A Phase I/II Study of TRS005 in Combination With Cyclophosphamide, Doxorubicin, and Prednisone（T-CHP） in Previously Untreated Patients With CD20-positive DLBCL

NCT ID: NCT07035379

Last Updated: 2025-08-22

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: PHASE1/PHASE2
• Total Enrollment: 66 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-09-01
• Study Completion Date: 2028-09-01

Brief Summary

This trial is a multicenter, open-label, single-arm, dose-escalation and dose-expansion clinical trial. The dose was increased according to the "3 + 3" rule. Patients with previously untreated patients with CD20-positive DLBCL were selected to evaluate the safety, tolerance (DLT, MTD), pharmacokinetics, and anti-tumor activity of TRS005 in combination with standard doses of cyclophosphamide, doxorubicin, and prednisone（T-CHP） by intravenous drip every 3 weeks.

Conditions

Diffuse Large B-Cell Lymphoma (DLBCL)

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

TRS005+CHP

TRS005 in Combination With Cyclophosphamide, Doxorubicin, and Prednisone（T-CHP）

Group Type: EXPERIMENTAL

TRS005

Intervention Type: DRUG

TRS005 will be administered at a starting dose of 0.8mg/kg IV every 3 weeks (starting from Cycle 1 Day 1), for 6 cycles (up to 8).

Cyclophosphamide

Intervention Type: DRUG

Cyclophosphamide will be administered at 750 milligrams per square meter (mg/m\^2) IV every 3 weeks (starting from Cycle 1 Day 1), for 6 cycles.

Doxorubicin

Intervention Type: DRUG

Doxorubicin will be administered at 50 mg/m\^2 IV every 3 weeks (starting from Cycle 1 Day 1), for 6 cycles.

Prednisolone

Intervention Type: DRUG

Prednisolone will be administered at 100 mg orally daily for 5 days every 3 weeks (starting from Cycle 1 Day 1), for 6 cycles.

Interventions

TRS005

TRS005 will be administered at a starting dose of 0.8mg/kg IV every 3 weeks (starting from Cycle 1 Day 1), for 6 cycles (up to 8).

Intervention Type: DRUG

Cyclophosphamide

Cyclophosphamide will be administered at 750 milligrams per square meter (mg/m\^2) IV every 3 weeks (starting from Cycle 1 Day 1), for 6 cycles.

Intervention Type: DRUG

Doxorubicin

Doxorubicin will be administered at 50 mg/m\^2 IV every 3 weeks (starting from Cycle 1 Day 1), for 6 cycles.

Intervention Type: DRUG

Prednisolone

Prednisolone will be administered at 100 mg orally daily for 5 days every 3 weeks (starting from Cycle 1 Day 1), for 6 cycles.

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• 1. Part I: Age 18 -65 years old; Part II: Aged ≥ 18 years old, both male and female.
• 2. Previously untreated patients with CD20-positive DLBCL diagnoses by 2022 WHO.
• 3. Measurable disease of at least 15mm (node)/10mm (extranodal).
• 4. ECOG performance status 0-2.
• 5. International Prognostic Index (IPI) score of 2-5.
• 6. Estimated survival time ≥6 months.
• 7. Having sufficient organ function.
• 8. Female and male patients of childbearing age and their spouses are willing to carry out adequate contraception throughout the study period, and female patients of childbearing age must have negative serum pregnancy test within 7 days before the first administration.
• 9. Patients voluntarily agree to participate in the study and to sign the informed consent form.

Exclusion Criteria

• 1. Contraindication to any of the individual components of study drugs, including prior receipt of xenoproteins, biological agents.
• 2. Serologic evidence of chronic hepatitis B virus (HBV) infection and unable or unwilling to receive standard prophylactic antiviral therapy or with detectable HBV viral load; Serologic evidence of hepatitis C virus (HCV) infection without completion of curative treatment or with detectable HCV viral load; Human immunodeficiency virus (HIV) seropositive.
• 3. Clinically apparent central nervous system (CNS) lymphoma.
• 4. Patient has ≥ Grade 2 peripheral neuropathy.
• 5. Investigator-assessed diabetes uncontrolled by drug therapy.
• 6. Clinically significant third space fluid accumulation.
• 7. Patients with other malignancies within the past 5 years.
• 8. With active autoimmune diseases.
• 9. Accompanied by serious cardiovascular diseases.
• 10. Accompanied by serious diseases and serious active infections.
• 11. The dosage of steroid hormone (prednisone phase equivalent) used greater than 20mg/ day within 28 days prior to first administration for more than 14 consecutive days, or immunosuppressive treatment.
• 12. Various vaccines were inoculated within 28 days prior to first administration;
• 13. Major surgery (except diagnostic biopsy) within 28 days prior to first administration or during the study period.
• 14. Participate in clinical trials of other drugs or medical devices within 28 days prior to first administration.
• 15. Serious medical or psychiatric illness likely to interfere with participation in this study.
• 16. Investigators assessed as unsuitable to participate in this study for other reasons.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Zhejiang Teruisi Pharmaceutical Inc.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Chinese Academy of Medical Sciences, Cancer Hospital

Beijing, Beijing Municipality, China

Countries

China

Central Contacts

Chen Wang

Role: CONTACT

chen.wang@teruisipharm.com

(+86)18832374527

Other Identifiers

TRS00501003

Identifier Type: -

Identifier Source: org_study_id