Relationship Between Complex Regional Pain Syndrome and Magnesium Depletion Score

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

117 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-01-01

Study Completion Date

2025-06-01

Brief Summary

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Complex Regional Pain Syndrome (CRPS) is a condition triggered by trauma such as surgery or a fracture. It is characterised by pain and limited mobility that are disproportionate to the severity of the trauma and the clinical course. Magnesium is recognised for its anti-inflammatory and antioxidant properties. The magnesium depletion score (MDS) is a more reliable and comprehensive scoring tool than measuring serum and urine magnesium levels. This score takes into account the patient's use of diuretics and proton pump inhibitors, their alcohol consumption, and their glomerular filtration rate. Impaired magnesium distribution may be a risk factor for CRPS development due to increased nociceptor activity. This study aimed to investigate whether an increased MDS score is a risk factor for CRPS development in individuals with traumatic limb injury.

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Detailed Description

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Conditions

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Complex Regional Pain Syndrome (CRPS)

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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traumatic extremity injury

scoring

Intervention Type OTHER

magnesium depletion score calculation

Interventions

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scoring

magnesium depletion score calculation

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Male and female patients aged 18-99 years with traumatic extremity injuries

Exclusion Criteria

* History of previous stroke, spinal cord injury
* Presence of radiculopathy, radicular pain in the affected extremity
* Previous surgery for cervical discopathy/lumbar discopathy
* Presence of oncological, haematological diseases
* History of previous peripheral nerve injury or previous surgery

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No