Whether Control of Serum Uric Acid (SUA) Improves Survival After Pancreatic Cancer

NCT ID: NCT07091526

Last Updated: 2025-12-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

168 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-07-29

Study Completion Date

2026-12-29

Brief Summary

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This retrospective study aims to analyze the impact of postoperative changes in serum uric acid (SUA) levels on the prognosis of patients undergoing pancreatic cancer resection.

Detailed Description

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Serum uric acid is a risk factor for gallbladder cancer in men and has a strong effect on pancreatic cancer in women. It has also been shown that elevated intracellular serum uric acid can induce an inflammatory stress response, which may promote its transformation, while elevated extracellular serum uric acidy further stimulate tumor cell proliferation, migration, and survival, and promote the development of highly aggressive cancer. In this study, the changes of serum uric acid before and after surgery was used as a prognostic marker for the survival of pancreatic cancer patients.

Conditions

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Serum Uric Acid

Keywords

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Serum uric acid Pancreatic cancer Pancreaticoduodenectomy Distal pancreatectomy

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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High serum uric acid

The increase of after serum uric acid operation compared with that before operation is≥10% Normal levels serum uric acid are typically 178 to 360 μm (3 to 6.8 mg/dl).

serum uric acid test

Intervention Type DIAGNOSTIC_TEST

Detect the serum uric acid in blood sample

Low serum uric acid

The increase of after serum uric acid operation compared with that before operation \< 10% Normal serum uric acid levels are typically 178 to 360 μm (3 to 6.8 mg/dl).

serum uric acid test

Intervention Type DIAGNOSTIC_TEST

Detect the serum uric acid in blood sample

Interventions

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serum uric acid test

Detect the serum uric acid in blood sample

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Patients with pathologically confirmed pancreatic cancer (primary)
* Patients who underwent Radical resection of pancreatic cancer(Pancreaticoduodenectomy or Distal pancreatectomy)
* The postoperative survival time was at least 6 weeks

Exclusion Criteria

* No surgery was performed, or only palliative surgery/ biopsy was performed
* Patients who underwent emergency hemodialysis or plasma exchange after surgery
* History of gout or long-term urate-lowering therapy, such as allopurinol
* Patients are missing follow-up data
* Hydrochlorothiazide and furosemide were used
* Chronic kidney disease
* Oncolytic syndrome
* Hemolytic anemia
* Lead poisoning
* Hyperparathyroidism
* Hypothyroidism
* A tyrosinase inhibitor was used
* Patients with nonpancreatic primary tumors
* Pregnant or postpartum women.
Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hepatopancreatobiliary Surgery Institute of Gansu Province

OTHER

Sponsor Role lead

Responsible Party

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Wenbo Meng

Director of Surgery

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Wenbo Meng, M.D. Ph. D.

Role: PRINCIPAL_INVESTIGATOR

Hepatopancreatobiliary Surgery Institute of Gansu Province

Locations

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Hepatopancreatobiliary Surgery Institute of Gansu Province

Lanzhou, Gansu, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Wenbo Meng, M.D. Ph. D.

Role: CONTACT

Phone: 13919177177

Email: [email protected]

Zhengping An, M.D.

Role: CONTACT

Phone: 18298415512

Email: [email protected]

Facility Contacts

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Wenbo Meng, MD,PhD

Role: primary

References

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Huang CF, Huang JJ, Mi NN, Lin YY, He QS, Lu YW, Yue P, Bai B, Zhang JD, Zhang C, Cai T, Fu WK, Gao L, Li X, Yuan JQ, Meng WB. Associations between serum uric acid and hepatobiliary-pancreatic cancer: A cohort study. World J Gastroenterol. 2020 Nov 28;26(44):7061-7075. doi: 10.3748/wjg.v26.i44.7061.

Reference Type BACKGROUND
PMID: 33311950 (View on PubMed)

Fini MA, Elias A, Johnson RJ, Wright RM. Contribution of uric acid to cancer risk, recurrence, and mortality. Clin Transl Med. 2012 Aug 15;1(1):16. doi: 10.1186/2001-1326-1-16.

Reference Type BACKGROUND
PMID: 23369448 (View on PubMed)

Other Identifiers

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SUA-PC

Identifier Type: -

Identifier Source: org_study_id