Phase I/II Clinical Study of HRS-1738 for the Diagnosis of Prostate Cancer Patients

NCT ID: NCT07056439

Last Updated: 2025-07-09

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: PHASE1/PHASE2
• Total Enrollment: 50 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-07-31
• Study Completion Date: 2026-08-31

Brief Summary

This study aims to evaluate the safety and pharmacokinetics of HRS-1738 injection in adult patients with prostate cancer.

Conditions

PET Imaging in Patients With Prostate Cancer

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: DIAGNOSTIC
• Blinding Strategy: NONE

Study Groups

HRS-1738 Group

Group Type: EXPERIMENTAL

HRS-1738 Injection

Intervention Type: DRUG

HRS-1738 injection.

Interventions

HRS-1738 Injection

HRS-1738 injection.

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Be able to understand and abide by the procedures and requirements of this study and voluntarily sign the informed consent form.

2. Male, aged ≥18 years old.

3. ECOG (Eastern Oncology Collaboration) Physical Condition score: 0 or 1.

4. Prostate adenocarcinoma confirmed by histopathology.

5. The distance between enrollment and the most recent surgical treatment should be at least 12 weeks. If the patient has recovered from the surgery before enrollment and meets other enrollment criteria, it can be relaxed to 8 weeks as determined by the investigator.

6. The functions of the major organs should meet the requirements.

7. For male subjects, they need to agree to take effective contraceptive measures with their partners within one week after the last administration of the investigational drug from the date of signing the informed consent form, and have no plans for fertility and do not donate sperm.

3. There are any factors that prevent the smooth progress of PET/CT examination or interfere with the interpretation of imaging results, including but not limited to the following situations: such as inability to lie flat, remain still or tolerate PET/CT scanning; It is known that there are metal implants or joint prostheses, etc.

4. It is known that there is an allergy or contraindication to any component of the test drug or its preparation.

5. Patients who had a second primary malignant tumor other than prostate cancer before enrollment, excluding malignant tumors with a low risk of metastasis and death that have been cured (5-year survival rate >90%), such as superficial squamous cell carcinoma of the skin, low-grade superficial bladder cancer, etc.

6. History of neurological or mental disorders, including epilepsy or dementia.

7. Participating in other clinical studies or having less than 4 weeks since the end of the last administration of the previous clinical study at the time of the first administration.

Exclusion Criteria

1. Combined with the following diseases:

1. . Severe urinary incontinence, hydronephrosis, severe urinary dysfunction, etc. Note: Subjects with bladder outflow tract obstruction or urinary incontinence who can be controlled through the existing best standard treatment (including urinary pads, drainage, etc.) are eligible to participate in the study.

2. . Concurrent active infection or unexplained fever >38.5℃ for more than 1 hour during the screening period and before administration.

3. . Combined with severe or poorly controlled systemic diseases, including but not limited to poorly controlled diabetes, congestive heart failure, unstable angina pectoris, myocardial infarction that occurred within 6 months before administration, refractory hypertension, acute kidney injury, stroke, and severe liver injury.

4. . Combined with active hepatitis B (HBV-DNA testing is required for HBsAg positive patients, and HBV DNA≥2000 IU/mL or 104 copies/mL), active hepatitis C (HCV-Ab positive and higher than the detection limit of the analytical method).

5. . Those who are known to have tested positive for acquired immunodeficiency syndrome (AIDS) or human immunodeficiency virus (HIV).

6. . Active syphilis infected individuals.

• Minimum Eligible Age: 18 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: No

Sponsors

Jiangsu HengRui Medicine Co., Ltd.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Beijing Cancer Hospital

Beijing, Beijing Municipality, China

Countries

China

Central Contacts

Yan Xuan

Role: CONTACT

yan.xuan.yx3@hengrui.com

+86-0518-82342973

Facility Contacts

Zhi Yang

Role: primary

pekyz@163.com

+86-010-88197842

Peng Du

Role: backup

dupeng9000@126.com

+86-010-88197842

Other Identifiers

HRS-1738-101

Identifier Type: -

Identifier Source: org_study_id