A Study of Epcoritamab With Lenalidomide and Tafasitamab in People With Diffuse Large B Cell Lymphoma

NCT ID: NCT07030699

Last Updated: 2025-12-31

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: PHASE2
• Total Enrollment: 27 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-08-13
• Study Completion Date: 2028-08-31

Brief Summary

The researchers are doing this study to find out whether the combination of epcoritamab with tafasitamab and lenalidomide is a safe and effective treatment for relapsed or refractory DLBCL. This is the first time the combination of drugs is being tested.

Conditions

Lymphoma

Keywords

Large B cell lymphoma; Transformed indolent lymphoma; Primary mediastinal B cell lymphoma; High grade B cell lymphoma; Follicular lymphoma grade 3B; Epcoritamab; Lenalidomide; Tafasitamab; 25-070

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Epcoritamab with Lenalidomide and Tafasitamab

Epcoritamab: Subcutaneous, once weekly in cycles 1-3; every 4 weeks cycles 4-12. Tafasitamab: Intravenous, once weekly during cycles 1-3, then every 2 weeks during cycle 4-12. Lenalidomide: Oral, daily on days 1-21 of a 28-day cycle.

Group Type: EXPERIMENTAL

Epcoritamab

Intervention Type: DRUG

Subcutaneous, once weekly in cycles 1-3; every 4 weeks cycles 4-12

Lenalidomide

Intervention Type: DRUG

Oral, daily on days 1-21 of a 28-day cycle

Tafasitamab

Intervention Type: DRUG

Intravenous, once weekly during cycles 1-3, then every 2 weeks during cycle 4-12

Interventions

Epcoritamab

Subcutaneous, once weekly in cycles 1-3; every 4 weeks cycles 4-12

Intervention Type: DRUG

Lenalidomide

Oral, daily on days 1-21 of a 28-day cycle

Intervention Type: DRUG

Tafasitamab

Intravenous, once weekly during cycles 1-3, then every 2 weeks during cycle 4-12

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Age ≥ 18 years
• Pathologically confirmed diffuse large B cell lymphoma, transformed indolent lymphoma, primary mediastinal B cell lymphoma, high grade B cell lymphoma, follicular lymphoma grade 3B
• Subjects must have histologically confirmed CD20+ lymphoma as documented in the most recent representative pathology report.
• Presence of CD19 is not required to be confirmed (except if patients have received anti-CD19 therapy in the past). Patients treated with prior anti-CD19 therapy must have confirmation of CD19 expression in a biopsy done after progression on the last CD19 directed therapy.
• At least 2 prior lines of systemic therapy including CART or ASCT (up to 4 prior lines of therapy allowed). Note that bridging therapy prior to ASCT or CART will be counted as a separate line of therapy)
• At least one prior line of systemic therapy for patients ineligible for ASCT/CART or patients unwilling to undergo CAR-T/ASCT for logistic or other reasons (up to 4 prior lines of therapy allowed)
• Have radiologically measurable lymphadenopathy or extranodal involvement.
• Eastern Cooperative Oncology Group performance status (PS) ≤ 2 (ECOG >2 can be enrolled if PS compromised from lymphoma e.g. spinal cord compression and expected to improve rapidly with therapy)
• Must have adequate organ and marrow status Hemoglobin ≥8 g/dL (red blood cell transfusions are allowed)

• Absolute neutrophil count (ANC) ≥1,000/mm^3 or ≥500/mm^3 if due to disease involvement in the bone marrow (G-CSF use is allowed).
• Platelet count ≥75,000 cells/mm^3 or ≥50,000/mm^3 if due to disease involvement in the bone marrow (platelets transfusions are allowed)
• Estimated Creatinine Clearance (CrCl) ≥40 mL/min (Cockcroft-Gault formula or other institutional standard methods)
• Serum aspartate transaminase (AST) or alanine transaminase (ALT) ≤2.5 x upper limit of normal (ULN)
• Direct bilirubin ≤ 2 x ULN (≤3 if due to Gilbert's syndrome or liver involvement by the lymphoma)
• Negative HIV test at screening, with the following exception: Individuals with a positive HIV test at screening are eligible provided, prior to enrollment, they are stable on antiretroviral therapy for at least 1 year, have a CD4 count ≥ 200/μL, and have an undetectable viral load.
• Signed Informed Consent Form(s)
• Ability to comply with all the study-related procedures, in the investigator's judgement
• Subject is willing to take aspirin prophylaxis (subjects with low or intermediate risk for thromboembolism) or prophylactic anticoagulant (if high risk for a thromboembolic event)
• Contraception requirements

• Patient is willing to adhere to pregnancy risk minimization plan associated with lenalidomide treatment.
• For all females of child-bearing potential; a negative serum pregnancy test (beta-hCG) at the Screening Visit and a negative serum or urine pregnancy test at baseline prior to the first dose of study drug.
• Female subjects of childbearing potential must practice at least 2 protocol-specified methods of birth control, that are effective from 30 days prior to treatment through at least 12 months after the last dose of study drug.
• Female subjects of non-childbearing potential do not need to use birth control.
• Female who is not pregnant, breastfeeding, donating eggs (ova, oocytes), or considering
• becoming pregnant during the study or for 12 months after the last dose of study drug.
• If male, and subject is sexually active with female partner(s) of childbearing potential, he must agree, from 30 days prior to treatment initiation through 12 months after the last dose of study drug, to practice the protocol-specified contraception.
• Male who is not considering fathering a child or donating sperm during the study or for 12 months after the last dose of study drug.
• COVID19 eligibility criteria: Patient should have no known active severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. If a patient has signs/symptoms suggestive of SARS-CoV-2 infection or have had recent known exposure to someone with SARS-CoV-2 infection, the subject must have a negative molecular (e.g., PCR) test, or 2 negative antigen test results at least 24 hours apart, to rule out SARS-CoV-2 infection. Note: SARS-CoV-2 diagnostic tests should be applied following local requirements/recommendations.
• Subjects who do not meet SARS-CoV-2 infection eligibility criteria must be screen failed and may only rescreen after they meet the following SARS-CoV-2 infection viral clearance criteria:

