Virus Transmission to People Recently Bitten or With a History of Monkey Bites "SIMVIR
NCT ID: NCT07097480
Last Updated: 2025-07-31
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
80 participants
INTERVENTIONAL
2025-07-31
2028-07-31
Brief Summary
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The objective of the study is to investigate the prevalence of STLV-1 and SFV infections following a nonhuman primate bite.
Detailed Description
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Compared to other individuals exposed to nonhuman primates (NHPs), travelers have two unique characteristics. First, they are typically exposed only once to simian infectious agents, in contrast to the repeated exposure experienced by other at-risk groups. If exposure results in an infection event, travelers may spread these infectious agents to geographic areas where they do not normally circulate.
To address the following main objective: to study the prevalence of STLV-1 and SFV infections following a nonhuman primate bite. The study plans to include subjects who have been recently bitten as well as those with a history of nonhuman primate bites. Blood and saliva samples will be collected from the subjects.
Conditions
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Keywords
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Study Design
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NON_RANDOMIZED
PARALLEL
OTHER
NONE
Study Groups
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Adults recently bitten by a non-human primate
Adults recently bitten by a non-human primate and consulting at the Institut Pasteur medical center for prophylaxis as part of their care.
Blood samples collection
Blood samples of 40 ml will be taken.
Saliva samples collection
Saliva samples will be collected
Adults with a history of bites
Adults with a history of bites from a non-human primate who are consulting at the Institut Pasteur medical center as part of their routine care.
Blood samples collection
Blood samples of 40 ml will be taken.
Saliva samples collection
Saliva samples will be collected
Interventions
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Blood samples collection
Blood samples of 40 ml will be taken.
Saliva samples collection
Saliva samples will be collected
Eligibility Criteria
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Inclusion Criteria
* Bite inflicted by an HNP (WHO category 3 level)
* Written informed consent
* Affiliation with a social security scheme (excluding State Medical Aid
Specific criteria for genetic analyses:
* Participant has checked the boxes for participation in the genetic component.
Exclusion Criteria
* Medical management incompatible with the objectives of the study
* Patient who, in the doctor's opinion, is unlikely to comply with the study protocol
* Health conditions are incompatible with the sample collection required by the study
* Patient under legal protection (guardianship or trusteeship)
18 Years
ALL
No
Sponsors
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Institut Pasteur
INDUSTRY
Responsible Party
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Principal Investigators
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Patrick HOCHEDEZ, Dr
Role: PRINCIPAL_INVESTIGATOR
Institut Pasteur Medical Center
Locations
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Institut Pasteur Medical Center
Paris, , France
Countries
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Central Contacts
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Facility Contacts
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Patrick HOCHEDEZ, Dr
Role: primary
Other Identifiers
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2024-113
Identifier Type: -
Identifier Source: org_study_id