Liposomal Irinotecan (II) Fractionated Dosing Combined With 5-FU/LV (FOLFIRInali-3) and Bevacizumab in Second-line Treatment of Advanced Colorectal Cancer: A Single-arm, Phase II Clinical Study

NCT ID: NCT07047560

Last Updated: 2025-07-02

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: PHASE2
• Total Enrollment: 46 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-09-01
• Study Completion Date: 2027-08-01

Brief Summary

This is an investigator-initiated, prospective, multicenter, single-arm phase II clinical study. It aims to evaluate the efficacy and safety of fractionated liposomal irinotecan (II)-based combination chemotherapy (FOLFIRInali-3) plus bevacizumab (Bev) as second-line treatment for advanced colorectal cancer, with the primary endpoint being objective response rate (ORR).

Eligible subjects will receive second-line treatment with the FOLFIRInali-3 （Liposomal irinotecan (II) fractionated dosing combined with 5-FU/LV） plus bevacizumab (Bev) 。Treatment will be discontinued upon occurrence of any of the following: Disease progression (radiologically confirmed)，intolerable toxicity (unmanageable after dose modification)， initiation of new antitumor therapy, withdrawal of informed consent or investigator's discretion (based on clinical judgment). Patients received regular and periodic reviews, with imaging evaluations every 6 weeks.

Detailed Description

This is an investigator-initiated, prospective, multicenter, single-arm phase II clinical study. It aims to evaluate the efficacy and safety of fractionated liposomal irinotecan (II)-based combination chemotherapy (FOLFIRInali-3) plus bevacizumab (Bev) as second-line treatment for advanced colorectal cancer, with the primary endpoint being objective response rate (ORR).

Prospective participants must undergo screening assessments within 28 days before randomization to determine eligibility. Eligible subjects will receive second-line treatment with the FOLFIRInali-3 plus bevacizumab (Bev) regimen as follows:

1. Liposomal irinotecan (II): 30 mg/m² IV on D1 and D3

2. Fluorouracil (5-FU):

• 400 mg/m² IV bolus on D1
• Followed by 2400 mg/m² continuous IV infusion over 46-48 hours

3. Leucovorin (LV): 400 mg/m² IV infusion on D1

4. Bevacizumab: 5 mg/kg IV infusion on D1。

Treatment will be discontinued upon occurrence of any of the following:

1. Disease progression (radiologically confirmed)

2. Intolerable toxicity (unmanageable after dose modification)

3. Initiation of new antitumor therapy

4. Withdrawal of informed consent

5. Investigator's discretion (based on clinical judgment)

Patients received regular and periodic reviews, with imaging evaluations every 6 weeks.

Conditions

Colorectal Cancer (CRC)

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Liposomal irinotecan (II) fractionated dosing combined with 5-FU/LV and bevacizumab

Liposomal irinotecan (II): 30 mg/m² IV on D1 and D3, Q2W Fluorouracil (5-FU): Q2W

• 400 mg/m² IV bolus on D1
• Followed by 2400 mg/m² continuous IV infusion over 46-48 hours Leucovorin (LV): 400 mg/m² IV infusion on D1 Bevacizumab: 5 mg/kg IV infusion on D1, Q2W

Group Type: EXPERIMENTAL

fractionated liposomal irinotecan (II)-based combination chemotherapy (FOLFIRInali-3) plus bevacizumab (Bev)

Intervention Type: DRUG

Liposomal irinotecan (II): 30 mg/m² IV on D1 and D3, Q2W; Fluorouracil (5-FU): Q2W;

• 400 mg/m² IV bolus on D1
• Followed by 2400 mg/m² continuous IV infusion over 46-48 hours Leucovorin (LV): 400 mg/m² IV infusion on D1 Bevacizumab: 5 mg/kg IV infusion on D1, Q2W.

