Biomarker-based Alzheimer's Disease Cohort Study (BASIC)

NCT ID: NCT07109999

Last Updated: 2025-08-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

2835 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-01-01

Study Completion Date

2050-12-31

Brief Summary

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This study adopts a prospective cohort design, constructing a single-center cohort by recruiting patients with Alzheimer's disease (AD) who are positive for AD biomarkers. First, the investigators aim to establish a cohort of AD patients with positive biomarkers, thereby reserving suitable patient resources for future AD-related clinical trials. Second, based on the established cohort, the investigators will explore the associations between AD-related biomarkers and clinical manifestations among the elderly population in China, and identify potential risk factors influencing the progression of AD. Third, according to the identified risk factors for AD progression, the investigators will construct a risk early warning model for the progression rate of AD based on biomarkers, in order to achieve early identification and precise prevention and control of the progression risk of AD.

Detailed Description

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Conditions

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Alzheimer Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients diagnosed with Alzheimer's disease with AD biomarker positivity.

This cohort recruits patients diagnosed with Alzheimer's disease based on clinical symptoms, neuroimaging features and AD biomarkers. Biomarker positivity is necessary for inclusion.

None-placebo

Intervention Type OTHER

This study is an observational study, and no interventions will be implemented.

Interventions

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None-placebo

This study is an observational study, and no interventions will be implemented.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* (1) Patients aged 40 years or older;
* (2) Visiting Xuanwu Hospital, Capital Medical University;
* (3) Meeting the core clinical diagnostic criteria for Alzheimer's disease (AD) - related mild cognitive impairment or probable AD according to the NIA-AA (2011);
* (4) Amyloid positivity confirmed by amyloid PET or cerebrospinal fluid biomarker tests;
* (5) Providing informed consent.

Exclusion Criteria

* (1) Individuals who are unable to complete the assessment due to severe psychological or physiological disorders.
Minimum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Xuanwu Hospital, Beijing

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Xuanwu Hospital of Capital Medical University

Beijing, Beijing Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Liyang Liu

Role: CONTACT

17888828131

Facility Contacts

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Liu Liyang Liu

Role: primary

17888828131

Other Identifiers

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2024347

Identifier Type: -

Identifier Source: org_study_id

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