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A Study to Compare the Combination of BMS-986504 With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP Deletion

NCT ID: NCT07063745

Last Updated: 2025-11-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE2/PHASE3

Total Enrollment

590 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-11-28

Study Completion Date

2031-08-12

Brief Summary

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The purpose of this study is to compare the clinical benefit of the combination of BMS-986504 (a selective MTA-cooperative inhibitor of PRMT5) plus pembrolizumab and chemotherapy versus placebo plus pembrolizumab and chemotherapy in first-line metastatic non-small cell lung cancer participants with homozygous MTAP deletion

Detailed Description

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Conditions

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Metastatic Non-small Cell Lung Cancer With MTAP Deletion

Keywords

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PRMT5 Lung cancer NSCLC MTAP CDKN2A MRTX1719 First-line

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors
The Phase 2 portion of this study will be blinded to sites, participants, investigators, and certain site-facing members of the Sponsor.

The Phase 3 portion of this study will be blinded to participants, investigators, and the Sponsor.

Study Groups

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Arm A: BMS-986504 + Pembrolizumab + Chemotherapy

Group Type ACTIVE_COMPARATOR

BMS-986504

Intervention Type DRUG

Specified dose on specified days

Pembrolizumab

Intervention Type DRUG

Specified dose on specified days

Cisplatin

Intervention Type DRUG

Specified dose on specified days

Carboplatin

Intervention Type DRUG

Specified dose on specified days

Pemetrexed

Intervention Type DRUG

Specified dose on specified days

Paclitaxel

Intervention Type DRUG

Specified dose on specified days

Nab-paclitaxel

Intervention Type DRUG

Specified dose on specified days

Arm B: BMS-986504 + Pembrolizumab + Chemotherapy

Group Type ACTIVE_COMPARATOR

BMS-986504

Intervention Type DRUG

Specified dose on specified days

Pembrolizumab

Intervention Type DRUG

Specified dose on specified days

Cisplatin

Intervention Type DRUG

Specified dose on specified days

Carboplatin

Intervention Type DRUG

Specified dose on specified days

Pemetrexed

Intervention Type DRUG

Specified dose on specified days

Paclitaxel

Intervention Type DRUG

Specified dose on specified days

Nab-paclitaxel

Intervention Type DRUG

Specified dose on specified days

Arm C: Placebo + Pembrolizumab + Chemotherapy

Group Type PLACEBO_COMPARATOR

Pembrolizumab

Intervention Type DRUG

Specified dose on specified days

Placebo

Intervention Type OTHER

Specified dose on specified days

Cisplatin

Intervention Type DRUG

Specified dose on specified days

Carboplatin

Intervention Type DRUG

Specified dose on specified days

Pemetrexed

Intervention Type DRUG

Specified dose on specified days

Paclitaxel

Intervention Type DRUG

Specified dose on specified days

Nab-paclitaxel

Intervention Type DRUG

Specified dose on specified days

Arm D: Placebo + Pembrolizumab + Chemotherapy

Group Type PLACEBO_COMPARATOR

Pembrolizumab

Intervention Type DRUG

Specified dose on specified days

Placebo

Intervention Type OTHER

Specified dose on specified days

Cisplatin

Intervention Type DRUG

Specified dose on specified days

Carboplatin

Intervention Type DRUG

Specified dose on specified days

Pemetrexed

Intervention Type DRUG

Specified dose on specified days

Paclitaxel

Intervention Type DRUG

Specified dose on specified days

Nab-paclitaxel

Intervention Type DRUG

Specified dose on specified days

Arm E: BMS-986504 + Pembrolizumab + Chemotherapy

Group Type ACTIVE_COMPARATOR

BMS-986504

Intervention Type DRUG

Specified dose on specified days

Pembrolizumab

Intervention Type DRUG

Specified dose on specified days

Cisplatin

Intervention Type DRUG

Specified dose on specified days

Carboplatin

Intervention Type DRUG

Specified dose on specified days

Pemetrexed

Intervention Type DRUG

Specified dose on specified days

Paclitaxel

Intervention Type DRUG

Specified dose on specified days

Nab-paclitaxel

Intervention Type DRUG

Specified dose on specified days

Arm F: Placebo + Pembrolizumab + Chemotherapy

Group Type PLACEBO_COMPARATOR

Pembrolizumab

Intervention Type DRUG

Specified dose on specified days

Placebo

Intervention Type OTHER

Specified dose on specified days

Cisplatin

Intervention Type DRUG

Specified dose on specified days

Carboplatin

Intervention Type DRUG

Specified dose on specified days

Pemetrexed

Intervention Type DRUG

Specified dose on specified days

Paclitaxel

Intervention Type DRUG

Specified dose on specified days

Nab-paclitaxel

Intervention Type DRUG

Specified dose on specified days

Interventions

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BMS-986504

Specified dose on specified days

Intervention Type DRUG

Pembrolizumab

Specified dose on specified days

Intervention Type DRUG

Placebo

Specified dose on specified days

Intervention Type OTHER

Cisplatin

Specified dose on specified days

Intervention Type DRUG

Carboplatin

Specified dose on specified days

Intervention Type DRUG

Pemetrexed

Specified dose on specified days

Intervention Type DRUG

Paclitaxel

Specified dose on specified days

Intervention Type DRUG

Nab-paclitaxel

Specified dose on specified days

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Participants must have Metastatic (Stage IV or recurrent) non-small cell lung cancer (NSCLC) (as defined by the American Joint Committee on Cancer, Ninth Edition) with no prior systemic anti-cancer therapy for metastatic disease.
* Participants must have histologically confirmed diagnosis of NSCLC and homozygous methylthioadenosine phosphorylase (MTAP) deletion or MTAP loss.
* Participants must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.
* Participants must have at least 1 measurable lesion as per RECIST v1.1.

