SMC Radiation Oncology SABR Cohort for Oligometastasis

NCT ID: NCT07121335

Last Updated: 2025-08-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-05-01

Study Completion Date

2030-03-31

Brief Summary

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The goal of this observational study is to evaluate the efficacy and safety of stereotactic body radiotherapy (SABR) in patients with oligometastatic or oligoprogressive cancer.

The main questions it aims to answer are:

1. oncologic outcomes (progression-free survival, local failure rate),
2. patient-reported outcomes,
3. physician-assessed toxicity, and
4. dynamics of circulating tumor DNA (ctDNA) for biomarker analysis.

Detailed Description

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Conditions

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Stereotactic Body Radiation Therapy (SBRT) Oligometastasis Oligoprogression ctDNA Patient-Reported Outcomes (PRO)

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Stereotactic body radiotherapy (SBRT)

Stereotactic body radiotherapy (SABR) using photon or proton beams will be delivered per standard practice (1-5 fractions).

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

* Performance status (ECOG PS) 0-2
* Diagnosed with metastatic disease
* Confirmed to have oligometastatic/oligoprogressive cancer on imaging performed within 4 weeks (up to 5 lesions)

Exclusion Criteria

* Patient with a history of prior radiotherapy to the site planned for SABR
* Patients with concomitant brain metastases
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Samsung Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Nalee Kim

Assistant professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Samsung medical center

Seoul, , South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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Nalee Kim, MD, PhD

Role: CONTACT

82-2-3410-2612

Facility Contacts

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Nalee Kim

Role: primary

82-2-3410-2612

Other Identifiers

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SMC 2025-03-037

Identifier Type: -

Identifier Source: org_study_id

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