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NLR and PLR Levels Following PENG Block in Hip Arthroplasty

NCT ID: NCT07023107

Last Updated: 2025-12-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-06-16

Study Completion Date

2025-12-09

Brief Summary

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Effect of PENG block on NLR and PLR following hip arthroplasty

Detailed Description

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The NLR is a sensitive indicator of inflammation confirmed in numerous studies and has a predictive and prognostic value. NLR is a cheap, simple, fast-acting, readily available stress and inflammation parameter with high sensitivity and low specificity. Dynamic changes in the NLR precede the clinical state by several hours and may alert clinicians to the ongoing pathological process early. NLR is a new promising marker of cellular immune activation, an important indicator of stress and systemic inflammation. It opens a new dimension for clinical medicine, enabling a better understanding of the biology of inflammation, the linkage and antagonism between innate and adaptive immunity, and their clinical consequences for health and disease.

NLR is affected not only by surgical trauma but also by the method of anesthesia. In recent years, the influence of regional anesthesiology on reducing the inflammatory response after surgical procedures has been emphasized. However, there have been very few studies evaluating the effect of various methods of anesthesia on the NLR.

Conditions

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Hip Arthropathy Hip Osteoarthritis Hip Pain Chronic

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Sham blocks

PENG block with 20ml of 0.9% sodium chloride

Group Type PLACEBO_COMPARATOR

0.9% Sodium Chloride Injection

Intervention Type DRUG

After spinal anesthesia, the ultrasound-guided PENG block will be performed with 20ml of 0.9% sodium chloride

PENG block

PENG block with 20ml 0f 0.2% ropivacaine

Group Type ACTIVE_COMPARATOR

Ropivacaine 0.2% Injectable Solution

Intervention Type DRUG

After spinal anesthesia, the ultrasound-guided PENG block will be performed with 20 ml of 0.2% ropivacaine

Interventions

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0.9% Sodium Chloride Injection

After spinal anesthesia, the ultrasound-guided PENG block will be performed with 20ml of 0.9% sodium chloride

Intervention Type DRUG

Ropivacaine 0.2% Injectable Solution

After spinal anesthesia, the ultrasound-guided PENG block will be performed with 20 ml of 0.2% ropivacaine

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients with ASA classification I-III
* Aged 60-100 years
* Who will be scheduled for hip arthroplasty under spinal anesthesia

Exclusion Criteria

* Patients who have a history of bleeding diathesis
* Take anticoagulant therapy
* History of chronic pain before surgery
* Multiple trauma
* patients unable to assess their pain (dementia)
* patients operated under general anesthesia
* patients having an infection in the region of the procedure
* the patient who does not accept the procedure
Minimum Eligible Age

60 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Poznan University of Medical Sciences

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Malgorzata Reysner, M.D. Ph.D.

Role: STUDY_CHAIR

Poznan University of Medical Sciences

Locations

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Poznan University of Medical Sciences

Poznan, , Poland

Site Status

Countries

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Poland

Other Identifiers

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7/2025

Identifier Type: -

Identifier Source: org_study_id