2019 and December 2024

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Adult patients developing optic or peripheral neuropathy while receiving tedizolid therapy

The study population included subjects aged ≥ 18 years who received tedizolid for infections between July 2019 and December 2024.

Subjects younger than 18 years old were excluded.

Determine patient demographic and clinical characteristics at baseline

Intervention Type OTHER

Description of demographic data (sex, age), comorbidities (Charlson scores), septic history, clinical data relating to neuropathy, and tedizolid prescription modalities (dose, duration).

Interventions

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Determine patient demographic and clinical characteristics at baseline

Description of demographic data (sex, age), comorbidities (Charlson scores), septic history, clinical data relating to neuropathy, and tedizolid prescription modalities (dose, duration).

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* 18 years
* Patients developing optic or peripheral neuropathy while receiving tedizolid therapy

Exclusion Criteria

* 18 years
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hospices Civils de Lyon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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HCL

Lyon, France, France

Site Status

Countries

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France

Other Identifiers

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25-5138

Identifier Type: -

Identifier Source: org_study_id

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