UG3 Pilot Clinical Trial

NCT ID: NCT07073898

Last Updated: 2025-11-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

65 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-09-26

Study Completion Date

2026-02-27

Brief Summary

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LungSMART Utah utilizes a Population Health Management (PHM) approach that addresses key barriers to Lung Cancer Screening (LCS) implementation by deploying a centralized Hub infrastructure for eligibility assessment, individualized risk assessment and Shared Decision Making (SDM), LCS referral, and screening completion assistance, thereby increasing LCS reach at scale among Community Health Centers (CHCs) patients across the state of Utah.

Detailed Description

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LungSMART Utah is a Sequential Multiple Assignment Randomized Trial (SMART) that promotes the reach of lung cancer screening (LCS) among patients who receive medical services at Utah Community Health Centers (CHCs). The study design consists of two sequential stages: an Eligibility Assessment phase to identify and engage individuals at risk to participate in a shared decision-making (SDM) session to assess LCS eligibility, recommendation, and preference, followed by an LCS Completion phase to promote follow-through with recommended screening.

In this pilot trial, 50 current or former tobacco users aged 50-80 who receive medical services at the Mountainlands CHC and have no recorded history of lung cancer and have not participated in a SDM about LCS will be identified for the study. In the Eligibility Assessment Phase, patients will be assessed for LCS eligibility through digital health interventions and, if eligible, will engage with a qualified registered nurse (RN) at a centralized "Hub" for a SDM session, with and be offered a referral for LCS if screening is recommended and preferred. Phase 1 interventions include repeated text messaging (TM+), conversational agent (CA), and educational video (VID) to engage patients in a SDM session. The LCS Completion phase evaluates telehealth interventions designed to address logistical barriers and hesitancy among referred patients in completing LCS. Interventions include CA and either proactive- or reactive-patient navigation (PN) to increase LCS completion among CHC patients. Clinic staff will also be queried to examine if further refinement of research workflow and procedures is needed. Mountainlands CHC has agreed to partner with us to recruit patient participants for this pilot study.

Conditions

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Lung Cancer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SEQUENTIAL

Primary Study Purpose

SCREENING

Blinding Strategy

NONE

Study Groups

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Repeated Text Messages (TM+)

Repeated text messages notifying patients that they may be eligible for Lung Cancer Screening (LCS).

Group Type OTHER

Repeated Text Messages (TM+)

Intervention Type OTHER

The text message notifies patients that they may be eligible for LCS and provides the patient with a connection to an registered nurse (RN) for LCS eligibility assessment and Shared Decision-Making (SDM) discussion. Response options include YES (to request that the HUB RN call the patient) or STOP (to opt out of any further messages).

Repeated Text Messages plus a Conversational Agent (TM+, CA)

Repeated text messages notifying patients that they may be eligible for LCS. In addition to text messages, patients will receive an automated, scripted, and interactive CA.

Group Type OTHER

Repeated Text Messages (TM+)

Intervention Type OTHER

The text message notifies patients that they may be eligible for LCS and provides the patient with a connection to an registered nurse (RN) for LCS eligibility assessment and Shared Decision-Making (SDM) discussion. Response options include YES (to request that the HUB RN call the patient) or STOP (to opt out of any further messages).

Conversational Agent (CA)

Intervention Type OTHER

The CA is designed to address specific hesitancy factors and barriers to Lung Cancer Screening (LCS). The CA uses a rule-based approach. CAs use a predefined conversation script with a fixed set of possible questions and responses to educate patients regarding the importance of LCS and engage them to be connected with RN for eligibility assessment and SDM.

Repeated Text Messages plus a Video (TM+, Video)

Repeated text messages notifying patients that they may be eligible for LCS. In addition to text messages, patients will receive an educational video sent directly to their cell phone.

Group Type OTHER

Repeated Text Messages (TM+)

Intervention Type OTHER

The text message notifies patients that they may be eligible for LCS and provides the patient with a connection to an registered nurse (RN) for LCS eligibility assessment and Shared Decision-Making (SDM) discussion. Response options include YES (to request that the HUB RN call the patient) or STOP (to opt out of any further messages).

Educational Video

Intervention Type OTHER

The educational video provides patients with information and answers commonly asked questions about LCS.