Exclusion Criteria

* Nonsquamous participants must not have documented targetable oncogenic mutation or actionable genetic alterations (AGAs) for which there is a standard of care (SoC) available as first-line (1L) therapy.
* Participants must not have symptomatic brain metastases or spinal cord compression.
* Participants must not have any prior systemic therapy (chemotherapy, immunotherapy, targeted therapy, or biological therapy) for metastatic non-small cell lung cancer (mNSCLC). Note: One cycle of SoC treatment prior to randomization will be allowed for participants who require immediate treatment if clinically indicated.
* Participants must not have any known or suspected impairment of gastrointestinal function that may prohibit the ability to absorb or swallow an oral medication without chewing or crushing.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Bristol-Myers Squibb

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bristol-Myers Squibb

Role: STUDY_DIRECTOR

Bristol-Myers Squibb

Locations

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Alaska Oncology and Hematology

Anchorage, Alaska, United States

Site Status RECRUITING

Local Institution - 0388

Phoenix, Arizona, United States

Site Status NOT_YET_RECRUITING

Local Institution - 0120

Tucson, Arizona, United States

Site Status NOT_YET_RECRUITING

Highlands Oncology Group

Springdale, Arkansas, United States

Site Status RECRUITING

Local Institution - 0407

Los Angeles, California, United States

Site Status NOT_YET_RECRUITING

Local Institution - 0444

Los Angeles, California, United States

Site Status NOT_YET_RECRUITING

Local Institution - 0152

Fort Lauderdale, Florida, United States

Site Status NOT_YET_RECRUITING

Local Institution - 0389

Jacksonville, Florida, United States

Site Status NOT_YET_RECRUITING

Local Institution - 0430

St. Petersburg, Florida, United States

Site Status WITHDRAWN

St. Luke's Cancer Institute: Boise

Boise, Idaho, United States

Site Status RECRUITING

Local Institution - 0333

Lexington, Kentucky, United States

Site Status NOT_YET_RECRUITING

Local Institution - 0125

Lexington, Kentucky, United States

Site Status NOT_YET_RECRUITING

Local Institution - 0127

Scarborough, Maine, United States

Site Status NOT_YET_RECRUITING

Local Institution - 0158

Boston, Massachusetts, United States

Site Status NOT_YET_RECRUITING

Local Institution - 0418

Ann Arbor, Michigan, United States

Site Status NOT_YET_RECRUITING

Local Institution - 0405

Detroit, Michigan, United States

Site Status NOT_YET_RECRUITING

Local Institution - 0420

Traverse City, Michigan, United States

Site Status NOT_YET_RECRUITING

Local Institution - 0182

Rochester, Minnesota, United States

Site Status NOT_YET_RECRUITING

Oncology Hematology West P.C. dba Nebraska Cancer Specialists

Omaha, Nebraska, United States

Site Status RECRUITING

Local Institution - 0179

Hawthorne, New York, United States

Site Status NOT_YET_RECRUITING

Local Institution - 0128

Rochester, New York, United States

Site Status NOT_YET_RECRUITING

Local Institution - 0163

Cleveland, Ohio, United States

Site Status NOT_YET_RECRUITING

Local Institution - 0129

Columbus, Ohio, United States

Site Status NOT_YET_RECRUITING

Local Institution - 0164

Portland, Oregon, United States

Site Status NOT_YET_RECRUITING

Local Institution - 0348

Portland, Oregon, United States

Site Status NOT_YET_RECRUITING

Local Institution - 0433

Dallas, Texas, United States

Site Status NOT_YET_RECRUITING

Local Institution - 0374

El Paso, Texas, United States

Site Status NOT_YET_RECRUITING

Local Institution - 0132

Houston, Texas, United States

Site Status NOT_YET_RECRUITING

Local Institution - 0377

The Woodlands, Texas, United States

Site Status WITHDRAWN

Local Institution - 0354

Salt Lake City, Utah, United States

Site Status NOT_YET_RECRUITING

Local Institution - 0131

Fairfax, Virginia, United States

Site Status WITHDRAWN

Local Institution - 0186

Richmond, Virginia, United States

Site Status NOT_YET_RECRUITING

Local Institution - 0145

Seattle, Washington, United States

Site Status NOT_YET_RECRUITING

Local Institution - 0463

Rosario, Santa Fe Province, Argentina

Site Status NOT_YET_RECRUITING

Local Institution - 0447

Buenos Aires, , Argentina

Site Status NOT_YET_RECRUITING

Local Institution - 0446

Buenos Aires, , Argentina

Site Status NOT_YET_RECRUITING

Local Institution - 0432

Liverpool, New South Wales, Australia

Site Status NOT_YET_RECRUITING

Local Institution - 0382

Birtinya, Queensland, Australia

Site Status NOT_YET_RECRUITING

Local Institution - 0381

