Web-based Alcohol-specific Inhibition Training in Adolescents and Young Adults With Alcohol Use Disorder

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

210 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-07-23

Study Completion Date

2026-03-31

Brief Summary

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Alcohol misuse is one of the most common risk factors for health problems and premature death among adolescents and young adults worldwide. Although there are effective treatments for alcohol use disorder (AUD), there is still a need to further improve their effectiveness and make them easier to access. Early research suggests that alcohol-specific inhibition training, when used in addition to specialized treatment, can improve treatment outcomes. This training aims to strengthen inhibition specifically in situations related to alcohol. The goal of this project is to offer this training for the first time in the form of a smartphone app, which is expected to increase the availability of the training. The main aim of the study is to evaluate whether this new app-based cognitive training is feasible as an add-on to the treatment of AUD in adolescents and young adults. In addition, the study will gather initial insights into whether the training affects drinking behavior and related brain processes. The project will be conducted as a double-blind, clinical pilot study. A total of 210 adolescents and young adults between 14 and 27 years old will be recruited from five specialized treatment centers. After the first study visit, participants will be randomly assigned to one of two groups: (1) an intervention group receiving the alcohol-specific inhibition training or (2) a control group receiving a similar alcohol-nonspecific inhibition training. During their participation, all participants will complete six short training sessions with the app. About one month later, they will complete six additional booster training sessions. This research may help develop effective, easily accessible tools to support young people with alcohol use disorder.

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Detailed Description

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Conditions

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Alcohol Use Disorder (AUD)

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

TRIPLE

Participants Caregivers Outcome Assessors

Study Groups

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Alcohol-specific inhibition training

12 sessions of alcohol-specific inhibition training

Group Type EXPERIMENTAL

Alcohol-specific inhibition training

Intervention Type OTHER

Twelve sessions of alcohol-specific inhibition training

Control training

12 sessions of unspecific inhibition training

Group Type ACTIVE_COMPARATOR

Control training

Intervention Type OTHER

Twelve sessions of unspecific inhibition training

Interventions

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Alcohol-specific inhibition training

Twelve sessions of alcohol-specific inhibition training

Intervention Type OTHER

Control training

Twelve sessions of unspecific inhibition training

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age 14 - 27 years
* Alcohol use disorder identification test (AUDIT) ≥ 8
* Alcohol use disorder scale (AUD-S) ≥ 2
* Currently undergoing outpatient treatment or online counselling in one of 5 specialized treatment settings
* Sufficient German language skills
* Informed Consent as documented by signature
* Owner of a smartphone with internet access

Exclusion Criteria

* Other severe substance use (except nicotine and cannabis) determined by the cut-off value ≥ 25 in the drug use disorder identification test (DUDIT)
* Current medical conditions excluding participation
* Inability to read and understand the participant's information
* Enrolment of the investigator, his/her family members, employees, and other dependent persons

* Current medication affecting EEG (e.g., benzodiazepines)
* Other severe substance use determined by the cut-off value ≥ 25 in the DUDIT (except nicotine)
* History of epilepsy

Minimum Eligible Age

14 Years

Maximum Eligible Age

27 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No