Biological Drivers of Cervical Cancer and Side Effects From Radiation Therapy
NCT ID: NCT07121543
Last Updated: 2025-08-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
20 participants
OBSERVATIONAL
2025-08-04
2027-08-31
Brief Summary
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Does radiation therapy alter the expression of tissue factor and other molecules in cervical cancer over time?
Participants already scheduled for radiation therapy for cervical cancer as part of their regular medical care will provide blood and biopsies of cervical cancer or of the upper portion of the vagina before, during, and on the last day of radiation therapy.
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Detailed Description
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In this study, the investigators will use tissue and blood from patients with cervical cancer to perform translational research. This is necessary to discover molecular pathways that could be targeted in the future with novel agents, such as radiotherapy and immunotherapy, for the treatment of women with cervical cancer.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Cervical cancer biopsy
Using tumor biopsies collected before, during, and after radiotherapy, the investigators will:
1. Evaluate if irradiation alters tissue factor expression in tumors.
2. Determine the temporal changes of biomarkers in the irradiated tumor immune microenvironment.
Brachytherapy
Brachytherapy is a cancer treatment where radioactive sources are placed inside or near the tumor.
Vaginal apex biopsy
Using vaginal tissue biopsies collected before, during, and after radiotherapy, the investigators will:
1. Evaluate if irradiation alters biomarkers of fibrosis in the vaginal tissue.
2. Determine the temporal changes of inflammatory biomarkers that increases the stenosis molecular cascade in the irradiated tumor immune microenvironment.
Brachytherapy
Brachytherapy is a cancer treatment where radioactive sources are placed inside or near the tumor.
Interventions
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Brachytherapy
Brachytherapy is a cancer treatment where radioactive sources are placed inside or near the tumor.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Pathological diagnosis of cervical cancer
* Scheduled to receive brachytherapy for cervical cancer
Exclusion Criteria
* Inability to provide a tissue sample
18 Years
FEMALE
No
Sponsors
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University of California, San Diego
OTHER
Responsible Party
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Jyoti Mayadev, MD
Professor, Radiation Medicine and Applied Sciences
Principal Investigators
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Jyoti Mayadev, MD
Role: PRINCIPAL_INVESTIGATOR
University of California, San Diego
Locations
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University of California San Diego
La Jolla, California, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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811012
Identifier Type: -
Identifier Source: org_study_id
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