Sarcopenia and Neuromuscular Block in Gastrointestinal Cancer Surgery
NCT ID: NCT07003061
Last Updated: 2025-06-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
100 participants
OBSERVATIONAL
2025-06-01
2025-09-20
Brief Summary
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Detailed Description
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Adult patients (aged 18 and above) scheduled for elective GI cancer surgery who have undergone preoperative abdominal computed tomography (CT) will be included. Patients with neuromuscular diseases, those on chronic steroid or immunosuppressive therapy, or those with significant organ failure will be excluded. Preoperative CT images at the L3 vertebral level will be evaluated by a radiologist to determine sarcopenia status, and patients will be divided into sarcopenic and non-sarcopenic groups according to established cut-off values.
All patients will receive standard anesthesia monitoring, including TOF (Train-of-Four) neuromuscular monitoring. The study will not alter any treatment protocols. After administration of muscle relaxants during anesthesia induction, neuromuscular block parameters such as onset time, depth, duration, need for reversal agents, and recovery time will be recorded. Demographic data, comorbidities, laboratory findings, type of surgery, and details of muscle relaxant use will also be collected.
The primary objective is to compare intraoperative neuromuscular block parameters between sarcopenic and non-sarcopenic patients. Statistical analysis will be performed using appropriate parametric or non-parametric tests for continuous variables and chi-square tests for categorical variables. The study aims to provide evidence for individualized dosing of muscle relaxants and to improve patient safety in anesthesia practice for GI cancer surgery.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Sarcopenic
Patients with gastrointestinal cancer scheduled for elective surgery who are identified as sarcopenic based on preoperative abdominal CT scans at the L3 vertebral level, according to established cut-off values.
Standard Anesthesia Management
All patients will receive standard anesthesia care as per institutional protocols. No experimental intervention will be applied.
Non-Sarcopenic
Patients with gastrointestinal cancer scheduled for elective surgery who are identified as non-sarcopenic based on preoperative abdominal CT scans at the L3 vertebral level, according to established cut-off values.
Standard Anesthesia Management
All patients will receive standard anesthesia care as per institutional protocols. No experimental intervention will be applied.
Interventions
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Standard Anesthesia Management
All patients will receive standard anesthesia care as per institutional protocols. No experimental intervention will be applied.
Eligibility Criteria
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Inclusion Criteria
* Patients diagnosed with gastrointestinal system (GIS) cancer and scheduled for elective surgery
* Patients who have undergone preoperative abdominal computed tomography (CT) imaging
* Patients classified as American Society of Anesthesiologists (ASA) physical status I-III
Exclusion Criteria
* Patients receiving chronic steroid or immunosuppressive therapy
* Patients with electrolyte imbalance
* Patients using medications that affect neuromuscular transmission
* Patients with severe organ failure in the preoperative period (e.g., liver or renal failure)
* Patients who refuse to participate in the study
* Patients requiring emergency surgery
* Patients using muscle relaxants in the preoperative period
18 Years
75 Years
ALL
Yes
Sponsors
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Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
OTHER
Responsible Party
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Mustafa Kemal ŞAHİN
Principal Investigator
Principal Investigators
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Mustafa Kemal SAHIN
Role: PRINCIPAL_INVESTIGATOR
Ankara Oncology Education and Research Hospital Clinic of Anesthesiology and Reanimation
Mensure KAYA
Role: PRINCIPAL_INVESTIGATOR
Ankara Oncology Education and Research Hospital Clinic of Anesthesiology and Reanimation
Belkis YILMAZ
Role: PRINCIPAL_INVESTIGATOR
Ankara Oncology Education and Research Hospital Clinic of Anesthesiology and Reanimation
Ahmet BAYRAK
Role: PRINCIPAL_INVESTIGATOR
Ankara Oncology Education and Research Hospital Clinic of Radiology
Locations
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Dr. Abdurrahman Yurtaslan Ankara Oncology Education and Research Hospital Clinic of Anesthesiology and Rea
Ankara, Yenimahalle, Turkey (Türkiye)
Countries
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Central Contacts
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Facility Contacts
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References
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Almeida PS, Barao K, Forones NM. SARCOPENIA AND GASTROINTESTINAL CANCER: NUTRITIONAL APPROACH FOCUSING ON CURCUMIN SUPPLEMENTATION. Arq Gastroenterol. 2025 Apr 4;62:e24068. doi: 10.1590/S0004-2803.24612024-068. eCollection 2025.
Clark BC. Neuromuscular Changes with Aging and Sarcopenia. J Frailty Aging. 2019;8(1):7-9. doi: 10.14283/jfa.2018.35.
Other Identifiers
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2025-05/79
Identifier Type: -
Identifier Source: org_study_id
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