Prospective Study of EXErcise Regimens After Treatment for Breast Cancer for Hypertrophy and Conditioning

NCT ID: NCT07023887

Last Updated: 2025-06-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

15 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-05-21

Study Completion Date

2026-05-14

Brief Summary

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This study investigates the impact of four standard of care, monitored group exercise regimens (resistance training) on conditioning and hypertrophy in women previously treated for breast cancer. The study will compare two conditioning regimens (6-12-25 and 8x8) and two hypertrophy regimens (5/5/5 cluster sets and double training) to assess changes in VO2 max, muscle mass, and fat mass.

Detailed Description

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Conditions

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Cancer Breast Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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6-12-25 Training Regimen

A conditioning regimen involving three exercises performed consecutively with minimal rest. Includes 4-6 repetitions at 4-0-1-0 tempo, 10-12 repetitions at 3-0-1-0 tempo, and 20-25 repetitions at 2-0-1-0 tempo.

Intervention Type OTHER

8x8 Training Regimen

A conditioning regimen optimizing high volume with short rest periods. Six exercises are performed consecutively with a 2-0-1-0 tempo and no rest between sets.

Intervention Type OTHER

5/5/5 Cluster Set Training Regimen

A hypertrophy regimen where an individual performs 5 repetitions at a tempo of 4 seconds during the eccentric movement of the exercise, while performing the concentric motion in 1 second then resting for 20 seconds and repeating the sequence two additional times to total three clusters of 5 repetitions.

Intervention Type OTHER

Double Training Regimen

A hypertrophy regimen adding an additional set of lesser repetitions for a specified exercise at the end of a tri-set of exercises.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Age 20-89 years
2. Women prescribed exercise as a Standard of Care
3. Women with a biopsy proven diagnosis of ductal carcinoma in situ (DCIS) or invasive carcinoma of the breast
4. Women must have undergone treatment for breast cancer, including one or more of the following: surgery, radiation therapy, chemotherapy, immunotherapy, or hormonal therapy.
5. Women undergoing active chemotherapy are not allowed on study. Immunotherapy or targeted agent usage is allowed.
6. Women with \> 6 months of resistance training experience under expert guidance by a CSCS

Exclusion Criteria

1. Any current treatment with cytotoxic chemotherapy for breast cancer
2. Inability to safely engage in group sessions of resistance training as deemed by study Pl
3. Severe arthritic, joint, cardiovascular, or musculoskeletal condition deemed by Pl to be unsafe to engage in resistance training
4. Beta blocker or GLP-1 inhibitor medications
5. Pregnant women
6. Males
Minimum Eligible Age

20 Years

Maximum Eligible Age

89 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

OTHER

Sponsor Role lead

Responsible Party

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Colin Champ, MD

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Colin Champ

Role: PRINCIPAL_INVESTIGATOR

AHN Radiation Oncology

Locations

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Allegheny General Hospital

Pittsburgh, Pennsylvania, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Clinical Trials Contact

Role: CONTACT

412-330-6151

Facility Contacts

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Clinical Trials Contact

Role: primary

Other Identifiers

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2025-076-SG

Identifier Type: -

Identifier Source: org_study_id

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