Elizabeth Vale, South Australia, Australia

Site Status NOT_YET_RECRUITING

Local Institution - 0431

Hobart, Tasmania, Australia

Site Status NOT_YET_RECRUITING

Local Institution - 0367

Ballarat Central, Victoria, Australia

Site Status NOT_YET_RECRUITING

Local Institution - 0368

Garran, , Australia

Site Status NOT_YET_RECRUITING

Local Institution - 0373

Woolloongabba, , Australia

Site Status NOT_YET_RECRUITING

Local Institution - 0207

Vienna, , Austria

Site Status NOT_YET_RECRUITING

Local Institution - 0227

Edegem, Antwerpen, Belgium

Site Status NOT_YET_RECRUITING

Local Institution - 0226

Hasselt, Limburg, Belgium

Site Status NOT_YET_RECRUITING

Local Institution - 0225

Yvoir, Namur, Belgium

Site Status NOT_YET_RECRUITING

Local Institution - 0277

Roeselare, West-Vlaanderen, Belgium

Site Status NOT_YET_RECRUITING

Local Institution - 0342

Brussels, , Belgium

Site Status NOT_YET_RECRUITING

Local Institution - 0340

Liège, , Belgium

Site Status NOT_YET_RECRUITING

Local Institution - 0088

Vitória, Espírito Santo, Brazil

Site Status NOT_YET_RECRUITING

Local Institution - 0079

Natal, Rio Grande do Norte, Brazil

Site Status NOT_YET_RECRUITING

Local Institution - 0346

Porto Alegre, Rio Grande do Sul, Brazil

Site Status NOT_YET_RECRUITING

Local Institution - 0085

Blumenau, Santa Catarina, Brazil

Site Status NOT_YET_RECRUITING

Local Institution - 0081

Barretos, São Paulo, Brazil

Site Status NOT_YET_RECRUITING

Local Institution - 0076

Bauru, São Paulo, Brazil

Site Status NOT_YET_RECRUITING

Local Institution - 0094

Campinas, São Paulo, Brazil

Site Status NOT_YET_RECRUITING

Local Institution - 0355

São Caetano do Sul, São Paulo, Brazil

Site Status NOT_YET_RECRUITING

Local Institution - 0351

São José do Rio Preto, São Paulo, Brazil

Site Status NOT_YET_RECRUITING

Local Institution - 0095

São Paulo, São Paulo, Brazil

Site Status NOT_YET_RECRUITING

Local Institution - 0091

Rio de Janeiro, , Brazil

Site Status NOT_YET_RECRUITING

Local Institution - 0078

São Paulo, , Brazil

Site Status NOT_YET_RECRUITING

Local Institution - 0315

Panagyurishte, Pazardzhik, Bulgaria

Site Status NOT_YET_RECRUITING

Local Institution - 0459

Sofia, Sofia, Bulgaria

Site Status NOT_YET_RECRUITING

Local Institution - 0309

Haskovo, , Bulgaria

Site Status NOT_YET_RECRUITING

Local Institution - 0308

Rousse, , Bulgaria

Site Status NOT_YET_RECRUITING

Local Institution - 0460

Sofia, , Bulgaria

Site Status NOT_YET_RECRUITING

Local Institution - 0307

Stara Zagora, , Bulgaria

Site Status NOT_YET_RECRUITING

Local Institution - 0072

Hefei, Anhui, China

Site Status NOT_YET_RECRUITING

Local Institution - 0074

Beijing, Beijing Municipality, China

Site Status NOT_YET_RECRUITING

Local Institution - 0049

Beijing, Beijing Municipality, China

Site Status NOT_YET_RECRUITING

Local Institution - 0286

Beijing, Beijing Municipality, China

Site Status NOT_YET_RECRUITING

Local Institution - 0046

Fuzhou, Fujian, China

Site Status NOT_YET_RECRUITING

Local Institution - 0100

Xiamen, Fujian, China

Site Status NOT_YET_RECRUITING

Local Institution - 0099

Guangzhou, Guangdong, China

Site Status NOT_YET_RECRUITING

Local Institution - 0443

Guangzhou, Guangdong, China

Site Status NOT_YET_RECRUITING

Local Institution - 0061

Guangzhou, Guangdong, China

Site Status NOT_YET_RECRUITING

Local Institution - 0281

Shenzhen, Guangdong, China

Site Status NOT_YET_RECRUITING

Local Institution - 0067

Nanning, Guangxi, China

Site Status NOT_YET_RECRUITING

Local Institution - 0408

Guiyang, Guizhou, China

Site Status NOT_YET_RECRUITING

Local Institution - 0353

Shijiazhuang, Hebei, China

Site Status NOT_YET_RECRUITING

Local Institution - 0106

Harbin, Heilongjiang, China

Site Status NOT_YET_RECRUITING

Local Institution - 0107

Zhengzhou, Henan, China

Site Status NOT_YET_RECRUITING

Local Institution - 0048

Wuhan, Hubei, China

Site Status NOT_YET_RECRUITING

Local Institution - 0059

Wuhan, Hubei, China

Site Status NOT_YET_RECRUITING

Local Institution - 0387

Changsha, Hunan, China

Site Status NOT_YET_RECRUITING

Local Institution - 0050

Changsha, Hunan, China

Site Status NOT_YET_RECRUITING

Local Institution - 0352

Nanjing, Jiangsu, China

Site Status NOT_YET_RECRUITING

Local Institution - 0279

Nanjing, Jiangsu, China

Site Status NOT_YET_RECRUITING

Local Institution - 0110

Nanchang, Jiangxi, China

Site Status NOT_YET_RECRUITING

Local Institution - 0284

Shenyang, Liaoning, China

Site Status NOT_YET_RECRUITING

Local Institution - 0104

Shenyang, Liaoning, China

Site Status NOT_YET_RECRUITING

Local Institution - 0103

Shenyang, Liaoning, China

