Assessing the Burden of Respiratory Syncytial Virus (RSV)

NCT ID: NCT07015255

Last Updated: 2025-06-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

1500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-06-30

Study Completion Date

2026-06-30

Brief Summary

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This study examines the impact of Respiratory Syncytial Virus (RSV) on people of all ages, from infants to the elderly. It uses hospital records collected between January 2018 and December 2024 to understand:

* How often does RSV occur
* Who is most at risk
* The long-term and financial effects of RSV

Detailed Description

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This study is designed to analyze the impact of Respiratory Syncytial Virus (RSV) across different age groups. It focuses on how often RSV occurs, who is most at risk, and its long-term and financial effects. The study uses existing hospital records from SEHA facilities between January 2018 and December 2024. This is a retrospective observational study, meaning no new tests or treatments are given. Researchers look at medical records from past patients who were diagnosed with RSV. Anonymized data is collected from SEHA's Electronic Medical Records (EMR) and laboratory systems. Only patients with confirmed RSV infections are included.

Conditions

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Respiratory Syncytial Virus (RSV) Infection Acute Lower Respiratory Tract Infections Bronchiolitis Pneumonia Chronic Respiratory Conditions

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Infants, adults, elderly, and high-risk patients with confirmed RSV infection (2018-2024).

This retrospective study includes patients of all ages with confirmed Respiratory Syncytial Virus (RSV) infection from January 2018 to December 2024, categorized into four cohorts: (1) Infants and young children, including those with risk factors such as prematurity, low birth weight, and chronic lung or heart disease; (2) Adults aged 18-64 years with or without comorbidities; (3) Elderly adults aged 65 and older, with focus on severe outcomes and mortality; and (4) High-risk individuals across all age groups with underlying conditions such as asthma, COPD, diabetes, immunosuppression, Down syndrome, or cystic fibrosis. No interventions are administered; the study analyzes existing data to assess RSV burden, ICU admissions, long-term health impacts, and associated healthcare costs.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patients of all ages with a confirmed diagnosis of RSV infection
* Patients admitted to a SEHA hospital or healthcare facility between January 2018 and December 2024
* Patients with documented data in the SEHA electronic medical record (EMR) system

Exclusion Criteria

* Patients with suspected RSV infection that is not laboratory-confirmed
* Patients without sufficient data in the SEHA EMR system
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Abu Dhabi Health Services Company

OTHER_GOV

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Salah Eldin Hussein, MD

Role: STUDY_DIRECTOR

Abu Dhabi Health Services Company-SEHA

Nawal Alkaabi, MD

Role: PRINCIPAL_INVESTIGATOR

Abu Dhabi Health Services Company-SEHA

Locations

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Sheikh Khalifa Medical City (Abu Dhabi Health Research Centre), SEHA

Abu Dhabi, , United Arab Emirates

Site Status

Countries

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United Arab Emirates

Central Contacts

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Lina Khairy, MD

Role: CONTACT

+971589111897

Alina Naeem, MBBS, MS

Role: CONTACT

+971566089799

References

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Felton DA. A time of 'firsts'. J Prosthodont. 2004 Mar;13(1):1-2. doi: 10.1111/j.1532-849X.2004.04011.x. No abstract available.

Reference Type BACKGROUND
PMID: 15032890 (View on PubMed)

Zhou H, Thompson WW, Viboud CG, Ringholz CM, Cheng PY, Steiner C, Abedi GR, Anderson LJ, Brammer L, Shay DK. Hospitalizations associated with influenza and respiratory syncytial virus in the United States, 1993-2008. Clin Infect Dis. 2012 May;54(10):1427-36. doi: 10.1093/cid/cis211. Epub 2012 Apr 10.

Reference Type BACKGROUND
PMID: 22495079 (View on PubMed)

Hall CB, Weinberg GA, Iwane MK, Blumkin AK, Edwards KM, Staat MA, Auinger P, Griffin MR, Poehling KA, Erdman D, Grijalva CG, Zhu Y, Szilagyi P. The burden of respiratory syncytial virus infection in young children. N Engl J Med. 2009 Feb 5;360(6):588-98. doi: 10.1056/NEJMoa0804877.

Reference Type BACKGROUND
PMID: 19196675 (View on PubMed)

Wassmer SC, Lepolard C, Traore B, Pouvelle B, Gysin J, Grau GE. Platelets reorient Plasmodium falciparum-infected erythrocyte cytoadhesion to activated endothelial cells. J Infect Dis. 2004 Jan 15;189(2):180-9. doi: 10.1086/380761. Epub 2004 Jan 9.

Reference Type BACKGROUND
PMID: 14722881 (View on PubMed)

Callen A, Diener-West M, Zeitlin PL, Rubenstein RC. A simplified cyclic adenosine monophosphate-mediated sweat rate test for quantitative measure of cystic fibrosis transmembrane regulator (CFTR) function. J Pediatr. 2000 Dec;137(6):849-55. doi: 10.1067/mpd.2000.109198.

Reference Type BACKGROUND
PMID: 11113843 (View on PubMed)

Falsey AR, Hennessey PA, Formica MA, Cox C, Walsh EE. Respiratory syncytial virus infection in elderly and high-risk adults. N Engl J Med. 2005 Apr 28;352(17):1749-59. doi: 10.1056/NEJMoa043951.

Reference Type BACKGROUND
PMID: 15858184 (View on PubMed)

Joury J, Al Kaabi N, Al Dallal S, Mahboub B, Zayed M, Abdelaziz M, Onwumeh-Okwundu J, Fletcher MA, Kumaresan S, Ramachandrachar BC, Farghaly M. Retrospective Analysis of RSV Infection in Pediatric Patients: Epidemiology, Comorbidities, Treatment, and Costs in Dubai (2014-2023). J Health Econ Outcomes Res. 2024 Nov 5;11(2):133-144. doi: 10.36469/001c.123889. eCollection 2024.

Reference Type BACKGROUND
PMID: 39575134 (View on PubMed)

Nair H, Nokes DJ, Gessner BD, Dherani M, Madhi SA, Singleton RJ, O'Brien KL, Roca A, Wright PF, Bruce N, Chandran A, Theodoratou E, Sutanto A, Sedyaningsih ER, Ngama M, Munywoki PK, Kartasasmita C, Simoes EA, Rudan I, Weber MW, Campbell H. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet. 2010 May 1;375(9725):1545-55. doi: 10.1016/S0140-6736(10)60206-1.

Reference Type BACKGROUND
PMID: 20399493 (View on PubMed)

Related Links

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https://pubmed.ncbi.nlm.nih.gov/20399493/

Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis.

https://pubmed.ncbi.nlm.nih.gov/15858184/

Respiratory syncytial virus infection in elderly and high-risk adults.

https://pubmed.ncbi.nlm.nih.gov/11113843/

Rates of hospitalization for respiratory syncytial virus infection among children in Medicaid.

https://pubmed.ncbi.nlm.nih.gov/14722881/

Risk factors for severe respiratory syncytial virus infection in elderly persons.

https://pubmed.ncbi.nlm.nih.gov/19196675/

The burden of respiratory syncytial virus infection in young children.

https://pubmed.ncbi.nlm.nih.gov/22495079/

Hospitalizations associated with influenza and respiratory syncytial virus in the United States, 1993-2008.

https://pubmed.ncbi.nlm.nih.gov/15032890/

Economic impact of respiratory syncytial virus-related illness in the US: an analysis of national databases.

Other Identifiers

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DOH/ADHRTC/2025/361

Identifier Type: -

Identifier Source: org_study_id

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