Outcomes of PRF on Septoplasty in Patient With Nasal Septal Deviation

NCT ID: NCT06996106

Last Updated: 2025-05-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-06-30

Study Completion Date

2026-02-01

Brief Summary

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The aim of this study is to assess the effectiveness of Platelet-Rich Fibrin (PRF) in improving postoperative healing, reducing complications, and enhancing functional outcomes in patients undergoing septoplasty

Detailed Description

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Septoplasty is a routine surgical intervention to correct nasal septal deviation, a major cause of nasal obstruction and chronic sinusitis. Despite advancements, postoperative complications-such as mucosal injury, synechiae, septal perforation, and hematoma-continue to impact outcomes and patient satisfaction.

Platelet-rich fibrin (PRF), first described by Choukroun et al., represents an autologous biomaterial rich in growth factors like PDGF, TGF-β, VEGF, and IGF-1, known to accelerate wound healing and tissue regeneration. Unlike platelet-rich plasma (PRP), PRF is easier to prepare, does not require anticoagulants, and forms a fibrin matrix conducive to sustained release of cytokines.

Several studies across disciplines-oral surgery, dermatology, orthopedics-support the regenerative potential of PRF. In nasal surgery, the delicate mucosal environment could benefit significantly from enhanced healing facilitated by PRF.

Conditions

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Nasal Septum; Deviation Nasal Septal Srur

Study Design

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Allocation Method

NA

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Participants

Study Groups

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platelet rich fibrin

usage of platelet rich fibrin in this arm underging setoplasty

Group Type ACTIVE_COMPARATOR

Effect of Platelet Rich Fibrin on Septoplasty

Intervention Type OTHER

it is a randomized trial of usage of platelet rich fibrin in septoplasty

control group

traditional septoplasty

Group Type ACTIVE_COMPARATOR

Effect of Platelet Rich Fibrin on Septoplasty

Intervention Type OTHER

it is a randomized trial of usage of platelet rich fibrin in septoplasty

Interventions

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Effect of Platelet Rich Fibrin on Septoplasty

it is a randomized trial of usage of platelet rich fibrin in septoplasty

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Adults aged 18-65 years undergoing septoplasty. Presence of cartilage deviated nasal septum requiring repair. No contraindications to PRF therapy.

Exclusion Criteria

* History of coagulopathy or anticoagulant therapy. Active infection or systemic disease. Known hypersensitivity to PRF components. Previous nasal surgery Autoimmune or systemic inflammatory disease
Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Kafrelsheikh University

OTHER

Sponsor Role lead

Responsible Party

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Ahmed Ibrahim Abdallah Abdel wahd Abo Hussein

ahmed ibrahim

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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‪Ahmed ibrahim‬, M.B.B. Ch, Otorhinolary

Role: CONTACT

0201014848903

Other Identifiers

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PRF in septoplasty

Identifier Type: -

Identifier Source: org_study_id

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