Immunogenicity and Safety of Different Dosages of Rabies Vaccine (Serum-free Vero Cell)

NCT ID: NCT07055880

Last Updated: 2025-07-09

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: PHASE2
• Total Enrollment: 120 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-07-28
• Study Completion Date: 2026-01-15

Brief Summary

To describe the immunogenicity and safety of two dosages of Sinovac rabies vaccine, as well as compared the differences with the marked WHO PQ rabies vaccine Verorab® in a post-exposure prophylaxis (PEP) schedule.

Detailed Description

This is a Phase Ⅱ, randomized, double-blind, active-controlled, dose-finding study. A total of 120 healthy participants aged 18~59 years old will be enrolled. All participants will be randomized at a 1:1:1 ratio to three armes, which receive low-dosage Sinovac rabies vaccine, high-dosage Sinovac rabies vaccine or Sanofi Pasteur Verorab®, in an Essen schedule of 5 doses at D0, 3, 7, 14, 28 through intramuscular route (IM) as a simulated rabies PEP.

Blood samples for immunogenicity assessment will be collected at D0, D14, D28, and D42. For safety assessment, the solicited local and systemic AEs within 7 days after each-dose vaccination (If the vaccination interval is less than 7 days, the actual interval shall prevail), as well as unsolicited AEs from the first-dose vaccination until 28 days after the last-dose vaccination will be actively monitored. SAEs will also be collected during the whole study period.

Conditions

Rabies

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: QUADRUPLE

Study Groups

Sinovac rabies vaccine

Participants will be randomly assigned to receive either low-dose or high-dose Sinovac rabies vaccine.

Group Type: EXPERIMENTAL

Rabies Vaccine (Serum-free Vero Cell), Freeze-dried

Intervention Type: BIOLOGICAL

Receiving five doses of rabies vaccine manufactured by Sinovac using the "Essen" PEP schedule

Sanofi Pasteur Verorab®

Participants will be randomly assigned to receive the marketed rabies vaccine Verorab®

Group Type: ACTIVE_COMPARATOR

Verorab®

Intervention Type: BIOLOGICAL

Receiving five doses of marketed rabies vaccine manufactured by Sanofi using the "Essen" PEP schedule

Interventions

Rabies Vaccine (Serum-free Vero Cell), Freeze-dried

Receiving five doses of rabies vaccine manufactured by Sinovac using the "Essen" PEP schedule

Intervention Type: BIOLOGICAL

Verorab®

Receiving five doses of marketed rabies vaccine manufactured by Sanofi using the "Essen" PEP schedule

Intervention Type: BIOLOGICAL

Eligibility Criteria

Inclusion Criteria

1. Populations aged 18~59 years old;

2. Participants are able to understand and sign the informed consent form (ICF) voluntarily;

3. Participants are able to comply with the study procedures based on the investigator's assessment;

4. In a stable health status (defined as a stable preexisting disease status during the past 3 months, i.e., no change in treatment or hospitalization due to exacerbation of preexisting diseases);

5. Participant was tested negative for HIV, Syphilis, Hepatitis B, Hepatitis C infection at the screening of this study (the test result should be provided);

6. Female participants of childbearing potential were tested negative for urine pregnancy test pre-vaccination, and also need to have effective contraceptive measures in the previous 2 weeks pre-vaccination;

7. Participants of childbearing potential and their partners are willing to take effective contraceptive measures and have no sperm or ovum donation plan from the time of signing ICF to 28 days after the last dose of vaccination;

8. Participants should provide verifiable identifications, and contact or be contacted with the investigators during the study period.

Exclusion Criteria

1. Fever on vaccination day, with axillary temperature >37.0°C pre-vaccination;

2. Previous vaccination against rabies (in pre- or post-exposure regimen) with either trial vaccines or licensed vaccines;

3. Previous administration with rabies immunoglobulins or monoclonal antibodies;

4. Bite by, or exposure to a potentially rabid animal in the previous 12 months with category Ⅱ or Ⅲ exposures;

5. Female participants who are currently lactating or pregnant;

6. Known serious allergy to vaccines or vaccine ingredients, such as severe urticaria, anaphylactic shock, allergic laryngeal edema, allergic purpura, or known other serious adverse reactions to vaccine;

7. With severe congenital malformations or developmental disorders, genetic defects, severe malnutrition;

8. With autoimmune diseases, immunodeficiency diseases (including but not limited to systemic lupus erythematosus, ankylosing spondylitis, autoimmune thyroid diseases, asplenia, functional asplenia, and HIV infection);

9. With poor controlled chronic illnesses or history of severe diseases, including but not limited to cardiovascular diseases, hematological disorders, liver and kidney diseases, digestive system disorders, respiratory diseases, malignancies, a history of major organ transplantation, drug-uncontrolled hypertension (with systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg), or any other disease or medical condition that the investigator believes could interfere with the trial results;

10. With current or past history of severe neurological diseases (epilepsy, convulsions or seizures [excluding history of febrile seizures]) or psychiatric disorders, or presence of a family history of psychiatric disorders;

11. With coagulation disorders (eg. factor deficiency, platelet disorders), or history of bleeding, hematoma, or bruising following intramuscular injections or venipuncture;

12. Receipt of ≥14 days of immunosuppressive or other immunomodulatory therapy (prednisone ≥2mg/kg/day, or its equivalent), cytotoxic therapy within 180 days prior to screening, or plans for such treatment in this study;

13. With long-term alcohol abuse [>14 drinks per week (1 drink =14 g 100% alcohol =360 mL beer, or 150 mL wine, or 45 mL distilled liquor/liquor)] or substance abuse (repeated and heavy use of narcotic drugs, psychotropic drugs, volatile organic solvents, etc.)

14. Receipt of blood products or immunoglobulins within 180 days prior to screening, or plans to receive these treatments in the study;

15. Receipt of other investigational drugs/vaccines within 30 days prior to screening, or plans to receive such drugs or vaccines during the study period;

16. Currently participating in other vaccine or drug clinical trials, or plan to participate in other clinical trials during the study;

17. Receipt of live-attenuated vaccines within 14 days prior to screening, or subunit or inactivated vaccines within 7 days prior to screening;

18. Presence of skin injuries, inflammation, ulcers, rashes, scars, or other conditions at the intended vaccination site that may interfere with drug administration or observation of local reactions;

19. Acute onset of various acute diseases or chronic diseases within the past 7 days, or known or suspected active infections;

20. Any other factors considered by the investigator to make the participant unsuitable for participation in the study

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 59 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Sinovac Biotech Co., Ltd

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Ali Faisal Saleem

Role: PRINCIPAL_INVESTIGATOR

Vice Chair, Department of Pediatrics and Child Health, The Aga Khan University, Karachi, Pakistan

Nosheen Nasir, Dr.

Role: PRINCIPAL_INVESTIGATOR

Aga Khan University

Locations

The Aga Khan University

Karachi, , Pakistan

Countries

Pakistan

Central Contacts

Ali Faisal Saleem, Dr.

Role: CONTACT

ali.saleem@aku.edu

+92 21 34864718

Nosheen Nasir, Dr.

Role: CONTACT

nosheen.nasir@aku.edu

+92 21 34864595

Facility Contacts

Ali Faisal Saleem

Role: primary

ali.saleem@aku.edu

+92 21 34864718

Nosheen Nasir

Role: backup

nosheen.nasir@aku.edu

+92 21 34864595

Other Identifiers

PRO-PVRV-sf-2001

Identifier Type: -

Identifier Source: org_study_id