Site Status NOT_YET_RECRUITING

Local Institution - 0060

Xi'an, Shaanxi, China

Site Status NOT_YET_RECRUITING

Local Institution - 0051

Jinan, Shandong, China

Site Status NOT_YET_RECRUITING

Local Institution - 0066

Linyi, Shandong, China

Site Status NOT_YET_RECRUITING

Local Institution - 0068

Qingdao, Shandong, China

Site Status NOT_YET_RECRUITING

Local Institution - 0278

Shanghai, Shanghai Municipality, China

Site Status NOT_YET_RECRUITING

Local Institution - 0343

Shanghai, Shanghai Municipality, China

Site Status NOT_YET_RECRUITING

Local Institution - 0283

Taiyuan, Shanxi, China

Site Status NOT_YET_RECRUITING

Local Institution - 0102

Chengdu, Sichuan, China

Site Status NOT_YET_RECRUITING

Local Institution - 0109

Chengdu, Sichuan, China

Site Status NOT_YET_RECRUITING

Local Institution - 0280

Hangzhou, Zhejiang, China

Site Status NOT_YET_RECRUITING

Local Institution - 0069

Hangzhou, Zhejiang, China

Site Status NOT_YET_RECRUITING

Local Institution - 0054

Hangzhou, Zhejiang, China

Site Status NOT_YET_RECRUITING

Local Institution - 0386

Nanjing, , China

Site Status NOT_YET_RECRUITING

Local Institution - 0047

Zhengzhou, , China

Site Status NOT_YET_RECRUITING

Local Institution - 0330

Medellín, Antioquia, Colombia

Site Status NOT_YET_RECRUITING

Local Institution - 0305

Bogotá, Cundinamarca, Colombia

Site Status NOT_YET_RECRUITING

Local Institution - 0306

Montería, Departamento de Córdoba, Colombia

Site Status NOT_YET_RECRUITING

Local Institution - 0251

Hradec Králové, Hradec Králové, Czechia

Site Status NOT_YET_RECRUITING

Local Institution - 0250

Olomouc, , Czechia

Site Status NOT_YET_RECRUITING

Local Institution - 0356

Copenhagen, Capital Region, Denmark

Site Status NOT_YET_RECRUITING

Local Institution - 0219

Pessac, Aquitaine, France

Site Status NOT_YET_RECRUITING

Local Institution - 0217

Caen, Calvados, France

Site Status NOT_YET_RECRUITING

Local Institution - 0212

Dijon, Côte-d'Or, France

Site Status NOT_YET_RECRUITING

Local Institution - 0341

Besançon, Doubs, France

Site Status NOT_YET_RECRUITING

Local Institution - 0221

Brest, Finistère, France

Site Status NOT_YET_RECRUITING

Local Institution - 0216

Toulouse, Haute-Garonne, France

Site Status NOT_YET_RECRUITING

Local Institution - 0220

Montpellier, Hérault, France

Site Status NOT_YET_RECRUITING

Local Institution - 0222

Rennes, Ille-et-Vilaine, France

Site Status NOT_YET_RECRUITING

Local Institution - 0215

Saint-Herblain, Loire-Atlantique, France

Site Status NOT_YET_RECRUITING

Local Institution - 0211

Vandœuvre-lès-Nancy, Meurthe-et-Moselle, France

Site Status NOT_YET_RECRUITING

Local Institution - 0224

Marseille, Provence-Alpes-Côte d'Azur Region, France

Site Status NOT_YET_RECRUITING

Local Institution - 0223

Clermont-Ferrand, Puy-de-Dôme, France

Site Status NOT_YET_RECRUITING

Local Institution - 0214

Pierre-Bénite, Rhône, France

Site Status NOT_YET_RECRUITING

Local Institution - 0213

Créteil, Val-de-Marne, France

Site Status NOT_YET_RECRUITING

Local Institution - 0429

Paris, , France

Site Status NOT_YET_RECRUITING

Local Institution - 0218

Paris, , France

Site Status NOT_YET_RECRUITING

Local Institution - 0338

Tours, , France

Site Status NOT_YET_RECRUITING

Local Institution - 0202

München, Bavaria, Germany

Site Status NOT_YET_RECRUITING

Local Institution - 0209

Regensburg, Bavaria, Germany

Site Status NOT_YET_RECRUITING

Local Institution - 0008

Pátrai, Achaḯa, Greece

Site Status NOT_YET_RECRUITING

Local Institution - 0005

Athens, Attikí, Greece

Site Status NOT_YET_RECRUITING

Local Institution - 0001

Athens, Attikí, Greece

Site Status NOT_YET_RECRUITING

Local Institution - 0009

Athens, Attikí, Greece

Site Status NOT_YET_RECRUITING

Local Institution - 0006

Thessaloniki, Kentrikí Makedonía, Greece

Site Status NOT_YET_RECRUITING

Local Institution - 0003

Larissa, Thessalía, Greece

Site Status NOT_YET_RECRUITING

Local Institution - 0285

Hksar, , Hong Kong

Site Status NOT_YET_RECRUITING

Local Institution - 0323

Shatin, , Hong Kong

Site Status NOT_YET_RECRUITING

Local Institution - 0290

Gyula, Bekes County, Hungary

Site Status NOT_YET_RECRUITING

Local Institution - 0291

Gyöngyös, Heves County, Hungary

Site Status NOT_YET_RECRUITING

Local Institution - 0287

Farkasgyepű, Veszprém megye, Hungary

Site Status NOT_YET_RECRUITING

Local Institution - 0288

Budapest, , Hungary

Site Status NOT_YET_RECRUITING

Local Institution - 0263

Bangalore, Karnataka, India

Site Status NOT_YET_RECRUITING

Local Institution - 0344

Bengaluru, Karnataka, India

Site Status NOT_YET_RECRUITING

