Spatiotemporal Thalamocortical Alterations Underlie Experimental and Chronic Pain
NCT ID: NCT06968689
Last Updated: 2026-01-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
60 participants
INTERVENTIONAL
2025-05-12
2027-11-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
TRIPLE
Study Groups
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tACS then tRNS then sham
transcranial alternating current stimulation (tACS)
Participants will get a personalized brain stimulation: a 2 milliampere (mA) oscillating current that matches their natural alpha brain wave frequency (8-12 Hz), determined by a quick 3-minute EEG before the session.
Sham
Active sham stimulation with 60- second -tACS will be applied , then ramp down, and be reintroduced in the last 30 seconds to minimize awareness of the experimental condition
transcranial random noise stimulation (tRNS)
Participants will still get stimulation, but at random frequencies between 1 and 200 Hz (instead of targeted alpha waves).
tACS then sham then tRNS
transcranial alternating current stimulation (tACS)
Participants will get a personalized brain stimulation: a 2 milliampere (mA) oscillating current that matches their natural alpha brain wave frequency (8-12 Hz), determined by a quick 3-minute EEG before the session.
Sham
Active sham stimulation with 60- second -tACS will be applied , then ramp down, and be reintroduced in the last 30 seconds to minimize awareness of the experimental condition
transcranial random noise stimulation (tRNS)
Participants will still get stimulation, but at random frequencies between 1 and 200 Hz (instead of targeted alpha waves).
tRNS then tACS then sham
transcranial alternating current stimulation (tACS)
Participants will get a personalized brain stimulation: a 2 milliampere (mA) oscillating current that matches their natural alpha brain wave frequency (8-12 Hz), determined by a quick 3-minute EEG before the session.
Sham
Active sham stimulation with 60- second -tACS will be applied , then ramp down, and be reintroduced in the last 30 seconds to minimize awareness of the experimental condition
transcranial random noise stimulation (tRNS)
Participants will still get stimulation, but at random frequencies between 1 and 200 Hz (instead of targeted alpha waves).
tRNS then sham then tACS
transcranial alternating current stimulation (tACS)
Participants will get a personalized brain stimulation: a 2 milliampere (mA) oscillating current that matches their natural alpha brain wave frequency (8-12 Hz), determined by a quick 3-minute EEG before the session.
Sham
Active sham stimulation with 60- second -tACS will be applied , then ramp down, and be reintroduced in the last 30 seconds to minimize awareness of the experimental condition
transcranial random noise stimulation (tRNS)
Participants will still get stimulation, but at random frequencies between 1 and 200 Hz (instead of targeted alpha waves).
Sham then tRNS then tACS
transcranial alternating current stimulation (tACS)
Participants will get a personalized brain stimulation: a 2 milliampere (mA) oscillating current that matches their natural alpha brain wave frequency (8-12 Hz), determined by a quick 3-minute EEG before the session.
Sham
Active sham stimulation with 60- second -tACS will be applied , then ramp down, and be reintroduced in the last 30 seconds to minimize awareness of the experimental condition
transcranial random noise stimulation (tRNS)
Participants will still get stimulation, but at random frequencies between 1 and 200 Hz (instead of targeted alpha waves).
Sham then tACS then tRNS
transcranial alternating current stimulation (tACS)
Participants will get a personalized brain stimulation: a 2 milliampere (mA) oscillating current that matches their natural alpha brain wave frequency (8-12 Hz), determined by a quick 3-minute EEG before the session.
Sham
Active sham stimulation with 60- second -tACS will be applied , then ramp down, and be reintroduced in the last 30 seconds to minimize awareness of the experimental condition
transcranial random noise stimulation (tRNS)
Participants will still get stimulation, but at random frequencies between 1 and 200 Hz (instead of targeted alpha waves).
Interventions
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transcranial alternating current stimulation (tACS)
Participants will get a personalized brain stimulation: a 2 milliampere (mA) oscillating current that matches their natural alpha brain wave frequency (8-12 Hz), determined by a quick 3-minute EEG before the session.
Sham
Active sham stimulation with 60- second -tACS will be applied , then ramp down, and be reintroduced in the last 30 seconds to minimize awareness of the experimental condition
transcranial random noise stimulation (tRNS)
Participants will still get stimulation, but at random frequencies between 1 and 200 Hz (instead of targeted alpha waves).
Eligibility Criteria
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Inclusion Criteria
* Fluent in English
Exclusion Criteria
* History of cardiac, respiratory, or nervous system disease that, in the investigator's judgment, precludes participation in the study because of a heightened potential for adverse outcome (for example: asthma or claustrophobia)
* History of head trauma
* Pregnant or lactating
* Presence of any contraindications to MRI scanning (for example: cardiac pacemaker, metal implants, claustrophobia, pregnancy, cannot lie still in fMRI scanner)
* Conditions making study participation difficult (e.g., paralysis, psychoses, or other severe psychological problems as per the judgment of a study investigator during Session 1)
* Active substance abuse disorders (based on subject self-report)
18 Years
60 Years
ALL
Yes
Sponsors
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National Institute of Neurological Disorders and Stroke (NINDS)
NIH
The University of Texas Health Science Center, Houston
OTHER
Responsible Party
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Wen Li
Professor
Principal Investigators
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Wen Li, PhD
Role: PRINCIPAL_INVESTIGATOR
The University of Texas Health Science Center, Houston
Locations
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The University of Texas Health Science Center at Houston
Houston, Texas, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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HSC-MS-25-0062
Identifier Type: -
Identifier Source: org_study_id
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