• No signs/symptoms suggestive of active SARS-CoV-2 infection
• Negative molecular (e.g., PCR) result or 2 negative antigen test results at least 24 hours apart

Exclusion Criteria

• Prior CD3/CD20 BiAb based therapy with the following exceptions:

• Patients who received prior CD3/CD20 BiAb as part of frontline therapy for DLBCL and were in remission for at least 1 year post frontline therapy are allowed
• Patients who received prior CD3/CD20 BiAb as part of bridging therapy prior to CAR-T cell therapy without documentation of refractory/progressive disease on CD/CD30 BiAb are allowed
• Patients who received prior CD3/CD20 BiAb and were in remission for atleast 6 months after last dose of drug are allowed
• Prior tafasitamab and/or lenalidomide therapy for lymphoma (Patients who received prior tafasitamab and/or lenalidomide as part of frontline therapy for DLBCL and were in remission for at least 1 year post frontline therapy are allowed)
• Active CNS involvement (previously treated CNS lymphoma is permissible)
• Active secondary malignancy

• Patients who have a concurrent malignancy that is clinically stable and does not require tumor-directed treatment is allowed e.g., low grade prostate cancer under surveillance
• Patients with a previously treated malignancy should be eligible to participate if all treatment of that malignancy was completed at least 2 years before registration and the patient has no evidence of disease.
• Uncontrolled HIV or active HBV or HCV infection (controlled HIV with undetectable viral load, previously treated HBV and HCV are allowed if HBV DNA and HCV RNA are negative respectively, HBcAb positive with HBsAg negative disease is permitted if patient is willing to take entecavir prophylaxis)
• Known active or latent tuberculosis
• Prior solid organ transplantation
• Prior allogeneic stem cell transplantation
• Uncontrolled active systemic infection
• Major surgery within 4 weeks of the first dose of study drug (exceptions may be allowed after discussion with PI if patient has fully recovered from procedure and anti-lymphoma therapy is urgently needed)
• Known clinically significant cardiovascular disease, including:

• Onset of unstable angina pectoris within 6 months of signing ICF
• Acute myocardial infarction within 6 months of signing ICF
• Congestive heart failure (grade III or IV as classified by the New York Heart Association and/or known decrease ejection fraction of <45%)
• Stroke or intracranial hemorrhage within 6 months prior to signing ICF In case of any other history of major cardiovascular disease, a cardiology consult is required within 60 days of enrollment
• Any life-threatening illness, medical condition, or organ system dysfunction that, in the investigator's opinion, could compromise the subject's safety or risk study outcomes
• Vaccination with live vaccines within 28 days prior to enrollment

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Genmab

INDUSTRY

Sponsor Role: collaborator

Incyte Corporation

INDUSTRY

Sponsor Role: collaborator

Memorial Sloan Kettering Cancer Center

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Pallawi Torka, MD

Role: PRINCIPAL_INVESTIGATOR

Memorial Sloan Kettering Cancer Center

Locations

Memorial Sloan Kettering Basking Ridge (All Protocol Activities)

Basking Ridge, New Jersey, United States

Site Status: RECRUITING

Memorial Sloan Kettering Monmouth (All Protocol Activities)

Middletown, New Jersey, United States

Site Status: RECRUITING

Memorial Sloan Kettering Bergen (All Protocol Activities)

Montvale, New Jersey, United States

Site Status: RECRUITING

Memorial Sloan Kettering Cancer Center Suffolk - Commack (All Protocol Activities)

Commack, New York, United States

Site Status: RECRUITING

Memorial Sloan Kettering Westchester (All Protocol Activities)

Harrison, New York, United States

Site Status: RECRUITING

Memorial Sloan Kettering Cancer Center (All Protocol Activities)

New York, New York, United States

Site Status: RECRUITING

Memorial Sloan Kettering Nassau (All Protocol Activities)

Uniondale, New York, United States

Site Status: RECRUITING

Countries

United States

Central Contacts

Pallawi Torka, MD

Role: CONTACT

Phone: 201-775-7808

Email: torkap@mskcc.org

Paul Hamlin, MD

Role: CONTACT

Phone: 646-608-1667

Facility Contacts

Pallawi Torka, MD

Role: primary

Pallawi Torka, MD

Role: primary

Pallaw Torka, MD

Role: primary

Pallawi Torka, MD

Role: primary

Pallawi Torka, MD

Role: primary

Pallawi Torka, MD

Role: primary

Pallawi Torka, MD

Role: primary

Related Links

http://www.mskcc.org

Memorial Sloan Kettering Cancer Center

Other Identifiers

25-070

Identifier Type: -

Identifier Source: org_study_id