A Long Term Follow-up Study of TScan TCR-T Products

NCT ID: NCT06976736

Last Updated: 2025-09-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-09-09

Study Completion Date

2040-09-30

Brief Summary

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The purpose of this Long-Term Follow-Up (LTFU) study is to monitor participants who have previously received TSC-100 or TSC-101 TCR-T therapies in the TSCAN-001 study. Participants will be monitored for 15 years from the date of TCR-T cell therapy administration to assess long-term safety and efficacy.

Detailed Description

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Participants will enroll in this LTFU study after completing the TSCAN-001 interventional trial. No additional study drug will be administered; however, participants may receive other cancer treatments as needed while being monitored for long-term safety.

Enrollment will occur after completion of the TSCAN-001 study, and participants will be monitored for safety and efficacy over a 15 year period.

Conditions

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AML ALL MDS

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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Observational

No study drug will be administered during this trial. Participants previously treated with TSC-100 or TSC-101 in a TScan study will be evaluated for long-term safety and efficacy.

Observational

Intervention Type OTHER

Long Term Follow-Up for participants treated with TSC-100 or TSC-101 TCR-T products

Interventions

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Observational

Long Term Follow-Up for participants treated with TSC-100 or TSC-101 TCR-T products

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Participants who received a TCR-T cellular therapy in a clinical study sponsored by TScan Therapeutics.
* Signed informed consent.

Exclusion Criteria

* None
Minimum Eligible Age

18 Years

Maximum Eligible Age

110 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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TScan Therapeutics, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Michelle Matzko, MD

Role: STUDY_DIRECTOR

Medical Monitor

Locations

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City of Hope

Duarte, California, United States

Site Status RECRUITING

Mount Sinai

New York, New York, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Madhavi Desai

Role: CONTACT

(857) 399-9832

Facility Contacts

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Monzr M Al Malki, MD

Role: primary

Alla Keyzner, MD

Role: primary

Other Identifiers

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TSCAN-004

Identifier Type: -

Identifier Source: org_study_id

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