Comparing Augmented Reality and Virtual Reality Glasses to Help Children Feel Less Pain and Anxiety During Local Anesthesia

NCT ID: NCT07060170

Last Updated: 2025-07-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-12-01

Study Completion Date

2025-08-30

Brief Summary

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The goal of this clinical trial is to learn if audio-visual method of distraction is useful to control the pain and fear associated with dental treatment in children. The main questions it aims to answer are:

• How their body reacts-such as changes in heart rate, oxygen levels, and certain chemicals in their saliva-before and after getting local anesthesia? Researchers will test two types of glasses that display cartoons to help children feel less anxious.

Participants will:

* Have an introductory visit to be more familiar with dental environment and their cooperation will be tested.
* In the next 2 visits they will wear either of the glasses while receiving local anesthesia
* Saliva will be collected, and their heart rate and oxygen levels will be calculated each time

Detailed Description

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Conditions

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Dental Anxiety Dental Fear Dental Fear and Anxiety

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Teeth in each patient will be randomly assigned to receive both interventions sequentially, using a simple randomization technique. Each time a new patient is to be enrolled in the study, he\\she will be asked to select a sequentially numbered sealed opaque envelop that determines which type of distraction method will be implemented first. In the subsequent treatment visit, the other distraction technique will be automatically applied, since this is a split mouth designed study.

A set of 40 envelopes (20 envelopes for augmented reality glasses and 20 envelops for virtual reality glasses) will be kept with a third party (the main supervisor), who will not be involved in the data collection, to ensure allocation concealment.
Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

SINGLE

Outcome Assessors
The main supervisor will code the patients' tooth allocation in order to blind the statistician and the clinical pathologist who will assess the salivary biomarker levels in the samples.

Study Groups

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Maxillary right primary molars

In this Split-mouth Randomized Controlled Trial, 5-8-year-old female and male children will be enrolled. They will receive local anesthesia on the right side of the arch using one of the distraction methods, then after one to two weeks they will receive local anesthesia on other side of the arch using a different distraction method

Group Type ACTIVE_COMPARATOR

Augmented Reality Glasses

Intervention Type DEVICE

The child will wear the augmented reality glass, and a cartoon movie will be displayed during the injection of local anesthesia

Virtual Reality Glasses

Intervention Type DEVICE

The child will wear the glass, and a cartoon movie will be displayed during the injection of local anesthesia.

Maxillary left primary molars

In this Split-mouth Randomized Controlled Trial, 5-8-year-old female and male children will be enrolled. They will receive local anesthesia on the left side of the arch using one of the distraction methods, then after one to two weeks they will receive local anesthesia on other side of the arch using a different distraction method

Group Type ACTIVE_COMPARATOR

Augmented Reality Glasses

Intervention Type DEVICE

The child will wear the augmented reality glass, and a cartoon movie will be displayed during the injection of local anesthesia

Virtual Reality Glasses

Intervention Type DEVICE

The child will wear the glass, and a cartoon movie will be displayed during the injection of local anesthesia.

Interventions

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Augmented Reality Glasses

The child will wear the augmented reality glass, and a cartoon movie will be displayed during the injection of local anesthesia

Intervention Type DEVICE

Virtual Reality Glasses

The child will wear the glass, and a cartoon movie will be displayed during the injection of local anesthesia.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. 5-8 year-old female and male patients.
2. Cooperative patients (rating 3 or 4 on the Frankl's Behavior Rating Scale).
3. American Society of Anesthesiologists (ASA) Class (I).
4. Patients need dental treatment under local anesthetic infiltration.
5. Patients without known anxiety disorders.
6. Patients with body weight that is considered normal according to their age and gender (95th percentile growth curve).
7. Patients without a prior history of receiving local anesthetic.
8. Patients with at least one vital primary molar with deep carious lesion on each side of the dental arch, who require to be treated under local anesthesia

Exclusion Criteria

1. Patients with special health care needs.
2. Patients on corticosteroid medications.
3. Patients having known salivary disorders, such as Sjogren's syndrome.
4. Parents who refused to sign the informed consent.
Minimum Eligible Age

5 Years

Maximum Eligible Age

8 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Riham Abbas

OTHER

Sponsor Role lead

Responsible Party

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Riham Abbas

General practitioner

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Professor of Pediatric Dentistry and Dental Public Health

Role: STUDY_DIRECTOR

Faculty of Dentistry, Ain Shams University

Lecturer of Pediatric Dentistry and Dental Public Health

Role: STUDY_DIRECTOR

Faculty of Dentistry, Ain Shams University

Locations

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Pediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Ain Shams University, Cairo, Egypt

Cairo, Egypt, Egypt

Site Status RECRUITING

Countries

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Egypt

Central Contacts

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Master's Degree Candidate

Role: CONTACT

1554566997 ext. +20

Riham A Abbas, Master's degree Candidate

Role: CONTACT

Facility Contacts

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Professor of Pediatric Dentistry and Dental Public Health

Role: primary

1006506028 ext. +20

Master's Degree Candidate

Role: backup

1554566997 ext. +20

References

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Singh Y, Parameshwarappa P, Mathew MG, Meghana SB, Kenchappa M, Nagaveni NB. Comparison of distraction techniques using salivary biomarkers during local anaesthesia administration in children aged 3-5 years: A clinical study. Indian J Dent Res. 2023 Apr-Jun;34(2):169-173. doi: 10.4103/ijdr.ijdr_132_22.

Reference Type BACKGROUND
PMID: 37787206 (View on PubMed)

Subramaniam SD, Doss B, Chanderasekar LD, Madhavan A, Rosary AM. Scope of physiological and behavioural pain assessment techniques in children - a review. Healthc Technol Lett. 2018 Jul 17;5(4):124-129. doi: 10.1049/htl.2017.0108. eCollection 2018 Aug.

Reference Type BACKGROUND
PMID: 30155264 (View on PubMed)

Sharma Y, Bhatia HP, Sood S, Sharma N, Singh A. Effectiveness of Virtual Reality Glasses Digital Screens and Verbal Command as a Method to Distract Young Patients during Administration of Local Anesthesia. Int J Clin Pediatr Dent. 2021;14(Suppl 2):S143-S147. doi: 10.5005/jp-journals-10005-2094.

Reference Type BACKGROUND
PMID: 35645477 (View on PubMed)

Rao DG, Havale R, Nagaraj M, Karobari NM, Latha AM, Tharay N, Shrutha SP. Assessment of Efficacy of Virtual Reality Distraction in Reducing Pain Perception and Anxiety in Children Aged 6-10 Years: A Behavioral Interventional Study. Int J Clin Pediatr Dent. 2019 Nov-Dec;12(6):510-513. doi: 10.5005/jp-journals-10005-1694.

Reference Type BACKGROUND
PMID: 32440065 (View on PubMed)

Asl Aminabadi N, Erfanparast L, Sohrabi A, Ghertasi Oskouei S, Naghili A. The Impact of Virtual Reality Distraction on Pain and Anxiety during Dental Treatment in 4-6 Year-Old Children: a Randomized Controlled Clinical Trial. J Dent Res Dent Clin Dent Prospects. 2012 Fall;6(4):117-24. doi: 10.5681/joddd.2012.025. Epub 2012 Nov 12.

Reference Type BACKGROUND
PMID: 23277857 (View on PubMed)

Other Identifiers

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FDASU-Rec IM012411

Identifier Type: -

Identifier Source: org_study_id

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