A Phase III Study of SHR-A1811 in Combination With Chemotherapy and Adebrelimab in Previously Untreated Patients With Gastric or Gastroesophageal Junction Adenocarcinoma

NCT ID: NCT07118527

Last Updated: 2025-09-04

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: PHASE3
• Total Enrollment: 600 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-08-18
• Study Completion Date: 2030-10-31

Brief Summary

This study aims to evaluate the efficacy and safety of SHR-A1811 combined with chemotherapy and immune checkpoint inhibitor versus standard first-line therapy in gastric or gastroesophageal junction adenocarcinoma.

Conditions

Patients With Unresectable Locally Advanced or Metastatic Untreated Gastric or Gastroesophageal Junction Adenocarcinoma

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Treatment group A:

SHR-A1811 + Adebrelimab Injection + Capecitabine Tablets or Fluorouracil Injection

Group Type: EXPERIMENTAL

SHR-A1811 + Adebrelimab Injection + Capecitabine Tablets or Fluorouracil Injection

Intervention Type: DRUG

SHR-A1811: intravenous infusion; Adebrelimab Injection: intravenous infusion; Capecitabine Tablets: oral administration Fluorouracil Injection: intravenous infusion

Treatment group B

Trastuzumab + Pembrolizumab + CAPOX( Capecitabine Tablets + Oxaliplatin) or FP (Fluorouracil Injection+Cisplatin)

Group Type: ACTIVE_COMPARATOR

Trastuzumab + Pembrolizumab + CAPOX( Capecitabine Tablets + Oxaliplatin) or FP (Fluorouracil Injection+Cisplatin)

Intervention Type: DRUG

Trastuzumab : intravenous infusion; Pembrolizumab: intravenous infusion; Capecitabine Tablets: oral administration; Oxaliplatin: intravenous infusion; Fluorouracil Injection: intravenous infusion; Cisplatin: intravenous infusion;

Interventions

SHR-A1811 + Adebrelimab Injection + Capecitabine Tablets or Fluorouracil Injection

SHR-A1811: intravenous infusion; Adebrelimab Injection: intravenous infusion; Capecitabine Tablets: oral administration Fluorouracil Injection: intravenous infusion

Intervention Type: DRUG

Trastuzumab + Pembrolizumab + CAPOX( Capecitabine Tablets + Oxaliplatin) or FP (Fluorouracil Injection+Cisplatin)

Trastuzumab : intravenous infusion; Pembrolizumab: intravenous infusion; Capecitabine Tablets: oral administration; Oxaliplatin: intravenous infusion; Fluorouracil Injection: intravenous infusion; Cisplatin: intravenous infusion;

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Aged between 18 and 75 years (inclusive), male or female

2. Histologically or cytologically confirmed untreated, locally advanced, unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma.

3. ECOG performance status score of 0 to 1.

4. Life expectancy ≥12 weeks.

5. Must have at least one measurable lesion according to RECIST v1.1 criteria.

6. Tumor tissue samples must be provided, and newly obtained tumor tissues are preferred.

7. Adequate bone marrow and organ function；

8. Women of childbearing potential must agree on abstinence (avoid heterosexual sex) or use of the highly effective methods of contraception from the signature of informed consent form until at least 7 months after the last dose of the investigational product(s).

9. Male patients whose partners are women of childbearing potential must agree on abstinence or use of the highly effective methods of contraception from the signature of informed consent form until at least 7 months after the last dose of investigational product(s).

10. Capable of giving informed consent, have signed and dated the informed consent approved by the Ethics Committee, and willing and able to comply with tests and other procedures at scheduled visits.

Exclusion Criteria

1. Current or previous meningeal metastases; presence of active brain metastases.

2. Ascites, pleural effusion and pericardial effusion requiring treatment (such as puncture, drainage, etc.) within 2 weeks before randomization.

3. Subjects with other malignant tumors within 3 years before randomization.

4. Have received traditional Chinese medicine with anti-tumor indications within 2 weeks before randomization.

5. With adverse reactions (ARs) from previous anti-tumor treatment that have not recovered to NCI-CTCAE v5.0 Grade ≤ 1.

6. Use of other non-marketed clinical investigational products or interventions within 4 weeks before randomization.

7. Have undergone major surgery (excluding aspiration biopsy) or experienced significant trauma within 4 weeks before randomization.

8. Patients with active autoimmune diseases or history of autoimmune diseases.

9. Patients with known or suspected interstitial lung disease; patients with other severe lung diseases that seriously affect respiratory function within 3 months before randomization.

10. History of active tuberculosis within 1 year before randomization, or history of active tuberculosis over 1 year without appropriate treatment.

11. History of immunodeficiency, including positive HIV test; active hepatitis B or hepatitis C.

12. Patients who have previously undergone allogeneic hematopoietic stem cell transplantation or organ transplantation.

13. Severe cardiovascular or cerebrovascular diseases.

14. Clinically significant bleeding symptoms or significant bleeding tendency within 3 months before randomization.

15. Gastrointestinal perforation, gastrointestinal fistula or abdominal infection within 3 months before randomization.

16. Uncontrollable tumor-related pain or symptomatic hypercalcemia.

17. Patients with Grade > 1 peripheral neuropathy.

18. Vaccination of live attenuated vaccine within 28 days prior to randomization.

19. Previous use of anti-HER2 antibody-drug conjugates.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Suzhou Suncadia Biopharmaceuticals Co., Ltd.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

The First Hospital of China Medical University

Shenyang, Liaoning, China

Site Status: RECRUITING

Zhongshan Hospital，Fudan University

Shanghai, Shanghai Municipality, China

Site Status: RECRUITING

Countries

China

Central Contacts

Shi Wei SUN

Role: CONTACT

Shiwei.sun@hengrui.com

+86 18036618554

Other Identifiers

SHR-A1811-316

Identifier Type: -

Identifier Source: org_study_id