Local Institution - 0345

Mumbai, Maharashtra, India

Site Status NOT_YET_RECRUITING

Local Institution - 0266

Mumbai, Maharashtra, India

Site Status NOT_YET_RECRUITING

Local Institution - 0267

New Delhi, National Capital Territory of Delhi, India

Site Status NOT_YET_RECRUITING

Local Institution - 0265

Hyderabad, Telangana, India

Site Status NOT_YET_RECRUITING

Local Institution - 0264

Varanasi, Uttar Pradesh, India

Site Status NOT_YET_RECRUITING

Local Institution - 0010

Kfar Saba, Central District, Israel

Site Status NOT_YET_RECRUITING

Local Institution - 0011

Ramat Gan, Central District, Israel

Site Status NOT_YET_RECRUITING

Local Institution - 0017

Jerusalem, Jerusalem, Israel

Site Status NOT_YET_RECRUITING

Local Institution - 0013

Jerusalem, Jerusalem, Israel

Site Status NOT_YET_RECRUITING

Local Institution - 0016

Afula, Northern District, Israel

Site Status NOT_YET_RECRUITING

Local Institution - 0014

Haifa, Northern District, Israel

Site Status NOT_YET_RECRUITING

Local Institution - 0105

Napoli, Campania, Italy

Site Status NOT_YET_RECRUITING

Local Institution - 0042

Aviano, Friuli Venezia Giulia, Italy

Site Status NOT_YET_RECRUITING

Local Institution - 0037

Orbassano, Torino, Italy

Site Status NOT_YET_RECRUITING

Local Institution - 0044

Perugia, Umbria, Italy

Site Status NOT_YET_RECRUITING

Local Institution - 0098

Bologna, , Italy

Site Status NOT_YET_RECRUITING

Local Institution - 0039

Milan, , Italy

Site Status NOT_YET_RECRUITING

Local Institution - 0045

Milan, , Italy

Site Status NOT_YET_RECRUITING

Local Institution - 0035

Ravenna, , Italy

Site Status NOT_YET_RECRUITING

Local Institution - 0243

Nagoya, Aichi-ken, Japan

Site Status NOT_YET_RECRUITING

Local Institution - 0236

Kashiwa, Chiba, Japan

Site Status NOT_YET_RECRUITING

Local Institution - 0334

Otashi, Gunma, Japan

Site Status NOT_YET_RECRUITING

Local Institution - 0233

Sapporo, Hokkaido, Japan

Site Status NOT_YET_RECRUITING

Local Institution - 0336

Himeji, Hyōgo, Japan

Site Status NOT_YET_RECRUITING

Local Institution - 0247

Kobe, Hyōgo, Japan

Site Status NOT_YET_RECRUITING

Local Institution - 0335

Shiwa-gun Yahaba-cho, Iwate, Japan

Site Status NOT_YET_RECRUITING

Local Institution - 0257

Kawasaki, Kanagawa, Japan

Site Status NOT_YET_RECRUITING

Local Institution - 0238

Yokohama, Kanagawa, Japan

Site Status NOT_YET_RECRUITING

Local Institution - 0241

Nankoku, Kochi, Japan

Site Status NOT_YET_RECRUITING

Local Institution - 0237

Matsusaka, Mie-ken, Japan

Site Status NOT_YET_RECRUITING

Local Institution - 0232

Sendai, Miyagi, Japan

Site Status NOT_YET_RECRUITING

Local Institution - 0240

Hirakata, Osaka, Japan

Site Status NOT_YET_RECRUITING

Local Institution - 0245

Hidaka, Saitama, Japan

Site Status NOT_YET_RECRUITING

Local Institution - 0235

Shimotsuga, Tochigi, Japan

Site Status NOT_YET_RECRUITING

Local Institution - 0234

Bunkyo-ku, Tokyo, Japan

Site Status NOT_YET_RECRUITING

Local Institution - 0242

Ube, Yamaguchi, Japan

Site Status NOT_YET_RECRUITING

Local Institution - 0246

Fukuoka, , Japan

Site Status NOT_YET_RECRUITING

Local Institution - 0244

Okayama, , Japan

Site Status NOT_YET_RECRUITING

Local Institution - 0239

Osaka, , Japan

Site Status NOT_YET_RECRUITING

Local Institution - 0413

Kuala Lumpur, Kuala Lumpur, Malaysia

Site Status NOT_YET_RECRUITING

Local Institution - 0390

Kuching, Sarawak, Malaysia

Site Status NOT_YET_RECRUITING

Local Institution - 0296

Guadalajara, Jalisco, Mexico

Site Status NOT_YET_RECRUITING

Local Institution - 0326

Guadalajara, Jalisco, Mexico

Site Status NOT_YET_RECRUITING

Local Institution - 0293

Mexico City, Mexico City, Mexico

Site Status NOT_YET_RECRUITING

Local Institution - 0294

Mexico City, Mexico City, Mexico

Site Status WITHDRAWN

Local Institution - 0298

Monterrey, Nuevo León, Mexico

Site Status NOT_YET_RECRUITING

Local Institution - 0297

Oaxaca City, Oaxaca, Mexico

Site Status NOT_YET_RECRUITING

Local Institution - 0328

Querétaro City, Querétaro, Mexico

Site Status NOT_YET_RECRUITING

Local Institution - 0327

Chihuahua City, , Mexico

Site Status NOT_YET_RECRUITING

Local Institution - 0331

Puebla City, , Mexico

Site Status NOT_YET_RECRUITING

Local Institution - 0445

Veldhoven, North Brabant, Netherlands

Site Status NOT_YET_RECRUITING

Local Institution - 0230

Arnhem, , Netherlands

Site Status WITHDRAWN

Local Institution - 0249

Groningen, , Netherlands

Site Status NOT_YET_RECRUITING

Local Institution - 0096

Drammen, Buskerud, Norway

Site Status NOT_YET_RECRUITING

Local Institution - 0262