Repeated Text Messages plus a Conversational Agent and Video (TM+, CA, Video)

Repeated text messages notifying patients that they may be eligible for LCS. In addition to text messages, patients will receive an educational video sent directly to the patient's cell phone, along with a conversational agent to answer frequently asked LCS questions.

Additionally, patients will receive an educational video sent directly to the patient's cell phone and a chatbot to answer frequently asked LCS questions.

Group Type OTHER

Repeated Text Messages (TM+)

Intervention Type OTHER

The text message notifies patients that they may be eligible for LCS and provides the patient with a connection to an registered nurse (RN) for LCS eligibility assessment and Shared Decision-Making (SDM) discussion. Response options include YES (to request that the HUB RN call the patient) or STOP (to opt out of any further messages).

Conversational Agent (CA)

Intervention Type OTHER

The CA is designed to address specific hesitancy factors and barriers to Lung Cancer Screening (LCS). The CA uses a rule-based approach. CAs use a predefined conversation script with a fixed set of possible questions and responses to educate patients regarding the importance of LCS and engage them to be connected with RN for eligibility assessment and SDM.

Educational Video

Intervention Type OTHER

The educational video provides patients with information and answers commonly asked questions about LCS.

CA/PPN

A conversational agent to answer frequently asked LCS questions. In addition to proactive patient navigation.

Group Type OTHER

Conversational Agent (CA)

Intervention Type OTHER

The CA is designed to address specific hesitancy factors and barriers to Lung Cancer Screening (LCS). The CA uses a rule-based approach. CAs use a predefined conversation script with a fixed set of possible questions and responses to educate patients regarding the importance of LCS and engage them to be connected with RN for eligibility assessment and SDM.

Proactive Patient Navigation (PPN)

Intervention Type OTHER

Proactive patient navigation enables trained navigators to actively identify and reach out to patients who may need assistance completing LCS, rather than waiting for patients to seek help on their own.

CA/RPN

A conversational agent to answer frequently asked LCS questions. In addition to reactive patient navigation.

Group Type OTHER

Conversational Agent (CA)

Intervention Type OTHER

The CA is designed to address specific hesitancy factors and barriers to Lung Cancer Screening (LCS). The CA uses a rule-based approach. CAs use a predefined conversation script with a fixed set of possible questions and responses to educate patients regarding the importance of LCS and engage them to be connected with RN for eligibility assessment and SDM.

Reactive Patient Navigation (RPN)

Intervention Type OTHER

Reactive patient navigation makes trained navigators available to those who seek assistance in completing LCS.

Interventions

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Repeated Text Messages (TM+)

The text message notifies patients that they may be eligible for LCS and provides the patient with a connection to an registered nurse (RN) for LCS eligibility assessment and Shared Decision-Making (SDM) discussion. Response options include YES (to request that the HUB RN call the patient) or STOP (to opt out of any further messages).

Intervention Type OTHER

Conversational Agent (CA)

The CA is designed to address specific hesitancy factors and barriers to Lung Cancer Screening (LCS). The CA uses a rule-based approach. CAs use a predefined conversation script with a fixed set of possible questions and responses to educate patients regarding the importance of LCS and engage them to be connected with RN for eligibility assessment and SDM.

Intervention Type OTHER

Educational Video

The educational video provides patients with information and answers commonly asked questions about LCS.

Intervention Type OTHER

Proactive Patient Navigation (PPN)

Proactive patient navigation enables trained navigators to actively identify and reach out to patients who may need assistance completing LCS, rather than waiting for patients to seek help on their own.

Intervention Type OTHER

Reactive Patient Navigation (RPN)

Reactive patient navigation makes trained navigators available to those who seek assistance in completing LCS.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Is currently a patient at Mountainlands CHCs
* Speak English or Spanish
* Current or former male or female smokers
* Age 50-80
* Have a phone that can receive text messages
* Electronic health records indicate they have not opted out of receiving text contact from the clinic

Exclusion Criteria

* Persons with lung cancer or previous SDM
Minimum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Cancer Institute (NCI)

NIH

Sponsor Role collaborator

University of Utah

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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David Wetter, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Huntsman Cancer Institute/ University of Utah

Locations

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Huntsman Cancer Institute/ University of Utah

Salt Lake City, Utah, United States

Site Status

Countries

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United States

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Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

UG3CA287109-02

Identifier Type: NIH

Identifier Source: secondary_id

View Link

HCI177308

Identifier Type: -

Identifier Source: org_study_id

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