Interventions

fractionated liposomal irinotecan (II)-based combination chemotherapy (FOLFIRInali-3) plus bevacizumab (Bev)

Liposomal irinotecan (II): 30 mg/m² IV on D1 and D3, Q2W; Fluorouracil (5-FU): Q2W;

• 400 mg/m² IV bolus on D1
• Followed by 2400 mg/m² continuous IV infusion over 46-48 hours Leucovorin (LV): 400 mg/m² IV infusion on D1 Bevacizumab: 5 mg/kg IV infusion on D1, Q2W.

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Signed the informed consent；

2. Male or female patients ≥18 years old;

3. ECOG physical status score is 0 or 1;

4. Patients with pathologically confirmed advanced colorectal carcinoma (all other histological types excluded);

5. Patients who experienced disease progression under either of the following circumstances:During or within 6 months after first-line oxaliplatin-containing chemotherapy, or within 1 year after completing oxaliplatin-based adjuvant chemotherapy post-resection;

6. Expected survival time ≥ 3 months;

7. Patients must have at least one measurable metastatic lesion according to RECIST version 1.1;

8. Normal organ function:

1. Hematology :Absolute neutrophil count (ANC) ≥ 1.5 × 109/L (1500/mm3); Platelet count ≥ 100 × 109/L (100000/mm3); Hemoglobin ≥ 90g/L;

2. Kidney:The calculated value of creatinine clearance rate (CrCl) is ≥ 50 mL/min; Normal urine routine, urine protein<2+or 24-hour (h) urine protein quantification<1.0 g;

3. Liver:Total serum bilirubin (TBiL) ≤ 1.5 × ULN;AST and ALT ≤ 2.5 × ULN; For subjects with liver metastasis, AST and ALT can be ≤ 5 × ULN;Serum albumin (ALB) ≥ 30g/L;

4. Normal coagulation function, international standardized ratio (INR) ≤ 1.5 x ULN, prothrombin time (PT) and activated partial thromboplastin time (APTT) ≤ 1.5 x ULN;

9. Women of childbearing age must undergo a pregnancy test (serum or urine) with a negative result within 14 days before enrollment, and voluntarily use appropriate methods of contraception during the observation period and within 8 weeks after the last administration of the study drug; For males, surgical sterilization or agreement to use appropriate methods of contraception during observation and within 8 weeks after the last administration of study medication should be considered;

10. Comply with the scheduled visits, treatment plans, laboratory tests, and other requirements of the study;

Exclusion Criteria

1. History of other malignancies (except cured basal cell carcinoma or cervical carcinoma in situ);

2. Participation in other drug trials within 4 weeks prior to enrollment;

3. Uncontrolled hypertension (SBP >160 mmHg or DBP >100 mmHg);

4. Acute coronary syndrome (including MI/unstable angina) with coronary angioplasty/stent placement within 6 months;

5. NYHA class II+ heart failure, unstable angina, MI, or severe arrhythmia with cardiovascular impairment within 6 months;

6. Symptomatic brain metastases;

7. Severe comorbidities requiring hospitalization (e.g., ileus, bowel obstruction, pulmonary fibrosis, refractory diabetes, heart/kidney/liver failure, psychiatric/cerebrovascular disorders);

8. Gastrointestinal perforation/fistula, intra-abdominal abscess, or non-GI fistula within 6 months;

9. Concomitant use of strong CYP3A4/CYP2C8 inhibitors/inducers or UGT1A1 inhibitors within 2 weeks;

10. Pregnancy or lactation;

11. Other investigator-determined contraindications.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Tianjin Medical University Cancer Institute and Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Tianjin Medical University Cancer Institute and Hospital

Tianjin, Tianjin Municipality, China

Site Status: RECRUITING

Countries

China

Central Contacts

Ting Deng, MD

Role: CONTACT

xymcdengting@126.com

022-23340123 ext. 1053

Facility Contacts

Ting Deng, MD

Role: primary

xymcdengting@126.com

022-23340123 ext. 1053

Other Identifiers

TJFOLFIRInali-3

Identifier Type: -

Identifier Source: org_study_id