OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events
NCT ID: NCT07136012
Last Updated: 2025-10-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
PHASE3
11000 participants
INTERVENTIONAL
2025-08-22
2031-10-20
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Olpasiran
Participants will receive subcutaneous (SC) olpasiran.
Olpasiran
Olpasiran will be administered via SC injection.
Placebo
Participants will receive SC placebo.
Placebo
Placebo will be administered via SC injection.
Interventions
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Olpasiran
Olpasiran will be administered via SC injection.
Placebo
Placebo will be administered via SC injection.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Lp(a)≥ 200 nmol/L during screening
* Multiple atherosclerotic cardiovascular disease risk factors, and/or evidence of atherosclerosis
Exclusion Criteria
* Prior or planned arterial revascularization
* History of major bleeding disorder
50 Years
105 Years
ALL
No
Sponsors
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Amgen
INDUSTRY
Responsible Party
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Principal Investigators
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MD
Role: STUDY_DIRECTOR
Amgen
Locations
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Advanced Cardiovascular LLC
Alexander City, Alabama, United States
Alliance For Multispecialty Research - Daphne
Daphne, Alabama, United States
Eastern Shore Research Institute
Fairhope, Alabama, United States
Heart Center Research LLC
Huntsville, Alabama, United States
CB Flock Research Corporation
Mobile, Alabama, United States
Phoenix Clinical
Phoenix, Arizona, United States
Elite Clinical Studies LLC
Phoenix, Arizona, United States
HonorHealth Research Institute
Scottsdale, Arizona, United States
Eclipse Clinical Research
Tucson, Arizona, United States
National Heart Institute
Beverly Hills, California, United States
310 Clinical Research
Inglewood, California, United States
Valley Clinical Trials
Northridge, California, United States
Clinical Trials Research - Sacramento
Roseville, California, United States
Alliance Clinical Research
San Diego, California, United States
Encompass Clinical Research
Spring Valley, California, United States
Manshadi Heart Institute
Stockton, California, United States
Blue Coast Cardiology
Vista, California, United States
Diablo Clinical Research
Walnut Creek, California, United States
Focus Clinical Research
West Hills, California, United States
South Denver Cardiology Associates
Littleton, Colorado, United States
Chase Medical Research LLC
Waterbury, Connecticut, United States
Excel Medical Clinical Trials
Boca Raton, Florida, United States
Clearwater Cardiovascular Consultants
Clearwater, Florida, United States
Proactive Clinical Research
Fort Lauderdale, Florida, United States
Indago Research and Health Center
Hialeah, Florida, United States
Elite Cardiac Research Center LLC
Hialeah, Florida, United States
Jacksonville Center for Clinical Research
Jacksonville, Florida, United States
East Coast Institute for Research, LLC
Lake City, Florida, United States
Columbus Clinical Services LLC
Miami, Florida, United States
Kendall South Medical Center
Miami, Florida, United States
Inpatient Research Clinic, LLC
Miami Lakes, Florida, United States
Panax Clinical Research
Miami Lakes, Florida, United States
Eminat, LLC
Miramar, Florida, United States
Suncoast Clinical Research Inc
New Port Richey, Florida, United States
Ocala Cardiovascular Research
Ocala, Florida, United States
Ocala Research Institute, Inc
Ocala, Florida, United States
Ormond Beach Clinical Research
Ormond Beach, Florida, United States
Emory University Hospital
Atlanta, Georgia, United States
East Coast Institute for Research
Canton, Georgia, United States
Nsc Research
Johns Creek, Georgia, United States
St Lukes Idaho Cardiology Associates
Meridian, Idaho, United States
Solaris Clinical Research
Meridian, Idaho, United States
Alliance for Multispecialty Research, LLC - Park Ridge
Park Ridge, Illinois, United States
MediSphere Medical Research Center LLC
Evansville, Indiana, United States
Franciscan Health Indianapolis
Indianapolis, Indiana, United States
Cardiovascular Research of Northwest Indiana LLC
Munster, Indiana, United States
Reid Physician Associates
Richmond, Indiana, United States
Hutchinson Clinic PA
Hutchinson, Kansas, United States
Midwest Heart and Vascular Specialists
Overland Park, Kansas, United States
Graves Gilbert Clinic
Bowling Green, Kentucky, United States
The Research Group of Lexington LLC
Lexington, Kentucky, United States
Ima Clinical Research
Monroe, Louisiana, United States
Louisiana Heart Center
Slidell, Louisiana, United States
Monroe Research LLC
West Monroe, Louisiana, United States
Ascension Saint Agnes Heart Care
Baltimore, Maryland, United States
Johns Hopkins Hospital
Baltimore, Maryland, United States
Metropolitan Cardiovascular Consultants LLC
Beltsville, Maryland, United States
Flourish Research
Bowie, Maryland, United States
Centennial Medical Group
Columbia, Maryland, United States
Capitol Cardiology Associates
Lanham, Maryland, United States
Advanced Cardiology Associates
Rochester Hills, Michigan, United States
Revival Research Institute
Southfield, Michigan, United States
Sisters of Saint Mary Health Heart and Vascular Care
Bridgeton, Missouri, United States
Excel Clinical Research
Las Vegas, Nevada, United States
American Institute of Medical Research
Las Vegas, Nevada, United States
