Effectiveness of Chlorzoxazone Versus Orphenadrine Citrate in Alleviating Bruxism Pain

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE4

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-07-22

Study Completion Date

2025-08-30

Brief Summary

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To evaluate the clinical effectiveness of chlorzoxazone in comparison to orphenadrine Citrate in relieving the orofacial pain in bruxers. Subjects and Methods: 60 patients above 15-years old complaining of orofacial and temporomandibular disorder/pain, with no history of chronic systemic illness, will be recruited. Patients will randomly be allocated into two groups (n=30): the first group will receive Relaxon (chlorzoxazone) twice daily for two weeks, while the second group will receive Norgesic (orphenadrine Citrate) twice daily for two weeks as well. Pain severity will be assessed by Visual Analogue Scale (VAS) at day 0, 7, and day 14. In addition, a temporomandibular joint (TMJ) evaluation form will be utilized to assess the TMJ parameters before and after initiation of the treatment protocol, i.e at 0 and 14 days. Non parametric statistical analysis will be conducted to explain the results using SPSS V29.

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Detailed Description

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Conditions

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Orofacial Pain Bruxism

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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Chlorzoxazone Group

Using Chlorzoxazone

Group Type ACTIVE_COMPARATOR

Chlorzoxazone

Intervention Type DRUG

This group will receive Chlorzoxazone twice daily for two weeks

Orphenadrine Citrate group

Group Type ACTIVE_COMPARATOR

Orphenadrine Citrate

Intervention Type DRUG

This group will receive Orphenadrine Citrate twice daily for two weeks.

Interventions

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Chlorzoxazone

This group will receive Chlorzoxazone twice daily for two weeks

Intervention Type DRUG

Orphenadrine Citrate

This group will receive Orphenadrine Citrate twice daily for two weeks.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients aged above 15 years-old complaining of orofacial and temporomandibular disorder/pain.
* Patients with no history of chronic systemic illness.