Using Social Influencers for Public Health Education on Antibiotic Use and Antimicrobial Resistance

NCT ID: NCT06998576

Last Updated: 2025-07-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

3300 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-07-21

Study Completion Date

2027-06-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study aims to compare the effectiveness of health education facilitated by neighborhood food and beauty establishments with that facilitated by clinics in increasing the public's knowledge of antibiotic use and antimicrobial resistance (AMR) and improving antibiotic behaviors.

The quasi-experimental study will involve a total of 3300 patrons of the 10 most popular consenting clinics, food and beauty establishments respectively, in two neighborhoods in Singapore.

Recruitment Process

1. Participants will scan the QR code on the posters in the participating clinics/establishments
2. Read the study information sheet
3. Consent will be implied on submission of survey
4. Total recruitment period: One year
5. Target: 3300 patrons of the 30 establishments (10 each of clinics, food, and beauty establishments)

Intervention Structure

1. Participants will complete a pre-intervention/baseline survey (#1)
2. Intervention includes an animated educational video with key messages on appropriate antibiotic use and AMR
3. Followed by immediate post-intervention survey (#2)
4. Provide contact details (mobile phone number) for reimbursement \& future follow-up online surveys
5. Complete follow-up online surveys: at 1 month post-intervention (#3), 3 months post-intervention (#4) and 6 months post-intervention (#5)

Expected Outcomes Increase in public knowledge of antibiotic use and AMR, and antibiotic behaviors through health education facilitated by neighborhood food and beauty establishments, in addition to that facilitated by clinics

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

According to the World Health Organisation (WHO), antimicrobial resistance (AMR) is one of top 10 global public health threats facing humanity \[1,2\] and is primarily driven by overuse and misuse of antibiotics \[3\]. Majority of the population-based national AMR educational campaigns focused on raising public awareness of appropriate antibiotic use and promoting action against antimicrobial resistance have shown mixed results largely due to its "one-size-fits-all" approach \[4,5,6\].

While healthcare providers are key players in health communication and considered most trusted sources of health information across all age groups \[7\], there is a need to identify and harness non-healthcare related establishments which can serve as trusted sources of health information especially for younger age groups who are less likely to have healthcare encounters \[8-10\]. The present study aims to engage non-healthcare establishments (food and beauty) with high degree centrality in the community identified through social network analysis, and evaluate the effectiveness of sharing health information about antibiotic use facilitated by non-healthcare establishments (food and beauty) as compared to traditional healthcare sources (clinics).

The Investigators conducted an exploratory sequential mixed methods study to identify both healthcare and non-healthcare (food and beauty) establishments which were highly frequented by the residents in the community. Findings from the above study were used to select the top 10 highly frequented healthcare and non-healthcare (food and beauty) establishments.

A quasi-experimental study will be conducted to compare the effectiveness of sharing health information about antibiotic use and AMR facilitated through healthcare clinics, and beauty and food establishments in 2 neighborhoods. Participants (patients/patrons) who visit the participating establishments (clinics/food establishments/beauty establishments) will be invited to take part in the study by scanning the QR code on the recruitment posters placed inside the premises. Upon scanning the QR code, participants will proceed to complete a pre-intervention questionnaire survey (#1) on an online platform after going through the study information sheet. Upon completion of the survey #1, participants will be guided through embedded instructions to click on a link to access the health educational intervention. The educational intervention includes a short 2-minute animated video (developed based on the preferences of the community as identified from the results of the quantitative survey) will be hosted on a multimedia online platform providing key information on appropriate antibiotic use and AMR. After viewing the video, the participants will be subsequently led to the post-intervention survey #2 via a link. Before submitting survey #2, contact details (mobile number) and the preferred payment method will be collected for reimbursement purposes and future follow-up surveys. The enrolled participants will be re-contacted by the study team via a mobile messaging service (such as WhatsApp), and will be guided through embedded instructions to complete three more surveys (#3, #4 \& #5) at 1-, 3-, and 6-month post-intervention to assess knowledge on antibiotic use and AMR and behaviors on antibiotic use. Participants will be recruited from all 30 participating establishments (10 clinics, 10 F\&B shops, 10 beauty salons) for the entire study duration of one year and will be followed up for 6 months after the intervention.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Community Members

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

A quasi-experimental study will be conducted to compare the effectiveness of public health education via an animated educational video on antibiotic use and AMR that is facilitated by neighborhood food and beauty establishments (social influencers) with that facilitated through clinics (traditional source of information).
Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Healthcare clinics

Ten healthcare clinics will be chosen. Patients will enrol into the study by scanning the QR code on the recruitment poster at the participating healthcare clinics will access the health educational intervention.

