Pharmacokinetics of Petrelintide Following Administration to Participants With Impaired Renal Function

NCT ID: NCT07076030

Last Updated: 2026-01-15

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 39 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-04-15
• Study Completion Date: 2025-11-25

Brief Summary

This clinical research study is testing the study compound petrelintide that is being developed for the weight management in people with obesity or overweight with comorbidities or related diseases.

The aim of this clinical research study is to investigate whether the effects of petrelintide will be different in people with normal kidney function compared to people with impaired kidney function.

Detailed Description

This is a Phase 1, open-label, single-center, single dose, parallel-group, non-randomized study to evaluate the pharmacokinetics (PK), safety, and tolerability of petrelintide after a single dose in participants with mild, moderate, or severe renal impairment, and participants with normal renal function. Allocation of participants to the renal function groups will be based on the estimated glomerular filtration rate (eGFR).

Each participant will receive a single subcutaneous dose of petrelintide on Day 1.

Up to 24 participants with normal renal function and 24 participants with renal impairment (8 participants each in the following groups: mild, moderate, or severe renal impairment) will participate in this study.

Conditions

Renal Impairment

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

Group 1 Normal Renal Function

Each participant will receive a single subcutaneous dose of petrelintide on Day 1.

Group Type: EXPERIMENTAL

Petrelintide

Intervention Type: DRUG

Solution administered with a syringe

Group 2 Mild Renal Impairment

Each participant will receive a single subcutaneous dose of petrelintide on Day 1.

Group Type: EXPERIMENTAL

Petrelintide

Intervention Type: DRUG

Solution administered with a syringe

Group 3 Moderate Renal Impairment

Each participant will receive a single subcutaneous dose of petrelintide on Day 1.

Group Type: EXPERIMENTAL

Petrelintide

Intervention Type: DRUG

Solution administered with a syringe

Group 4 Severe Renal Impairment

Each participant will receive a single subcutaneous dose of petrelintide on Day 1.

Group Type: EXPERIMENTAL

Petrelintide

Intervention Type: DRUG

Solution administered with a syringe

Interventions

Petrelintide

Solution administered with a syringe

Intervention Type: DRUG

Other Intervention Names

ZP8396

Eligibility Criteria

Inclusion Criteria

1. Age: 18 to 65 years (both inclusive) at screening.

2. BMI (Body Mass Index): 21.0 to 40.0 kg/m2, inclusive, at screening.

3. Sex: Male and female participants.

4. Participants with mild, moderate, or severe renal impairment and participants with normal renal function.

5. For participants with renal impairment: stable renal impairment for 3 months prior to screening.

6. For participants with Type 2 diabetes mellitus and renal impairment:

1. HbA1c (hemoglobin A1c) ≤11% at screening.

2. On a stable diet and exercise regimen or stable metformin and/or SGLT2i (Sodium-Glucose Cotransporter 2 inhibitors) treatment for at least 3 months prior to screening.

Exclusion Criteria

1. Exposure to amylin analogs, including petrelintide (ZP8396) within the last 3 months.

2. Clinically significant acute illness within 4 weeks prior to Day 1, as judged by the Investigator to potentially interfere with the study conduct and/or results.

3. Impaired liver function, defined as alanine aminotransferase (ALT) >1.2 times upper normal limit, or bilirubin >1.2 times upper normal limit, measured at screening.

4. Presence or history of acute or chronic pancreatitis.

5. Known clinically significant gastric emptying abnormality (for example, severe gastroparesis, gastric outlet obstruction, gastric bypass operations, or sleeve gastrectomies) or chronic treatment that affects gastrointestinal motility.

6. Any disorder, unwillingness, or inability, not covered by any of the other exclusions criteria, which in the Investigator´s opinion, might jeopardize the participant´s safety or compliance with the protocol.

7. Participants with Type 1 diabetes mellitus as declared by the participant.

8. A history of additional risk factors for torsades de pointes (e.g., heart failure, hypokalemia, family history of Long QT Syndrome).

9. Presence or history of clinically significant arrhythmias or clinically significant conduction disorders.

10. A marked baseline prolongation of QT/QTc (e.g. repeated demonstration of a QTc interval >450 ms.

11. Smoking of more than 10 cigarettes (or equivalent nicotine consumption) per day.

Tobacco that contains menthol must not be consumed within 7 days prior to study drug administration.

12. Presence or history of following cardiovascular diseases:

1. Decompensated heart failure (New York Heart Association (NYHA) class III and IV).

2. Unstable angina pectoris.

3. Myocardial infarction within the last 12 months.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

ICON plc

INDUSTRY

Sponsor Role: collaborator

Zealand Pharma

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Victoria Kegel-Hübner, Dr.med.

Role: PRINCIPAL_INVESTIGATOR

Charité Research Organisation GmbH

Locations

Zealand Pharma

Søborg, Capital Region, Denmark

Countries

Denmark

Other Identifiers

ZP8396-24059

Identifier Type: -

Identifier Source: org_study_id