Construction and Application of Precise Diagnosis and Treatment System for Thyroid-associated Ophthalmopathy

NCT ID: NCT07124572

Last Updated: 2025-08-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-10-01

Study Completion Date

2031-10-01

Brief Summary

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This study aims to develop the deep learning-based system that integrates multimodal information to automatically diagnose, stage, and grade thyroid-associated ophthalmopathy (TAO), assist in treatment decision-making, and predict patient prognosis, thereby providing novel tools to support clinical management.

Detailed Description

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Conditions

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Thyroid Associated Ophthalmopathy

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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Participants without Thyroid-associated ophthalmopathy

Participants without thyroid-associated ophthalmopathy based on Bartley criteria.

Imaging and ocular examinations

Intervention Type OTHER

2D and 3D Facial photography, blinking videos, orbital CT and MRI images, fundus images and images of nine gaze positions are taken.

Clinical information is recorded. Quality of life is assessed. Ocular examinations, such as visual acuity, levator function, exophthalmos measurement, strabismus test, visual field examination, axial length measurement, OCT, OCTA are made.

Patients with Thyroid-associated ophthalmopathy

Patients diagnosed as thyroid-associated ophthalmopathy based on Bartley criteria.

Imaging and ocular examinations

Intervention Type OTHER

2D and 3D Facial photography, blinking videos, orbital CT and MRI images, fundus images and images of nine gaze positions are taken.

Clinical information is recorded. Quality of life is assessed. Ocular examinations, such as visual acuity, levator function, exophthalmos measurement, strabismus test, visual field examination, axial length measurement, OCT, OCTA are made.

Interventions

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Imaging and ocular examinations

2D and 3D Facial photography, blinking videos, orbital CT and MRI images, fundus images and images of nine gaze positions are taken.

Clinical information is recorded. Quality of life is assessed. Ocular examinations, such as visual acuity, levator function, exophthalmos measurement, strabismus test, visual field examination, axial length measurement, OCT, OCTA are made.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* normal participants without eyelid disorders (control group)
* patients with thyroid-associated ophthalmopathy (TAO group)
* cooperative participants

Exclusion Criteria

* participants with pupil or cornea disorders
* participants with history of eye injury
Minimum Eligible Age

7 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Second Affiliated Hospital, School of Medicine, Zhejiang University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Juan Ye

Hangzhou, Zhejiang, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Juan Ye

Role: CONTACT

+86-571-87783897

Facility Contacts

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Juan Ye

Role: primary

+81-0571-87783897

Other Identifiers

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2022-0592

Identifier Type: -

Identifier Source: org_study_id

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