Prospective Cohort and Biobank of Patients With Nonalcoholic Fatty Liver Disease

NCT ID: NCT07051863

Last Updated: 2025-07-09

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 200 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2023-07-19
• Study Completion Date: 2030-12-31

Brief Summary

The goal of this observational study is to establish a unified cohort for retrospective and prospective high quality baseline and follow-up data registration of patients with a diagnosis of NAFLD/NASH/MAFLD, according to standardized criteria.

This will allow future studies aimed at elucidate clinical presentation, natural history, response to treatment, genetic and metabolic risk factors, treatment options and outcomes of the disease. The cohort will allow investigators to carry out genetic, serological, microbiologic and immunological studies.

Conditions

NAFLD; MASH; NASH/MASH

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

1. Participant must be ≥ 18 years of age at the time of signing the informed consent

2. Participant willing to sign the informed consent form (ICF) and to complete all study-specific procedures and visits

3. To have a diagnosis of NAFLD/NASH/MAFLD followed at Epatocentro Ticino and collaborating/referring clinicians based on:

1. Liver biopsy with a histological evidence of NAFLD/NASH/MAFLD OR

2. Liver imaging (ultrasound, CT scan, MRI, CAP Controlled Attenuation Parameter) OR

3. Diagnosis of metabolic syndrome and liver fibrosis or cirrhosis without an alternative diagnosis; metabolic syndrome fulfilling one or more of the below mentioned conditions:

• Abdominal obesity: a waist circumference of more than 35 inches (>89cm) for women and more than 40 inches (>102 cm) for men;
• High blood pressure of 130/80 mm Hg or higher. Normal blood pressure is defined as less than 130 mm Hg for systolic pressure, and less than 80 mm Hg for diastolic pressure
• Impaired fasting blood glucose. This means a level equal to or greater than 100 mg/dL (>5.6 mmol/L)
• High triglyceride levels of more than 150 mg/dL (> 1.7mmol/L).
• Low HDL (good) cholesterol: less than 40 mg/dL (< 1.04 mmol/L) for men and less than 50 mg/dL (< 1.29 mmol/L) for women

4. alcohol consumption less than 21 (males) or 14 (women) units per week in the 6 months before the enrolment and no history of excessive alcohol consumption in the 5 years before enrolment. One unit is 12g (grams) of pure alcohol; 10-12 grams of pure alcohol are contained in a 280-330 ml of beer, 150-180 ml of champagne, 30-40 ml of whisky or high-strength spirit, 60-80 ml of liqueur, and 100-120 ml of red wine

Exclusion Criteria

1. To have a diagnosis of type I diabetes mellitus

2. To have a concomitant liver disease

3. To take or have taken in the last 12 months before enrolment, on more than 50% of days, drugs that may cause liver steatosis (long-term high dose systemic corticosteroids (> 20mg prednisone equivalent), amiodarone, methotrexate, tamoxifen, tetracycline, high dose estrogens and valproic acid)

4. Pregnancy and breast feeding.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Fondazione Epatocentro Ticino

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Fondazione Epatocentro Ticino

Lugano, Canton Ticino, Switzerland

Site Status: RECRUITING

Countries

Switzerland

Central Contacts

Andreas Cerny, Prof. Dr. med

Role: CONTACT

andreas.cerny@hin.ch

0041919106570

Maurizia Bissig

Role: CONTACT

maurizia.bissig@hin.ch

Facility Contacts

Andreas Cerny, Prof. Dr. med

Role: primary

andreas.cerny@hin.ch

0041919106570

Maurizia Bissig

Role: backup

maurizia.bissig@hin.ch

Other Identifiers

NAFLD Cohort Study

Identifier Type: -

Identifier Source: org_study_id