A Phase Ib/II Clinical Study of Regorafenib Combined With Toripalimab and Albumin-bound Paclitaxel for the Third-line Treatment of Advanced Pancreatic Cancer

NCT ID: NCT07040228

Last Updated: 2025-06-27

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: PHASE1/PHASE2
• Total Enrollment: 23 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-05-26
• Study Completion Date: 2027-05-30

Brief Summary

The purpose of this clinical trial is to explore the efficacy and safety of Regorafenib combined with Toripalimab and Paclitaxel-albumin in patients as the third line treatment for patients with unresectable or metastatic pancreatic cancer.The main question it aims to answer is:

Phase Ib: Evaluate the maximum tolerated dose (MTD) of regorafenib and/or phase II clinical recommendations Dose (RP2D).

Phase II: Evaluation of the efficacy and safety of Regorafenib Combined with Terriptylimab and Albumin Paclitaxel for Late Third Line Treatment for pancreatic cancer patients.

Participants will:

Phase Ib: Selected patients will receive treatment with Regorafenib at main dose levels of 40, 80, and 120mg/d (po d1-14 Q3W), Toripalimab(240mg, ivgtt, d1, Q3W), and Paclitaxel-albumi(125mg/m2, ivgtt, d1, 8, Q3W) until disease progression or intolerable toxicity occurs.

Phase II: Regorafenib: Based on the results of the completed Phase I study, determine the dosage for Phase II (po d1-14 Q3W). Toripalimab (240mg, ivgtt, d1, Q3W) and Paclitaxel-albumi (125mg/m2, ivgtt, d1, 8, Q3W) until disease progression or intolerable toxicity occurs.

Conditions

Pancreatic Cancer Metastatic

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Research Scheme Experimental Group

Three line treatment of advanced pancreatic cancer with regofinil combined with teripril monoclonal antibody and albumin paclitaxel

Group Type: EXPERIMENTAL

Regorafenib combined with Toripalimab and Albumin paclitaxel

Intervention Type: DRUG

Regorafenib combined with Toripalimab and Albumin paclitaxel as the third line treatment for patients with advanced pancreatic cancer

Interventions

Regorafenib combined with Toripalimab and Albumin paclitaxel

Regorafenib combined with Toripalimab and Albumin paclitaxel as the third line treatment for patients with advanced pancreatic cancer

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. The patient fully understands this study, voluntarily participates and signs an informed consent form (ICF);

2. Age ≥ 18 years old and ≤ 80 years old;

3. Patients with unresectable/metastatic pancreatic cancer confirmed by histopathology;

4. Imaging confirmation of tumor progression after previous first-line and second-line standard treatment;

5. According to RECIST 1.1 criteria, patients must have at least one measurable target lesion;

6. Eastern Cancer Collaboration Group (ECOG) Physical Fitness Status Score: 0-2 points;

7. Expected survival time ≥ 2 months;

8. Absolute neutrophil count (ANC) ≥ 1.5 × 10 ^ 9/L, platelets ≥ 100 × 10 ^ 9/L, and hemoglobin ≥ 90 g/L (No blood transfusion or blood products within 14 days prior to laboratory examination.

Not treated with granulocyte colony-stimulating factor or other hematopoietic stimulating factors);

9. Liver and kidney function: serum creatinine ≤ 1.5 times the upper limit of normal value; AST and ALT ≤ 2.5 times the upper limit of normal values (≤ 5 times the upper limit of normal values for patients with liver metastases); Total bilirubin ≤ 1.5 times the upper limit of normal value (≤ 3 times the upper limit of normal value for patients with liver metastasis);

10. Women of childbearing age must undergo a pregnancy test (serum) within 7 days before enrollment, and the result must be negative, And willing to use appropriate contraception methods during the trial period and 6 months after the last administration of the trial drug.

Exclusion Criteria

1. Have hypersensitivity reactions to any research drug or its components;

2. Concurrent serious uncontrolled infections or other serious uncontrolled accompanying diseases, moderate or severe kidney injury; (such as progressive infection, uncontrollable hypertension, diabetes, etc.);

3. Heart function and disease meet one of the following conditions:

1. Long QTc syndrome or QTc interval>480 ms;

2. Complete left bundle branch block, grade II or III atrioventricular block;

3. Severe and uncontrolled arrhythmias requiring medication treatment;

4. New York College of Cardiology classification ≥ III;

5. Heart ejection fraction (LVEF) below 50%;

6. History of myocardial infarction, unstable angina, and severe unstable ventricular arrhythmia within 6 months prior to recruitment or any other arrhythmia requiring treatment, history of clinically severe pericardial disease, or there may be electrocardiographic evidence of acute ischemic or active conduction system abnormalities.

4. Active infection of hepatitis B and C (hepatitis B virus surface antigen is positive and hepatitis B virus DNA exceeds 1x103 copies/mL; Hepatitis C virus RNA exceeding 1x103 copies/mL).Asymptomatic chronic carriers of hepatitis B or hepatitis C excluded;

5. Human immunodeficiency virus (HIV) infection (HIV antibody positive);

6. Imaging confirms intestinal obstruction;

7. Previously or currently suffering from other malignant tumors simultaneously (Except for non melanoma basal cell carcinoma and breast/cervical carcinoma in situ that have been effectively controlled and other malignant tumors that have been effectively controlled without treatment in the past five years);

8. Pregnant and lactating women, as well as reproductive age patients who are unwilling to take contraceptive measures;

9. Patients who require treatment for merging with other malignant tumors;

10. History of pulmonary hemorrhage/hemoptysis ≥ grade 2 (defined as at least 2.5mL of bright red blood) within one month prior to the first administration;

11. Within 6 months prior to the first administration, there are arterial embolism, severe bleeding (excluding bleeding caused by surgery), and a tendency for severe bleeding;

12. Merge symptomatic brain metastases, meningeal metastases, spinal cord tumor invasion, and spinal cord compression syndrome;

13. Have used other clinical trial drugs within one month before the first administration;

14. The researchers have determined that patients who are not suitable to participate in this study.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Qilu Pharmaceutical Group Co., Ltd

UNKNOWN

Sponsor Role: collaborator

Shanghai Junshi Biomedical Technology Co., Ltd

UNKNOWN

Sponsor Role: collaborator

Cancer Hospital Chinese Academy of Medical Science, Shenzhen Center

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Cancer Hospital Chinese Academy of Medical Sciences, Shenzhen Center

Shenzhen, Guangdong, China

Site Status: RECRUITING

Countries

China

Central Contacts

Hang Junjie, doctorate

Role: CONTACT

katerhjj0000@126.com

86+13681709736

Other Identifiers

YW2025-28-1

Identifier Type: -

Identifier Source: org_study_id