Monitoring Oedema in Heart Failure to Improve Function and Reduce Hospitalisation Risk

NCT ID: NCT07067658

Last Updated: 2025-12-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

300 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-12-18

Study Completion Date

2027-07-31

Brief Summary

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This study will evaluate the Heartfelt device, a novel, passive monitoring system that detects early signs of fluid build-up in patients (oedema) with heart failure by measuring changes in foot and lower leg volume through capture of 3D images. The trial will assess whether this device, when added to standard NHS care, improves quality of life and reduces heart failure-related events compared to standard care alone.

Detailed Description

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Heart failure often causes fluid build-up in the legs and lungs, leading to symptoms like swelling and breathlessness. Spotting these signs early is important to help prevent worsening health and hospital admissions. While patients are encouraged to monitor their weight and symptoms, this can be hard to keep up with.

The study will involve 300 participants from at least 15 NHS hospitals and GP practices across the UK. People will be randomly placed into one of two groups: one will receive standard NHS care (including regular weight checks and symptom monitoring), and the other will receive the same care plus the Heartfelt device. The trial is partly blinded: participants may see technical messages (e.g. if the device goes offline), but only the group using the device will trigger clinical alerts.

The Heartfelt device takes daily images of the feet to track changes in size, without the need for any extra effort from the user. If important changes are spotted, alerts are sent to the clinical team so they can act quickly.

The study will look at quality of life, how often the device sends useful data, healthcare use, and how teams respond to alerts. It will also explore how easy the device is to use and whether it offers good value for money.

Patients will help shape the study to make sure the findings are relevant and useful for future care.

Conditions

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Heart Failure

Keywords

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Peripheral Oedema Heart Failure Decomposition Heart Failure Hospitalization

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

This 12-month study involves up to 300 patients using the Heartfelt device at home.
Primary Study Purpose

PREVENTION

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors
Both participants and care providers will be blinded, thus will not know whether patients are in the control or intervention arm.

Study Groups

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Enhanced Standard Care + Heartfelt Device

Heartfelt device's camera-based system passively measures foot and leg swelling each day as participants walk past it. Patients in this experimental control arm will not receive health alerts from the Heartfelt device, though data will still be passively collected.

Patients will also be provided with the British Heart Foundation patient booklet to improve their understanding and self-monitoring of the disease.

Group Type EXPERIMENTAL

Installation of Heartfelt Device

Intervention Type DEVICE

Device installed in the patient's home and capturing foot volume data which are processed in the cloud.

Enhanced Standard care

Intervention Type OTHER

Patients with heart failure are advised to weigh daily and to report weight increase to their clinician. They should also report changes in breathlessness, tiredness and other symptoms associated with heart failure decompensation. At the start of the study, they will be reminded (or told) about the importance of self-checks and will be handed a patient booklet (from the British Heart Foundation) to standardise patients' knowledge.

Questionnaires

Intervention Type OTHER

Patients are presented with one or more optional questionnaires (some validated, some bespoke)

Heartfelt device alerting system

Intervention Type DEVICE

The Heartfelt device sends alerts on the active comparator arm to the patients directly (audio-visual alert on the device, and app alerts), carers and/or medical professionals.

Enhanced Standard Care (Control)

In addition to standard care activities, participants have the Heartfelt device at home. During this arm, data is captured without sending health alerts or measurement data to the patient, carers and clinicians.

Patients will also be provided with the British Heart Foundation patient booklet to improve their understanding and self-monitoring of the disease.

Group Type ACTIVE_COMPARATOR

Installation of Heartfelt Device

Intervention Type DEVICE

Device installed in the patient's home and capturing foot volume data which are processed in the cloud.

Enhanced Standard care

Intervention Type OTHER

Patients with heart failure are advised to weigh daily and to report weight increase to their clinician. They should also report changes in breathlessness, tiredness and other symptoms associated with heart failure decompensation. At the start of the study, they will be reminded (or told) about the importance of self-checks and will be handed a patient booklet (from the British Heart Foundation) to standardise patients' knowledge.

Questionnaires

Intervention Type OTHER

Patients are presented with one or more optional questionnaires (some validated, some bespoke)

Interventions

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Installation of Heartfelt Device

Device installed in the patient's home and capturing foot volume data which are processed in the cloud.

Intervention Type DEVICE

Enhanced Standard care

Patients with heart failure are advised to weigh daily and to report weight increase to their clinician. They should also report changes in breathlessness, tiredness and other symptoms associated with heart failure decompensation. At the start of the study, they will be reminded (or told) about the importance of self-checks and will be handed a patient booklet (from the British Heart Foundation) to standardise patients' knowledge.

Intervention Type OTHER

Questionnaires

Patients are presented with one or more optional questionnaires (some validated, some bespoke)

Intervention Type OTHER

Heartfelt device alerting system

The Heartfelt device sends alerts on the active comparator arm to the patients directly (audio-visual alert on the device, and app alerts), carers and/or medical professionals.

Intervention Type DEVICE

Other Intervention Names

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Remote Patient Monitoring Device Daily Weighing Breathlessness Dizziness Tiredness 5Q-5D Bespoke Questionnaires Remote patient monitoring device

Eligibility Criteria

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Inclusion Criteria

* Adults \>18 years
* Diagnosis of heart failure (any aetiology or left ventricular ejection fraction classification), any timeframe
* Currently prescribed ≥40 mg/day of furosemide (or equivalent loop diuretic) for at least one month.
* Heart failure hospital admission and moderate or severe leg oedema in the previous 12 months.
* Lives in the UK, with a home environment suitable for installation of the Heartfelt device.

Exclusion Criteria

* Amputation of both feet
* Bed-bound for more than 20h per 24h period
* Bandages to lower limbs every day
* Regular wheelchair user inside their home
* No fixed abode
* Participation in another interventional trial that may interfere with endpoints
* Life expectancy \<6 months, in the opinion of the investigator
* Inability to provide informed consent due to cognitive impairment
* Language barriers that preclude understanding of trial procedures (unless translation resources are available in relevant language)
* Inability to install the device (even with assistance) allowing at least 6 months of data capture by the end of the study.
* Patients with severe aortic stenosis or awaiting a heart procedure or surgery
* Patient with end stage renal disease (eGFR \<20)
* Pregnancy or lack of contraceptive measures if of child-bearing potential
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Manchester University NHS Foundation Trust

OTHER_GOV

Sponsor Role collaborator

University of Glasgow

OTHER

Sponsor Role collaborator

Heartfelt Technologies

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Croydon Health Services NHS Trust

Croydon, Greater London, United Kingdom

Site Status RECRUITING

Countries

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United Kingdom

Facility Contacts

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Baldeep Sidhu, MD

Role: primary

Other Identifiers

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HFT-2025-1

Identifier Type: -

Identifier Source: org_study_id