Poznan, Greater Poland Voivodeship, Poland

Site Status NOT_YET_RECRUITING

Local Institution - 0259

Krakow, Lesser Poland Voivodeship, Poland

Site Status NOT_YET_RECRUITING

Local Institution - 0261

Warsaw, Masovian Voivodeship, Poland

Site Status NOT_YET_RECRUITING

Local Institution - 0458

Wieliszew, Masovian Voivodeship, Poland

Site Status NOT_YET_RECRUITING

Local Institution - 0258

Prabuty, Pomeranian Voivodeship, Poland

Site Status NOT_YET_RECRUITING

Local Institution - 0260

Bydgoszcz, , Poland

Site Status NOT_YET_RECRUITING

Local Institution - 0021

Bucharest, București, Romania

Site Status NOT_YET_RECRUITING

Local Institution - 0019

Florești, Cluj, Romania

Site Status NOT_YET_RECRUITING

Local Institution - 0025

Craiova, Dolj, Romania

Site Status NOT_YET_RECRUITING

Local Institution - 0027

Otopeni, Ilfov, Romania

Site Status NOT_YET_RECRUITING

Local Institution - 0020

Bucharest, , Romania

Site Status NOT_YET_RECRUITING

Local Institution - 0022

Cluj-Napoca, , Romania

Site Status NOT_YET_RECRUITING

Local Institution - 0023

Cluj-Napoca, , Romania

Site Status NOT_YET_RECRUITING

Local Institution - 0031

Iași, , Romania

Site Status NOT_YET_RECRUITING

Local Institution - 0026

Iași, , Romania

Site Status NOT_YET_RECRUITING

Local Institution - 0030

Ploieşti, , Romania

Site Status NOT_YET_RECRUITING

Local Institution - 0272

Cheongju-si, Chungcheongbuk-do [Chungbuk], South Korea

Site Status NOT_YET_RECRUITING

Local Institution - 0271

Goyang-si, Kyǒnggi-do, South Korea

Site Status NOT_YET_RECRUITING

Local Institution - 0273

Seongnam, Kyǒnggi-do, South Korea

Site Status NOT_YET_RECRUITING

Local Institution - 0270

Seoul, Seoul-teukbyeolsi [Seoul], South Korea

Site Status NOT_YET_RECRUITING

Local Institution - 0269

Seoul, Seoul-teukbyeolsi [Seoul], South Korea

Site Status NOT_YET_RECRUITING

Local Institution - 0268

Seoul, Seoul-teukbyeolsi [Seoul], South Korea

Site Status NOT_YET_RECRUITING

Local Institution - 0274

Seoul, Seoul-teukbyeolsi [Seoul], South Korea

Site Status NOT_YET_RECRUITING

Local Institution - 0116

Barcelona, Barcelona [Barcelona], Spain

Site Status NOT_YET_RECRUITING

Local Institution - 0248

Hospitalet, Barcelona [Barcelona], Spain

Site Status NOT_YET_RECRUITING

Local Institution - 0253

Barcelona, Catalunya [Cataluña], Spain

Site Status WITHDRAWN

Local Institution - 0118

Madrid, Madrid, Comunidad de, Spain

Site Status NOT_YET_RECRUITING

Local Institution - 0254

Madrid, Madrid, Comunidad de, Spain

Site Status NOT_YET_RECRUITING

Local Institution - 0252

Majadahonda, Madrid, Comunidad de, Spain

Site Status NOT_YET_RECRUITING

Local Institution - 0117

Málaga, , Spain

Site Status NOT_YET_RECRUITING

Local Institution - 0256

Seville, , Spain

Site Status NOT_YET_RECRUITING

Local Institution - 0255

Valencia, , Spain

Site Status NOT_YET_RECRUITING

Chi Mei Medical Center Liouying Branch

Tainan, Tainan, Taiwan

Site Status RECRUITING

Local Institution - 0111

Tainan, , Taiwan

Site Status NOT_YET_RECRUITING

Local Institution - 0113

Taipei, , Taiwan

Site Status NOT_YET_RECRUITING

Taipei Medical University Hospital

Taipei, , Taiwan

Site Status RECRUITING

Local Institution - 0112

Taoyuan District, , Taiwan

Site Status NOT_YET_RECRUITING

Local Institution - 0411

Bangkok, , Thailand

Site Status NOT_YET_RECRUITING

Local Institution - 0412

Bangkok, , Thailand

Site Status NOT_YET_RECRUITING

Local Institution - 0349

Izmir, Karsiyaka, İzmir, Turkey (Türkiye)

Site Status NOT_YET_RECRUITING

Local Institution - 0318

Adana, , Turkey (Türkiye)

Site Status NOT_YET_RECRUITING

Local Institution - 0317

Adana, , Turkey (Türkiye)

Site Status NOT_YET_RECRUITING

Local Institution - 0321

Ankara, , Turkey (Türkiye)

Site Status NOT_YET_RECRUITING

Local Institution - 0350

Antalya, , Turkey (Türkiye)

Site Status NOT_YET_RECRUITING

Local Institution - 0320

Bursa, , Turkey (Türkiye)

Site Status NOT_YET_RECRUITING

Local Institution - 0319

Edirne, , Turkey (Türkiye)

Site Status NOT_YET_RECRUITING

Local Institution - 0228

London, London, City of, United Kingdom

Site Status NOT_YET_RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

United States Argentina Australia Austria Belgium Brazil Bulgaria China Colombia Czechia Denmark France Germany Greece Hong Kong Hungary India Israel Italy Japan Malaysia Mexico Netherlands Norway Poland Romania South Korea Spain Taiwan Thailand Turkey (Türkiye) United Kingdom

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

BMS Clinical Trials Contact Center www.BMSClinicalTrials.com

Role: CONTACT

Phone: 8559073286

Email: [email protected]

