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Brain Health Oneida

NCT ID: NCT07080866

Last Updated: 2025-12-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

19 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-09-02

Study Completion Date

2026-02-28

Brief Summary

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The purpose of this observational study is to better understand the relationship between stroke risk factors and brain MRI measures in the Native American population.

Participants will undergo:

* Carotid ultrasound
* Magnetic resonance imaging (MRI)
* Cognitive testing

Detailed Description

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Researchers' central hypothesis is that Native Americans (NAs) suffer from chronic psychological stress (PS) and inter-generational trauma related to historical loss (HL) which are manifested as inflammatory proteomic changes, leading to atherosclerotic vessel wall injury, stroke and vascular cognitive impairment (VCI). The researchers present a study to determine if MRI brain health metrics such as structural and functional connections, cerebral blood flow measures, brain morphometry are correlated with cardiovascular risk factors, atherosclerotic disease burden, blood inflammatory proteins, and scores on the Oneida cultural nutritional programs.

Conditions

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Oneida Nation Members

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Oneida Nation

Participants will be Native American and undergo MRI an ultrasound

MRI

Intervention Type DIAGNOSTIC_TEST

Participants will undergo a 60-minute MRI

Carotid ultrasound

Intervention Type DIAGNOSTIC_TEST

Participants will undergo an ultrasound

Interventions

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MRI

Participants will undergo a 60-minute MRI

Intervention Type DIAGNOSTIC_TEST

Carotid ultrasound

Participants will undergo an ultrasound

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Age 55-90
* Receiving healthcare though the Oneida Comprehensive Health Division

Exclusion Criteria

* Not Native American
* Contraindications to MRI scans
Minimum Eligible Age

55 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Wisconsin, Madison

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Robert Dempsey, MD

Role: PRINCIPAL_INVESTIGATOR

University of Wisconsin, Madison

Locations

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University of Wisconsin - Madison

Madison, Wisconsin, United States

Site Status

Oneida Nation Reservation

Oneida, Wisconsin, United States

Site Status

Countries

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United States

Other Identifiers

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2025-1005

Identifier Type: -

Identifier Source: org_study_id

A535700

Identifier Type: OTHER

Identifier Source: secondary_id

SMPH/NEURO SURG/NEURO SURG

Identifier Type: OTHER

Identifier Source: secondary_id

Protocol Version 9/22/2025

Identifier Type: OTHER

Identifier Source: secondary_id