Inobrodib, Pomalidomide and Dexamethasone in Relapsed or Refractory Multiple Myeloma

NCT ID: NCT07096778

Last Updated: 2026-02-06

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: PHASE2
• Total Enrollment: 100 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2026-01-22
• Study Completion Date: 2029-12-01

Brief Summary

The purpose of this study is to learn more about the anti-cancer activity of inobrodib, when given in combination with pomalidomide and dexamethasone, in patients with multiple myeloma that has come back following treatment and which no longer responds to available therapies. The study treatment will not be compared to any other treatment and patients will know what treatment they are receiving. This study will also further explore the side effects of inobrodib in combination with these other medicines.

Detailed Description

This is a Phase II, open-label, multicenter study to evaluate the efficacy and safety of inobrodib in combination with pomalidomide and dexamethasone (InoPd) in patients with relapsed and refractory multiple myeloma (RRMM).

Patients must be 18 years or older and be refractory to least one proteosome inhibitor (PI), one anti-CD38 monoclonal antibody (mAb) and pomalidomide. Patients must also be previously treated with an approved bispecific T-cell engager [TCE].

Approximately 100 patients will be treated with 20 mg of inobrodib administered orally twice daily (b.i.d.) 4 days on / 3 days off for each 28-day cycle. Pomalidomide and dexamethasone will be administered as per standard of care (SoC), i.e., with a starting dose of 4 mg orally once daily on Day 1 to 21 of each 28-day cycle for pomalidomide, and 40 mg orally once daily on Days 1, 8, 15 and 22 for each 28-day cycle for dexamethasone. Study treatment should be continued until disease progression, initiation of new anticancer therapy, unacceptable toxicity or the patient meets any criteria for withdrawal from the study.

The primary objective is to assess the efficacy of InoPd in terms of objective response rate (ORR) based on International Myeloma Working Group (IMWG) criteria and assessed by Independent Review Committee (IRC).

Conditions

Multiple Myeloma Refractory; Multiple Myeloma in Relapse

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Inobrodib in combination with pomalidomide and dexamethasone

Group Type: EXPERIMENTAL

Inobrodib

Intervention Type: DRUG

20 mg orally twice daily (b.i.d.) 4 days on / 3 days off for each 28-day cycle.

Pomalidomide

Intervention Type: DRUG

4 mg orally once daily on Day 1 to 21 of each 28-day cycle

Dexamethasone

Intervention Type: DRUG

40 mg orally once daily on Days 1, 8, 15 and 22 for each 28-day cycle

Interventions

Inobrodib

20 mg orally twice daily (b.i.d.) 4 days on / 3 days off for each 28-day cycle.

Intervention Type: DRUG

Pomalidomide

4 mg orally once daily on Day 1 to 21 of each 28-day cycle

Intervention Type: DRUG

Dexamethasone

40 mg orally once daily on Days 1, 8, 15 and 22 for each 28-day cycle

Intervention Type: DRUG

Other Intervention Names

CS1477; Pomalyst; Imnovid

Eligibility Criteria

Inclusion Criteria

• Male or female ≥18 years of age
• Prior diagnosis of MM as defined according to IMWG criteria and relapsed or refractory to the last line of therapy
• Eastern Co-operative Oncology Group (ECOG) performance status of 0 to 2
• Adequate hematological, renal and hepatic function
• Willingness to use highly effective contraceptive measures (if sexually active) with all sexual partners

Exclusion Criteria

• Use of any investigational agent, chemotherapy, immunotherapy or anticancer agent from a previous clinical study within 14 days or 5 half-lives of first dose of study treatment, whichever is shortest; any antibody based therapy within 30 days
• Prior treatment with p300/CBP bromodomain inhibitors
• Known or suspected severe allergies to any active or inactive ingredients in the study medications (inobrodib, pomalidomide, dexamethasone) or any prior immunomodulatory drug (lenalidomide, thalidomide)
• Treatment with medicines or herbal supplements or foods (e.g. strong CYP3A4 inducers or inhibitors) that would interfere with treatment
• Major surgery within 4 weeks of the first dose of study treatment
• Live vaccine within 4 weeks of study treatment
• Active or unresolved adverse events
• Active malignancies (progressing or requiring change in treatment) in the last 24 months other than multiple myeloma
• Female patients who are pregnant or breast-feeding at any time during the study
• Any illness or medical history that would impact safety or compliance with study requirements or impact ability to interpret study data

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

CellCentric Ltd.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Naseer Qayum

Role: STUDY_DIRECTOR

CellCentric Ltd.

Locations

Royal Marsden NHS Foundation Trust

Sutton, London, United Kingdom

Site Status: RECRUITING

Imperial College Healthcare NHS Trust, Hammersmith Hospital

London, , United Kingdom

Site Status: RECRUITING

Countries

United Kingdom

Central Contacts

CS1477-04 Clinical Operations

Role: CONTACT

clinical@cellcentric.com

+44 1799 531130

Other Identifiers

1012518

Identifier Type: OTHER

Identifier Source: secondary_id

CCS1477-04

Identifier Type: -

Identifier Source: org_study_id