Glycemic Improvement With Team, Technology, Education and Peer Resources in Type 1 Diabetes-GLITTER Study

NCT ID: NCT07097805

Last Updated: 2025-07-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

3000 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-01-01

Study Completion Date

2028-03-01

Brief Summary

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The GLITTER study is comprised of four key components: Team, Technology, Education, and Peer Resources. The aim of the GLITTER Study is to improve the metabolic control rate in patients with type 1 diabetes through a comprehensive management approach.

Detailed Description

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Patients with type 1 diabetes (T1D) face significant glycemic fluctuations, posing substantial challenges in disease management. Current clinical evidence indicates that although interventions such as structured education programs, peer support, and novel diabetes technologies demonstrate positive outcomes when applied individually, the glycemic target attainment rate remains suboptimal, with fewer than 30% achieving this benchmark. To address this clinical dilemma, the investigators has proposed the GLITTER (Glycemic Improvement with Team, Technology, Education and Peer Resources in type 1 diabetes) study, which aims to establish a four-in-one integrated management model combining multidisciplinary collaborative teams, structured educational frameworks, peer support systems, and diabetes technologies. The research team comprises T1D-specialized physicians and diabetes educators. Structured education is delivered through dedicated T1D specialty clinics and by local clinicians. Technological support involves informing patients about access to continuous glucose monitors (CGM) and insulin pumps without mandating their use, while peer support is established through patient communication groups (volunteer matching mechanisms are not yet implemented). This GLITTER study seeks to achieve dual objectives: population-wide coverage and whole-disease-course management for individuals with T1D.

This is a multicenter, prospective, cohort study. This longitudinal investigation systematically collects multidimensional clinical datasets encompassing glycemic control parameters, pancreatic β-cell function, and complication risk profiles through regular follow-up visits. This study explores the metabolic control, psychological outcomes, and their associated influencing factors among patients with T1D.

Conditions

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Type 1 Diabetes (T1D)

Keywords

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Type 1 diabetes Comprehensive management

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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T1D Patients

All patients diagnosed with type 1 diabetes of all ages.

Group Type OTHER

GLITTER comprehensive management

Intervention Type BEHAVIORAL

The GLITTER comprehensive management represents a management approach that effectively combines multidisciplinary professional team care, diabetes technology empowerment, structured education steering, and peer support.

Interventions

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GLITTER comprehensive management

The GLITTER comprehensive management represents a management approach that effectively combines multidisciplinary professional team care, diabetes technology empowerment, structured education steering, and peer support.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

1\. Patients with type 1 diabetes of all age groups, regardless of disease duration.

The diagnosis criteria for type 1 diabetes are met by fulfilling any one point from the first two criteria plus any one point from the third criterion.

1. Clinically diagnosed as Type 1 Diabetes by a specialist physician.
2. Meet any one of the following criteria:

A. Age of onset \<15 years B. No obesity at the time of onset C. diabetic ketoacidosis onset D. Maximum random C-peptide \<200 pmol/L
3. Meet any one of the following criteria:

A. Initiation and continuation of insulin therapy after diagnosis (excluding pancreas or islet transplantation) B. Positive for islet cell antibodies
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Second Xiangya Hospital of Central South University

OTHER

Sponsor Role lead

Responsible Party

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Xia Li

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Department of Endocrinology and Metabolism, Peking University People's Hospital

Beijing, Beijing Municipality, China

Site Status RECRUITING

Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University

Beijing, Beijing Municipality, China

Site Status RECRUITING

Department of Endocrinology and Metabolism, the Third Affiliated Hospital of Sun Yat-sen University

Guangzhou, Guangdong, China

Site Status RECRUITING

Department of Endocrinology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University

Shenzhen, Guangdong, China

Site Status RECRUITING

Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology

Luoyang, Henan, China

Site Status RECRUITING

Institute of Metabolism and Endocrinology, Second Xiangya Hospital of Centra South University

Changsha, Hunan, China

Site Status RECRUITING

Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University

Nanjing, Jiangsu, China

Site Status RECRUITING

Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University

Shenyang, Liaoning, China

Site Status RECRUITING

Department of Endocrinology and Metabolism, Laboratory of Diabetes and metabolism research, West China Hospital, Sichuan University

Chengdu, Sichuan, China

Site Status RECRUITING

Department of Endocrinology, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health

Hangzhou, Zhejiang, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Xia Li

Role: CONTACT

Phone: +86 13974885753

Email: [email protected]

Facility Contacts

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Xiaoling Cai

Role: primary

Chang Liu

Role: primary

Jinhua Yan

Role: primary

Haiyan Li

Role: primary

Hongwei Jiang

Role: primary

Xia Li

Role: primary

Mei Zhang

Role: primary

Yanli Cao

Role: primary

Nanwei Tong

Role: primary

Junfen Fu

Role: primary

Other Identifiers

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KYZ20240193

Identifier Type: -

Identifier Source: org_study_id