Research on the Evolution, Geometry, and Alterations of the Periorbital Region Based on Age and Deformations

NCT ID: NCT07080320

Last Updated: 2026-01-16

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 60 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-09-16
• Study Completion Date: 2027-09-30

Brief Summary

The periorbital region of the face is a critical area affected by aging. Motion Capture (MoCap) allows the precise measurement of the mechanical properties of skin in this region. This study will validate MoCap as a tool for quantifying these properties, comparing it to traditional reference tools, and exploring how these properties evolve with age and external treatments. It will also assess MoCap's ability to detect the effects of various treatments such as tightening products and massages. Ultimately, this research will provide a deeper understanding of skin dynamics in the periorbital region and offer insights into both medical and cosmetic applications.

Conditions

Facial Skin; Motion Capture; Aging; Periorbital Region; Skin Movement; Vertical Jump

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: OTHER
• Blinding Strategy: NONE

Study Groups

subjects aged 18-33 years

Group Type: EXPERIMENTAL

MoCap

Intervention Type: DEVICE

For each subject, the displacement of markers, the deformation of regions between markers, and the evolution of angles formed by the markers during facial expressions and vertical movements will be analyzed with MoCap. These will be compared between the two age groups (18-33 years vs. 50-65 years) using a MANOVA model. The reference values for marker displacement will be defined by the interval between the 2.5% and 97.5% percentiles of the values for each marker. If the distribution is Gaussian, the percentiles will be derived from the standard normal distribution; otherwise, the non-parametric method will be used.

The intervention will be Interventions :

• Recruitment of healthy and pathological subjects.
• Full-face and macro images of the periorbital region
• Measurement of periorbital skin properties using MoCap and standard reference tools.
• Application of a tightening product (aloe vera) and periorbital massage.
• Measurement of skin response to a vertical jump.

subjects aged 50-65 years

Group Type: EXPERIMENTAL

MoCap

Intervention Type: DEVICE

For each subject, the displacement of markers, the deformation of regions between markers, and the evolution of angles formed by the markers during facial expressions and vertical movements will be analyzed with MoCap. These will be compared between the two age groups (18-33 years vs. 50-65 years) using a MANOVA model. The reference values for marker displacement will be defined by the interval between the 2.5% and 97.5% percentiles of the values for each marker. If the distribution is Gaussian, the percentiles will be derived from the standard normal distribution; otherwise, the non-parametric method will be used.

The intervention will be Interventions :

• Recruitment of healthy and pathological subjects.
• Full-face and macro images of the periorbital region
• Measurement of periorbital skin properties using MoCap and standard reference tools.
• Application of a tightening product (aloe vera) and periorbital massage.
• Measurement of skin response to a vertical jump.

Interventions

MoCap

For each subject, the displacement of markers, the deformation of regions between markers, and the evolution of angles formed by the markers during facial expressions and vertical movements will be analyzed with MoCap. These will be compared between the two age groups (18-33 years vs. 50-65 years) using a MANOVA model. The reference values for marker displacement will be defined by the interval between the 2.5% and 97.5% percentiles of the values for each marker. If the distribution is Gaussian, the percentiles will be derived from the standard normal distribution; otherwise, the non-parametric method will be used.

The intervention will be Interventions :

• Recruitment of healthy and pathological subjects.
• Full-face and macro images of the periorbital region
• Measurement of periorbital skin properties using MoCap and standard reference tools.
• Application of a tightening product (aloe vera) and periorbital massage.
• Measurement of skin response to a vertical jump.

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• Female participants
• Caucasian, Fitzpatrick skin types I-III
• BMI between 18.5 and 27, healthy participants
• Aged 18 to 65 years (inclusive)
• Not under guardianship or curatorship
• Informed written consent
• Social security affiliation
• Non-smokers for at least 5 years
• No excessive UV exposure (artificial or natural) in the last 3 weeks prior to the study or during the study

Exclusion Criteria

• Severe skin disorders preventing the application of electrodes or photo-reflective markers
• Neurovascular history affecting the face
• Ongoing treatments influencing facial tissues (e.g., corticosteroids)
• Current sleep disorders
• Psychiatric conditions or social interaction impairments
• Inner ear or balance disorders
• Osteoporosis, recent fractures, or fragile bone conditions
• Pregnant or breastfeeding women
• Under guardianship, curatorship, or legal protection

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Centre Hospitalier Universitaire, Amiens

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

CHRU Amiens

Amiens, , France

Site Status: RECRUITING

Countries

France

Central Contacts

Stéphanie Dakpé, Pr

Role: CONTACT

dakpe.stephanie@chu-amiens.fr

33+3 22 08 90 50

Other Identifiers

PI2025_843_0101

Identifier Type: -

Identifier Source: org_study_id