New Saline-contrast EIT Method Without Breath Hold by Low Pass Filter

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

22 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-09-10

Study Completion Date

2024-10-15

Brief Summary

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The electrical impedance tomography (EIT) is a bedside, non-invasive, non-radiation imaging tool for lung mornitoring. Currently, the EIT saline-contrast method for lung perfusion evaluation has been widely used in clinical. However, this technique requires the patient to hold breath for 8-30s to avoid the respiratory interference. Hence, it is not suitable for patients that can not tolerate breath hold or unable to maintain a steady apnoea. This study aims to develop an algorithm system based on low frequency band pass filter for EIT saline-contrast lung perfusion estimation without ventilation interruption, and investigate the correlation and agreement of EIT results between the novel method and the conventional breath-hold method.

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Detailed Description

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Conditions

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Lung Diseases

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

SINGLE

Participants

Study Groups

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No apnea group

First, perform the EIT saline contrast method without apnea. After a 10-minute washout period, perform the conventional saline contrast method with apnea.

Group Type EXPERIMENTAL

Injection of hypertonic saline

Intervention Type OTHER

Injection 10 mL of 10% NaCl through central venous catheter

Apnea group

First, perform the conventional EIT saline contrast method with apnea. After a 10-minute washout period, perform the saline contrast method without apnea.

Group Type OTHER

Injection of hypertonic saline

Intervention Type OTHER

Injection 10 mL of 10% NaCl through central venous catheter

Interventions

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Injection of hypertonic saline

Injection 10 mL of 10% NaCl through central venous catheter

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* In need of lung perfusion assessment due to clinical condition
* With central venous catheter

Exclusion Criteria

* Pregnant or breastfeeding females
* contraindications to the use of EIT (automatic implantable cardioverter defibrillator, chest wounds limiting electrode belt placement, implantable pumps, etc.)
* severe hyperchloremia (\>155 mmol/L)
* unable to tolerate breath-hold maneuver
* edema disease (nephrotic syndrome, cirrhotic ascites, congestive heart failure, etc.)
* Patients with severe hypernatraemia or hyperchloremia and severe hypertonicity
* Hypertension (\>160/100 mmHg), hypokalaemia (\> 3.5 mmol/L)
* Acute renal failure in oliguric stage, chronic renal failure with reduced urine output and poor response to diuretics

Minimum Eligible Age

18 Years

Maximum Eligible Age

79 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No