Amino Acid PET to Assess the Efficacy of IDH Inhibitor Treatments for IDH Mutated Gliomas

NCT ID: NCT07017790

Last Updated: 2025-06-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

22 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-06-30

Study Completion Date

2025-08-30

Brief Summary

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Amino acid PET imaging could represent a biomarker for the evaluation of IDH inhibitor treatments for patients with refractory IDH-mutated gliomas

Detailed Description

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Amino acid PET imaging could represent a biomarker for the evaluation of IDH inhibitor treatments for patients with refractory IDH-mutated gliomas In fact, this study will allow us to assess, using Rano 1.0 criteria for PET and Rano 2.0 criteria for MRI, which of the two examinations is most effective in assessing the efficacy of anti-IDH treatment patients with refractory IDH-mutated gliomas.

Conditions

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Glioma

Study Design

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Observational Model Type

OTHER

Study Time Perspective

RETROSPECTIVE

Interventions

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Amino-acid PET

Patients received 18-fluoroDopa then a PET exam

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients who underwent amino acid PET for early assessment of therapeutic response of IDH-mutated gliomas under anti-IDH treatment between February 2022 and November 2024

Exclusion Criteria

* Individuals who have objected to the use of their data
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Central Hospital, Nancy, France

OTHER

Sponsor Role lead

Responsible Party

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Antoine VERGER

Principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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CHRU of NANCY

Vandœuvre-lès-Nancy, , France

Site Status

Countries

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France

Central Contacts

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Antoine VERGER, MD,PhD

Role: CONTACT

0383155567 ext. +33

Véronique ROCH, MsC

Role: CONTACT

0383154276 ext. +33

Other Identifiers

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2025PI093

Identifier Type: -

Identifier Source: org_study_id

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