First line of the email MUST contain the NCT# and Site#

Role: CONTACT

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Steven Liu, Site 0119

Role: primary

Site 0388

Role: primary

Site 0120

Role: primary

Eric Schaefer, Site 0135

Role: primary

Site 0407

Role: primary

Site 0444

Role: primary

Site 0152

Role: primary

Site 0389

Role: primary

Peyman Haghighat, Site 0124

Role: primary

Site 0333

Role: primary

Site 0125

Role: primary

Site 0127

Role: primary

Site 0158

Role: primary

Site 0418

Role: primary

Site 0405

Role: primary

Site 0420

Role: primary

Site 0182

Role: primary

Geetha Palaniappan, Site 0160

Role: primary

Site 0179

Role: primary

Site 0128

Role: primary

Site 0163

Role: primary

Site 0129

Role: primary

Site 0164

Role: primary

Site 0348

Role: primary

Site 0433

Role: primary

Site 0374

Role: primary

Site 0132

Role: primary

Site 0354

Role: primary

Site 0186

Role: primary

Site 0145

Role: primary

Site 0463

Role: primary

Site 0447

Role: primary

Site 0446

Role: primary

Site 0432

Role: primary

Site 0382

Role: primary

Site 0381

Role: primary

Site 0431

Role: primary

Site 0367

Role: primary

Site 0368

Role: primary

Site 0373

Role: primary

Site 0207

Role: primary

Site 0227

Role: primary

Site 0226

Role: primary

Site 0225

Role: primary

Site 0277

Role: primary

Site 0342

Role: primary

Site 0340

Role: primary

Site 0088

Role: primary

Site 0079

Role: primary

Site 0346

Role: primary

Site 0085

Role: primary

Site 0081

Role: primary

Site 0076

Role: primary

Site 0094

Role: primary

Site 0355

Role: primary

Site 0351

Role: primary

Site 0095

Role: primary

Site 0091

Role: primary

Site 0078

Role: primary

Site 0315

Role: primary

Site 0459

Role: primary

Site 0309

Role: primary

Site 0308

Role: primary

Site 0460

Role: primary

Site 0307

Role: primary

Site 0072

Role: primary

Site 0074

Role: primary

Site 0049

Role: primary

Site 0286

Role: primary

Site 0046

Role: primary

Site 0100

Role: primary

Site 0099

Role: primary

Site 0443

Role: primary

Site 0061

Role: primary

Site 0281

Role: primary

Site 0067

Role: primary

Site 0408

Role: primary

Site 0353

Role: primary

Site 0106

Role: primary

Site 0107

Role: primary

Site 0048

Role: primary

Site 0059

Role: primary

Site 0387

Role: primary

Site 0050

Role: primary

Site 0352

Role: primary

Site 0279

Role: primary

Site 0110

Role: primary

Site 0284

Role: primary

Site 0104

Role: primary

Site 0103

Role: primary

Site 0060

Role: primary

Site 0051

Role: primary

Site 0066

Role: primary

Site 0068

Role: primary

Site 0278

Role: primary

Site 0343

Role: primary

Site 0283

Role: primary

Site 0102

Role: primary

Site 0109

Role: primary

Site 0280

Role: primary

Site 0069

Role: primary

Site 0054

Role: primary

Site 0386

Role: primary

Site 0047

Role: primary

Site 0330

Role: primary

Site 0305

Role: primary

Site 0306

Role: primary

Site 0251

Role: primary

Site 0250

Role: primary

Site 0356

Role: primary

Site 0219

Role: primary

Site 0217

Role: primary

Site 0212

Role: primary

Site 0341

Role: primary

Site 0221

Role: primary

Site 0216

Role: primary

Site 0220

Role: primary

Site 0222

Role: primary

Site 0215

Role: primary

Site 0211

Role: primary

Site 0224

Role: primary

Site 0223

Role: primary

Site 0214

Role: primary

Site 0213

Role: primary

Site 0429

Role: primary

Site 0218

Role: primary

Site 0338

Role: primary

Site 0202

Role: primary

Site 0209

Role: primary

Site 0008

Role: primary

