The Efficacy of Sequential RT After Triple Therapy for uHCC

NCT ID: NCT07052448

Last Updated: 2025-07-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Total Enrollment

35 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-11-01

Study Completion Date

2026-06-30

Brief Summary

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Triple therapy of transcatheter arterial chemoembolization (TACE) combined with lenvatinib and anti-PD-1 antibodies has demonstrated excellent efficacy in unresectable hepatocellular carcinoma (uHCC). However, tumor drug resistance is still a major problem and many patients fail to achieve complete necrosis of the lesions after treatment. This study aimed to investigate the efficacy and safety of sequential radiotherapy after triple therapy in patients with uHCC to improve tumor response rate.

Detailed Description

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Conditions

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Hepatocellular Carcinoma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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sequential radiotherapy after triple therapy

Patients with unresectable hepatocellular carcinoma received sequential radiotherapy after the combination of transcatheter arterial chemoembolization with lenvatinib and anti-PD-1 antibodies

sequential radiotherapy after the combination of transcatheter arterial chemoembolization (TACE) combined with lenvatinib and anti-PD-1 antibodies

Intervention Type DRUG

sequential radiotherapy after the combination of transcatheter arterial chemoembolization (TACE) combined with lenvatinib and anti-PD-1 antibodies

Interventions

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sequential radiotherapy after the combination of transcatheter arterial chemoembolization (TACE) combined with lenvatinib and anti-PD-1 antibodies

sequential radiotherapy after the combination of transcatheter arterial chemoembolization (TACE) combined with lenvatinib and anti-PD-1 antibodies

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients diagnosed with HCC and assessed as unresectable by multidisciplinary team (MDT)
* Patients who achieved PR or SD after triple therapy according to the mRECIST and did not meet the criteria for radical surgical resection or could not tolerate surgical treatment
* Patients who received sequential radiotherapy
* Age between 18 and 75 years
* Child-Pugh class A or B
* Eastern Cooperative Oncology Group performance status (ECOG PS) score of 0-1

Exclusion Criteria

* Previous acceptance of other antitumor treatments
* Treatment in conjunction with other treatment regimens, such as radiofrequency ablation and chemotherapy
* History of other malignancies
* Incomplete data.
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fujian Provincial Hospital

OTHER

Sponsor Role lead

Responsible Party

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Mao-Lin Yan

professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Fuzhou University Affiliated Provincial Hospital

Fuzhou, Fujian, China

Site Status

Countries

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China

Other Identifiers

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TALENP006

Identifier Type: -

Identifier Source: org_study_id

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