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Temporal Change in Parasternal Thickening Fraction as a Predictor for Weaning

NCT ID: NCT07083128

Last Updated: 2025-12-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

64 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-07-13

Study Completion Date

2026-03-05

Brief Summary

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optimal time to liberate from mechanical ventilation is highly prioritized since improper extubation time lead to serious consequences

Detailed Description

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Several parameters were proposed to assess proper weaning time including diaphragmatic ultrasound and extra-diaghragmatic muscles. previous research concluded an ability of parasternal intercostal (PIC) thickening to predict weaning outcomes. researchers of current study assumed that temporal changes in PIC thickening would provide greater ability to predict weaning outcomes

Conditions

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Mechanical Ventilation Weaning From Mechanical Ventilation Weaning Failure

Keywords

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Parasternal thickening; failed weaning; extubation

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Parasternal intercostal thickening

Temporal change in parasternal intercostal thickening fraction at initiation and 30 minutes of spontaneous breathing trial

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

\- Mechanically ventilated for 24 hours or more ready for weaning

Exclusion Criteria

* Refusal Tracheostomized Inability to obtain ultrasound views patients with neuromuscular disease
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Cairo University

OTHER

Sponsor Role lead

Responsible Party

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Mina Adolf Helmy

Lecturer of anesthesia and critical care

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Cairo University

Cairo, Cairo Governorate, Egypt

Site Status RECRUITING

Countries

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Egypt

Central Contacts

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Cairo University

Role: CONTACT

Phone: +201275716942

Email: [email protected]

Facility Contacts

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Cairo University

Role: primary

Mina Helmy

Role: backup

References

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Helmy MA, Hasanin A, Milad LM, Mostafa M, Hamimy WI, Muhareb RS, Raafat H. Ability of parasternal intercostal muscle thickening fraction to predict reintubation in surgical patients with sepsis. BMC Anesthesiol. 2024 Aug 22;24(1):294. doi: 10.1186/s12871-024-02666-8.

Reference Type RESULT
PMID: 39174907 (View on PubMed)

Helmy MA, Milad LM, Hasanin AM, Mostafa M, Mannaa AH, Youssef MM, Abdelaziz M, Alkonaiesy R, Elshal MM, Hosny O. Parasternal intercostal thickening at hospital admission: a promising indicator for mechanical ventilation risk in subjects with severe COVID-19. J Clin Monit Comput. 2023 Oct;37(5):1287-1293. doi: 10.1007/s10877-023-00989-4. Epub 2023 Mar 24.

Reference Type RESULT
PMID: 36961635 (View on PubMed)

Helmy MA, Hasanin A, Milad LM, Mostafa M, Fathy S. Parasternal intercostal muscle thickening as a predictor of non-invasive ventilation failure in patients with COVID-19. Anaesth Crit Care Pain Med. 2022 Jun;41(3):101063. doi: 10.1016/j.accpm.2022.101063. Epub 2022 Apr 26. No abstract available.

Reference Type RESULT
PMID: 35487407 (View on PubMed)

Helmy MA, Magdy Milad L, Osman SH, Ali MA, Hasanin A. Diaphragmatic excursion: A possible key player for predicting successful weaning in patients with severe COVID-19. Anaesth Crit Care Pain Med. 2021 Jun;40(3):100875. doi: 10.1016/j.accpm.2021.100875. Epub 2021 Apr 30. No abstract available.

Reference Type RESULT
PMID: 33940248 (View on PubMed)

Adolf Helmy M, Magdy Milad L, Hasanin A, Mostafa M. The novel use of diaphragmatic excursion on hospital admission to predict the need for ventilatory support in patients with coronavirus disease 2019. Anaesth Crit Care Pain Med. 2021 Dec;40(6):100976. doi: 10.1016/j.accpm.2021.100976. Epub 2021 Nov 5.

Reference Type RESULT
PMID: 34748940 (View on PubMed)

Other Identifiers

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Temporal change in PIC

Identifier Type: -

Identifier Source: org_study_id