Las Vegas Clinical Trials
North Las Vegas, Nevada, United States
Renown Institute for Heart and Vascular Health
Reno, Nevada, United States
New Jersey Medcare / New Jersey Heart
Linden, New Jersey, United States
Circuit Clinical / Optum Medical Care of New Jersey
Secaucus, New Jersey, United States
CardioMetabolic Collaborative Clinic
Somerset, New Jersey, United States
Ima Clinical Research - Warren
Warren Township, New Jersey, United States
Albany Medical College
Albany, New York, United States
Crystal Run Healthcare
Monroe, New York, United States
Niagara Falls Memorial Medical Center
Niagara Falls, New York, United States
Orchard Park Family Pracitce
Orchard Park, New York, United States
Medication Management LLC
Greensboro, North Carolina, United States
Triad Clinical Trials, LLC
Greensboro, North Carolina, United States
Monroe Biomedical Research
Monroe, North Carolina, United States
Accellacare Research of Wilmington
Wilmington, North Carolina, United States
Aultman Cardiology Clinical Trials
Canton, Ohio, United States
The Christ Hospital
Cincinnati, Ohio, United States
Velocity Clinical Research - Cincinnati
Cincinnati, Ohio, United States
Nexgen Research
Lima, Ohio, United States
K and R Research
Marion, Ohio, United States
Alliance for Multispecialty Research
Norman, Oklahoma, United States
Pottstown Medical Specialists Inc
Pottstown, Pennsylvania, United States
Pharmacorp Clinical Trials Inc
Charleston, South Carolina, United States
Walker Family Care
Little River, South Carolina, United States
Accellacare Charleston
Mt. Pleasant, South Carolina, United States
Tribe Clinical Research - Spartanburg
Spartanburg, South Carolina, United States
Apex Research Foundation, LLC
Jackson, Tennessee, United States
Alliance for Multispecialty Research Knoxville
Knoxville, Tennessee, United States
Tennessee Center for Clinical Trials
Tullahoma, Tennessee, United States
PharmaTex Research, LLC
Amarillo, Texas, United States
Texas Diabetes and Endocrinology
Austin, Texas, United States
Ima Clinical Research
Austin, Texas, United States
Zenos Clinical Research
Dallas, Texas, United States
Cedar Health Research, LLC
Euless, Texas, United States
East Texas Cardiology PA
Houston, Texas, United States
Cardiovascular Specialists of Willowbrook
Houston, Texas, United States
Vital Heart and Vein
Humble, Texas, United States
Tcr Institute Llc
Kingwood, Texas, United States
Epic Clinical Research
Lewisville, Texas, United States
North Dallas Research Associates
McKinney, Texas, United States
Texas Institute of Cardiology
McKinney, Texas, United States
Southern Endocrinology Associates PA
Mesquite, Texas, United States
Orion Medical
Pasadena, Texas, United States
Ima Clinical Research San Antonio
San Antonio, Texas, United States
Tyler Cardiovascular Consultants
Tyler, Texas, United States
Carient Heart and Vascular
Manassas, Virginia, United States
Tidewater Physicians Multispecialty Group Clinical Research
Newport News, Virginia, United States
Alliance for Multispecialty Research Norfolk
Norfolk, Virginia, United States
Centricity Research
Suffolk, Virginia, United States
Selma Medical Associates
Winchester, Virginia, United States
Winchester Medical Center
Winchester, Virginia, United States
Royal Prince Alfred Hospital
Camperdown, New South Wales, Australia
Novatrials
Charlestown, New South Wales, Australia
Concord Repatriation General Hospital
Concord, New South Wales, Australia
Aim Research
Merewether, New South Wales, Australia
Orange Health Service
Orange, New South Wales, Australia
Advara HeartCare Wesley
Auchenflower, Queensland, Australia
Core Research Group Pty Ltd
Milton, Queensland, Australia
University of The Sunshine Coast Clinical Trials, Sippy Downs
Sippy Downs, Queensland, Australia
Dr Heart Pty Ltd
Woolloongabba, Queensland, Australia
Flinders Medical Centre
Bedford Park, South Australia, Australia
Advara HeartCare Leabrook
Leabrook, South Australia, Australia
Fusion Clinical Research
Norwood, South Australia, Australia
Victorian Heart Hospital
Clayton, Victoria, Australia
The Alfred Hospital
Melbourne, Victoria, Australia
Momentum Clinical Research - Sunshine
Melbourne, Victoria, Australia
Advara HeartCare Joondalup
Joondalup, Western Australia, Australia
Linear Clinical Research Limited
Nedlands, Western Australia, Australia
Centricity Research Calgary
Calgary, Alberta, Canada
Fraser Clinical Trials
New Westminster, British Columbia, Canada
SMH Cardiology Clinical Trials Incorporated
Surrey, British Columbia, Canada
ARC Biosystems Incorporated
Vancouver, British Columbia, Canada
Discovery Clinical Services Ltd
Victoria, British Columbia, Canada
Centricity Research Brampton
Brampton, Ontario, Canada
Premier Clinical Trial Network
Hamilton, Ontario, Canada
Partners in Advanced Cardiac Evaluation
Newmarket, Ontario, Canada
North York Diagnostic and Cardiac Centre
North York, Ontario, Canada
Oakville Cardiovascular Research
Oakville, Ontario, Canada
Heart Health Institute Research Incorporated
Scarborough Village, Ontario, Canada
Ecogene-21
Chicoutimi, Quebec, Canada
CIUSSS de l Estrie CHUS Hopital Fleurimont
Sherbrooke, Quebec, Canada
Countries
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Central Contacts
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Related Links
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AmgenTrials clinical trials website
Other Identifiers
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20230222
Identifier Type: -
Identifier Source: org_study_id