Group Type EXPERIMENTAL

Animated educational video on antibiotic use

Intervention Type BEHAVIORAL

The intervention features a concise animated video on antibiotic use and AMR. The video's content and format will be developed based on the results of a survey conducted among the community residents in the two neighborhoods. Through the survey, the participants evaluated multiple message options including the various delivery formats. The animated video was designed incorporating the community's preferred key message and delivery method. The resulting video uses graphics, voice-overs, captions \[in all 4 official national languages\] to convey key messages about appropriate antibiotic use and AMR.

Food establishments

Ten food establishments will be chosen. Patrons will enrol in the study by scanning the QR code on the recruitment poster at the participating F\&B shops will access the health educational intervention.

Group Type EXPERIMENTAL

Animated educational video on antibiotic use

Intervention Type BEHAVIORAL

The intervention features a concise animated video on antibiotic use and AMR. The video's content and format will be developed based on the results of a survey conducted among the community residents in the two neighborhoods. Through the survey, the participants evaluated multiple message options including the various delivery formats. The animated video was designed incorporating the community's preferred key message and delivery method. The resulting video uses graphics, voice-overs, captions \[in all 4 official national languages\] to convey key messages about appropriate antibiotic use and AMR.

Beauty establishments

Ten beauty etablishments will be chosen. Patrons will enrol in the study by scanning the QR code on the recruitment poster at the participating beauty establishments will access the health educational intervention.

Group Type EXPERIMENTAL

Animated educational video on antibiotic use

Intervention Type BEHAVIORAL

The intervention features a concise animated video on antibiotic use and AMR. The video's content and format will be developed based on the results of a survey conducted among the community residents in the two neighborhoods. Through the survey, the participants evaluated multiple message options including the various delivery formats. The animated video was designed incorporating the community's preferred key message and delivery method. The resulting video uses graphics, voice-overs, captions \[in all 4 official national languages\] to convey key messages about appropriate antibiotic use and AMR.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Animated educational video on antibiotic use

The intervention features a concise animated video on antibiotic use and AMR. The video's content and format will be developed based on the results of a survey conducted among the community residents in the two neighborhoods. Through the survey, the participants evaluated multiple message options including the various delivery formats. The animated video was designed incorporating the community's preferred key message and delivery method. The resulting video uses graphics, voice-overs, captions \[in all 4 official national languages\] to convey key messages about appropriate antibiotic use and AMR.

Intervention Type BEHAVIORAL

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Adults aged 21 years and above
* Patrons of the 30 participating healthcare clinics, food and beauty establishments

Exclusion Criteria

* Patrons who are already enrolled in the study at one of the 30 participating establishments
Minimum Eligible Age

21 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Tan Tock Seng Hospital

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Chow Li Ping Angela

Senior Consultant, Department of Epidemiology and Preventive Medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Tan Tock Seng Hospital

Singapore, Singapore, Singapore

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

Singapore

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Angela Chow, MBBS, MMed(PH), PhD

Role: CONTACT

+65-62566011

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Chow Angela, MBBS, MMed(PH), PhD

Role: primary

+65-62566011

Seema K Aithal, MBBS, MPH

Role: backup

+65-62566011

References

Explore related publications, articles, or registry entries linked to this study.

Chow A, Aithal S, Guo H, Lwin MO, Hildon ZJ. Using social influencers for public health education on antibiotic use and antimicrobial resistance: protocol for a quasi-experimental study. BMC Public Health. 2025 Sep 24;25(1):3120. doi: 10.1186/s12889-025-24338-z.

Reference Type DERIVED
PMID: 40993665 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

CSAINV22jul-0010

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Communities Fighting COVID-19!
NCT05148936 COMPLETED NA