Site 0005

Role: primary

Site 0001

Role: primary

Site 0009

Role: primary

Site 0006

Role: primary

Site 0003

Role: primary

Site 0285

Role: primary

Site 0323

Role: primary

Site 0290

Role: primary

Site 0291

Role: primary

Site 0287

Role: primary

Site 0288

Role: primary

Site 0263

Role: primary

Site 0344

Role: primary

Site 0345

Role: primary

Site 0266

Role: primary

Site 0267

Role: primary

Site 0265

Role: primary

Site 0264

Role: primary

Site 0010

Role: primary

Site 0011

Role: primary

Site 0017

Role: primary

Site 0013

Role: primary

Site 0016

Role: primary

Site 0014

Role: primary

Site 0105

Role: primary

Site 0042

Role: primary

Site 0037

Role: primary

Site 0044

Role: primary

Site 0098

Role: primary

Site 0039

Role: primary

Site 0045

Role: primary

Site 0035

Role: primary

Site 0243

Role: primary

Site 0236

Role: primary

Site 0334

Role: primary

Site 0233

Role: primary

Site 0336

Role: primary

Site 0247

Role: primary

Site 0335

Role: primary

Site 0257

Role: primary

Site 0238

Role: primary

Site 0241

Role: primary

Site 0237

Role: primary

Site 0232

Role: primary

Site 0240

Role: primary

Site 0245

Role: primary

Site 0235

Role: primary

Site 0234

Role: primary

Site 0242

Role: primary

Site 0246

Role: primary

Site 0244

Role: primary

Site 0239

Role: primary

Site 0413

Role: primary

Site 0390

Role: primary

Site 0296

Role: primary

Site 0326

Role: primary

Site 0293

Role: primary

Site 0298

Role: primary

Site 0297

Role: primary

Site 0328

Role: primary

Site 0327

Role: primary

Site 0331

Role: primary

Site 0445

Role: primary

Site 0249

Role: primary

Site 0096

Role: primary

Site 0262

Role: primary

Site 0259

Role: primary

Site 0261

Role: primary

Site 0458

Role: primary

Site 0258

Role: primary

Site 0260

Role: primary

Site 0021

Role: primary

Site 0019

Role: primary

Site 0025

Role: primary

Site 0027

Role: primary

Site 0020

Role: primary

Site 0022

Role: primary

Site 0023

Role: primary

Site 0031

Role: primary

Site 0026

Role: primary

Site 0030

Role: primary

Site 0272

Role: primary

Site 0271

Role: primary

Site 0273

Role: primary

Site 0270

Role: primary

Site 0269

Role: primary

Site 0268

Role: primary

Site 0274

Role: primary

Site 0116

Role: primary

Site 0248

Role: primary

Site 0118

Role: primary

Site 0254

Role: primary

Site 0252

Role: primary

Site 0117

Role: primary

Site 0256

Role: primary

Site 0255

Role: primary

Cheng-Yao Lin, Site 0114

Role: primary

Site 0111

Role: primary

Site 0113

Role: primary

Chao-Hua Chiu, Site 0115

Role: primary

Site 0112

Role: primary

Site 0411

Role: primary

Site 0412

Role: primary

Site 0349

Role: primary

Site 0318

Role: primary

Site 0317

Role: primary

Site 0321

Role: primary

Site 0350

Role: primary

Site 0320

Role: primary

Site 0319

Role: primary

Site 0228

Role: primary

Related Links

Access external resources that provide additional context or updates about the study.

https://www.bms.com/researchers-and-partners/clinical-trials-and-research.html

BMS Clinical Trial Information

https://www.bmsclinicaltrials.com/us/en/clinical-trials/NCT07063745.html

BMS Clinical Trial Patient Recruiting

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

2025-521511-40

Identifier Type: OTHER

Identifier Source: secondary_id

U1111-1319-8383

Identifier Type: OTHER

Identifier Source: secondary_id

CA2400029

Identifier Type: OTHER

Identifier Source: secondary_id

CA240-0029

Identifier Type: -

Identifier Source: org_study_id